Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition
奈非那韦通过诱导未折叠蛋白反应、调节蛋白质合成、DNA损伤、溶酶体功能障碍以及增强蛋白酶体抑制引起的毒性,对高级别浆液性卵巢癌细胞产生细胞毒性。
期刊:Cancers
影响因子:4.4
doi:10.3390/cancers14010099
Subeha, Mahbuba R; Goyeneche, Alicia A; Bustamante, Prisca; Lisio, Michael A; Burnier, Julia V; Telleria, Carlos M