日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

5,10b-乙并菲啶类石蒜科生物碱启发了新型双环体系的发现,这些体系对耐药癌细胞具有活性。

Henry, Sean; Kidner, Ria; Reisenauer, Mary R; Magedov, Igor V; Kiss, Robert; Mathieu, Véronique; Lefranc, Florence; Dasari, Ramesh; Evidente, Antonio; Yu, Xiaojie; Ma, Xiuye; Pertsemlidis, Alexander; Cencic, Regina; Pelletier, Jerry; Cavazos, David A; Brenner, Andrew J; Aksenov, Alexander V; Rogelj, Snezna; Kornienko, Alexander; Frolova, Liliya V

Isatin derivatives with activity against apoptosis-resistant cancer cells

具有抗凋亡癌细胞活性的靛红衍生物

Evdokimov, Nikolai M; Magedov, Igor V; McBrayer, Dominic; Kornienko, Alexander

Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells

2-芳基-2-(3-吲哚基)乙酰羟肟酸酯对抗耐药癌细胞的活性

Alexander V Aksenov, Alexander N Smirnov, Igor V Magedov, Mary R Reisenauer, Nicolai A Aksenov, Inna V Aksenova, Alexander L Pendleton, Gina Nguyen, Robert K Johnston, Michael Rubin, Annelise De Carvalho, Robert Kiss, Véronique Mathieu, Florence Lefranc, Jaime Correa, David A Cavazos, Andrew J Brenn

Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification

亲脂性前药结合物可以轻松快速地合成高负载容量的脂质体,而无需进行组装后纯化

Alexander A Mikhalin, Nikolai M Evdokimov, Liliya V Frolova, Igor V Magedov, Alexander Kornienko, Robert Johnston, Snezna Rogelj, Michaelann S Tartis

Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins

对源自海洋生物碱刚毛素的 C2 位取代的 7-脱氮次黄嘌呤类化合物进行合成和生物学研究,这些化合物靶向微管蛋白。

Scott, Robert; Karki, Menuka; Reisenauer, Mary R; Rodrigues, Roberta; Dasari, Ramesh; Smith, W Ross; Pelly, Stephen C; van Otterlo, Willem A L; Shuster, Charles B; Rogelj, Snezna; Magedov, Igor V; Frolova, Liliya V; Kornienko, Alexander

Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids

利用多组分反应探索天然产物化学和生物学。5. 发现一种源自海洋生物碱刚毛素家族的新型微管蛋白靶向支架。

Frolova, Liliya V; Magedov, Igor V; Romero, Anntherese E; Karki, Menuka; Otero, Isaiah; Hayden, Kathryn; Evdokimov, Nikolai M; Banuls, Laetitia Moreno Y; Rastogi, Shiva K; Smith, W Ross; Lu, Shi-Long; Kiss, Robert; Shuster, Charles B; Hamel, Ernest; Betancourt, Tania; Rogelj, Snezna; Kornienko, Alexander

Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells

2,3-二取代吲哚对抗凋亡癌细胞的抗增殖活性

Magedov, Igor V; Lefranc, Florence; Frolova, Liliya V; Banuls, Laetitia Moreno Y; Peretti, Amanda S; Rogelj, Snezna; Mathieu, Véronique; Kiss, Robert; Kornienko, Alexander

Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells

球茎精胺:一种石蒜科植物的克林宁型生物碱,对具有抗凋亡能力的神经胶质瘤细胞具有细胞抑制活性。

Luchetti, Giovanni; Johnston, Robert; Mathieu, Véronique; Lefranc, Florence; Hayden, Kathryn; Andolfi, Anna; Lamoral-Theys, Delphine; Reisenauer, Mary R; Champion, Cody; Pelly, Stephen C; van Otterlo, Willem A L; Magedov, Igor V; Kiss, Robert; Evidente, Antonio; Rogelj, Snezna; Kornienko, Alexander

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity

利用多组分合成法简化生物活性天然产物的结构。4. 具有抗癌活性的4H-吡喃并[2,3-b]萘醌类化合物

Magedov, Igor V; Kireev, Artem S; Jenkins, Aaron R; Evdokimov, Nikolai M; Lima, Dustin T; Tongwa, Paul; Altig, Jeff; Steelant, Wim F A; Van slambrouck, Severine; Antipin, Mikhail Yu; Kornienko, Alexander

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

利用多组分合成法简化生物活性天然产物的结构。3. 稠合含尿嘧啶杂环化合物作为新型拓扑异构酶靶向剂

Evdokimov, Nikolai M; Van Slambrouck, Severine; Heffeter, Petra; Tu, Lee; Le Calvé, Benjamin; Lamoral-Theys, Delphine; Hooten, Carla J; Uglinskii, Pavel Y; Rogelj, Snezna; Kiss, Robert; Steelant, Wim F A; Berger, Walter; Yang, Jeremy J; Bologa, Cristian G; Kornienko, Alexander; Magedov, Igor V