日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.

N-嘧啶基-β-硫代苯基丙烯酰胺对 tRNA 合成酶 Gln4 的变构抑制作用具有高度选择性的抗真菌活性

Puumala Emily, Sychantha David, Lach Elizabeth, Reeves Shawn, Nabeela Sunna, Fogal Meea, Nigam AkshatKumar, Johnson Jarrod W, Aspuru-Guzik Alán, Shapiro Rebecca S, Uppuluri Priya, Kalyaanamoorthy Subha, Magolan Jakob, Whitesell Luke, Robbins Nicole, Wright Gerard D, Cowen Leah E

A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli

细胞包膜应激筛选发现大肠杆菌中一种前脂蛋白二酰甘油转移酶抑制剂 Lgt

Kenneth Rachwalski ,Sean J Madden ,Nicole Ritchie ,Shawn French ,Timsy Bhando ,Adele Girgis-Gabardo ,Megan Tu ,Rodion Gordzevich ,Rowan Ives ,Amelia B Y Guo ,Jarrod W Johnson ,Yiming Xu ,Sharookh B Kapadia ,Jakob Magolan ,Eric D Brown

High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics

利用高通量方法发现合成铁载体作为特洛伊木马抗生素

Weber, Brent S; Ritchie, Nikki E; Hilker, Simon; Chan, Derek C K; Peukert, Carsten; Deisinger, Julia P; Ives, Rowan; Årdal, Christine; Burrows, Lori L; Brönstrup, Mark; Magolan, Jakob; Raivio, Tracy L; Brown, Eric D

Garcinia buchananii stem bark extract and its bioactive constituents manniflavanone, GB-2 and buchananiflavanone attenuate intestinal inhibitory neuromuscular transmission

藤黄树树皮提取物及其生物活性成分甘露醇黄酮、GB-2 和藤黄黄酮可减弱肠道抑制性神经肌肉传递

Savannah Patterson, Michael Elder Waters, Nancy Braman, Roan Willson, Rodney A Hill, Jakob Magolan, Thomas Hofmann, Timo D Stark, Onesmo B Balemba

Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

咖啡因阻断 SREBP2 诱导的肝脏 PCSK9 表达,从而增强 LDLR 介导的胆固醇清除

Paul F Lebeau #, Jae Hyun Byun #, Khrystyna Platko, Paul Saliba, Matthew Sguazzin, Melissa E MacDonald, Guillaume Paré, Gregory R Steinberg, Luke J Janssen, Suleiman A Igdoura, Mark A Tarnopolsky, S R Wayne Chen, Nabil G Seidah, Jakob Magolan, Richard C Austin

QSAR models reveal new EPAC-selective allosteric modulators

QSAR模型揭示了新型EPAC选择性变构调节剂

Mohamed, Hebatallah; Shao, Hongzhao; Akimoto, Madoka; Darveau, Patrick; MacKinnon, Marc R; Magolan, Jakob; Melacini, Giuseppe

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

基于巨噬细胞的筛选可识别针对细胞内鼠伤寒沙门氏菌的选择性抗菌化合物

Michael J Ellis, Caressa N Tsai, Jarrod W Johnson, Shawn French, Wael Elhenawy, Steffen Porwollik, Helene Andrews-Polymenis, Michael McClelland, Jakob Magolan, Brian K Coombes, Eric D Brown