Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells
类 PI3K-alpha 和 delta 亚型的联合抑制可诱导衰老细胞中 p21WAF1/CIP1 蛋白酶体降解,从而导致衰老细胞溶解
期刊:Cell Death & Disease
影响因子:8.1
doi:10.1038/s41419-024-06755-x
Judith Neuwahl, Chantal A Neumann, Annika C Fitz, Anica D Biermann, Maja Magel, Annabelle Friedrich, Lorenz Sellin, Björn Stork, Roland P Piekorz, Peter Proksch, Wilfried Budach, Reiner U Jänicke, Dennis Sohn
信号转导
细胞生物学
其它细胞
ELISA
IF
IHC-P
IP
WB
PI3K/Akt
Senescence
Human