日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II

通过使用 N-取代哌啶基二苯磺酰基磺酰胺抑制分泌型卷曲相关蛋白 I (sFRP-1) 来调节 Wnt 信号传导:第二部分

William J Moore, Jeffrey C Kern, Ramesh Bhat, Peter V N Bodine, Shoichi Fukyama, Girija Krishnamurthy, Ronald L Magolda, Keith Pitts, Barb Stauffer, Eugene J Trybulski

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate

(1-(4-(萘-2-基)嘧啶-2-基)哌啶-4-基)甲胺:一种无翼β-连环蛋白激动剂,可提高骨形成率

Jeffrey C Pelletier, Joseph T Lundquist 4th, Adam M Gilbert, Nipa Alon, Frederick J Bex, Bheem M Bhat, Mattew G Bursavich, Valerie E Coleburn, Luciana A Felix, Daniel M Green, Paula Green, Diane B Hauze, Yogendra P Kharode, Ho-Sun Lam, Susan R Lockhead, Ronald L Magolda, Jeanne J Matteo, John F Mehl

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

雷帕霉素类似物与钙通道和 FKBP52 的结合有助于其发挥神经保护作用

Benfang Ruan, Kevin Pong, Flora Jow, Mark Bowlby, Robert A Crozier, Danni Liu, Shi Liang, Yi Chen, Mary Lynn Mercado, Xidong Feng, Frann Bennett, David von Schack, Leonard McDonald, Margaret M Zaleska, Andrew Wood, Peter H Reinhart, Ronald L Magolda, Jerauld Skotnicki, Menelas N Pangalos, Frank E Ko

Isothiazolones interfere with normal matrix metalloproteinase activation and inhibit cartilage proteoglycan degradation

异噻唑啉类药物会干扰正常的基质金属蛋白酶活化,并抑制软骨蛋白聚糖的降解。

Arner, E C; Pratta, M A; Freimark, B; Lischwe, M; Trzaskos, J M; Magolda, R L; Wright, S W

Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2

碳环血栓素A2(血栓素A2的稳定类似物)可分离血栓素的血管收缩活性和血小板聚集活性

Lefer, A M; Smith, E F 3rd; Araki, H; Smith, J B; Aharony, D; Claremon, D A; Magolda, R L; Nicolaou, K C

Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation

蒎烷-血栓素A2的合成及其生物学特性,该化合物是冠状动脉收缩、血小板聚集和血栓素形成的选择性抑制剂

Nicolaou, K C; Magolda, R L; Smith, J B; Aharony, D; Smith, E F; Lefer, A M