日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of new thiadiazole-based VEGFR-2 inhibitors: design, synthesis, cytotoxicity, and apoptosis induction

新型噻二唑类VEGFR-2抑制剂的发现：设计、合成、细胞毒性和凋亡诱导

期刊:Future Medicinal Chemistry
影响因子:3.4
doi:10.1080/17568919.2025.2552639
Elkaeed, Eslam B; Elgammal, Walid E; Elkady, Hazem; Mahdy, Hazem A; Alsfouk, Aisha A; Husein, Dalal Z; Soliman, Omar A; Omara, Mariam; Eissa, Ibrahim H; Metwaly, Ahmed M
EGFR
毒理研究
凋亡
细胞生物学
表观遗传
VEGF
EGF
发表日期：2025
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Design and synthesis of thiadiazoles as anticancer, apoptotic, and VEGFR-2 inhibitors

噻二唑类化合物的设计与合成及其作为抗癌、凋亡和VEGFR-2抑制剂的应用

期刊:Future Medicinal Chemistry
影响因子:3.4
doi:10.1080/17568919.2025.2485863
Elgammal, Walid E; Elkady, Hazem; Dahab, Mohammed A; Mahdy, Hazem A; Hagras, Mohamed; Nofal, Ahmed; Alsfouk, Bshra A; Elkaeed, Eslam B; Eissa, Ibrahim H; Metwaly, Ahmed M
肿瘤
凋亡
表观遗传
肿瘤免疫
EGF
EGFR
VEGF
发表日期：2025
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A novel sulfamoylphenyl-dihydro-thiadiazole derivative as a dual EGFR and carbonic anhydrase inhibitor for cancer therapy

一种新型磺酰苯基二氢噻二唑衍生物作为双重EGFR和碳酸酐酶抑制剂用于癌症治疗

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0328305
Eissa, Ibrahim H; Elkady, Hazem; Elgammal, Walid E; Mahdy, Hazem A; Husein, Dalal Z; Amin, Fatma G; Elsheshiny, Asmaa A A; Abdelfattah, Shimaa S; Alsfouk, Aisha A; Elkaeed, Eslam B; Metwaly, Ahmed M
EGF
EGFR
肿瘤
肿瘤免疫
发表日期：2025
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Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs.

设计、合成和生物学评价新型潜在的非常规修饰抗癌免疫调节剂，作为可能的非致畸性喹唑啉类沙利度胺类似物

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms241512416
Mabrouk Reda R, Abdallah Abdallah E, Mahdy Hazem A, El-Kalyoubi Samar A, Kamal Omar Jamal, Abdelghany Tamer M, Zayed Mohamed F, Alshaeri Heba K, Alasmari Moudi M, El-Zahabi Mohamed Ayman
肿瘤
肿瘤免疫
发表日期：2023
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Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers.

设计、合成、计算机模拟研究和生物学评价新型嘧啶-5-腈衍生物作为潜在的抗增殖剂、VEGFR-2抑制剂和凋亡诱导剂

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d3ra04182d
Saleh Abdulrahman M, Mahdy Hazem A, El-Zahabi Mohamed Ayman, Mehany Ahmed B M, Khalifa Mohamed M, Eissa Ibrahim H
表观遗传
EGFR
凋亡
发表日期：2023
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New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies

新型苯并恶唑衍生物作为潜在的VEGFR-2抑制剂和细胞凋亡诱导剂：设计、合成、抗增殖活性评价、流式细胞术分析和计算机模拟研究

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2021.2015343
Elkady, Hazem; Elwan, Alaa; El-Mahdy, Hesham A; Doghish, Ahmed S; Ismail, Ahmed; Taghour, Mohammed S; Elkaeed, Eslam B; Eissa, Ibrahim H; Dahab, Mohammed A; Mahdy, Hazem A; Khalifa, Mohamed M
EGFR
表观遗传
EGF
VEGF
凋亡
FCM
细胞生物学
发表日期：2022
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Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation

苯并恶唑衍生物作为新型VEGFR-2抑制剂和细胞凋亡诱导剂：设计、合成、计算机模拟研究及抗增殖活性评价

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2022.2103552
Taghour, Mohammed S; Mahdy, Hazem A; Gomaa, Maher H; Aglan, Ahmed; Eldeib, Mahmoud Gomaa; Elwan, Alaa; Dahab, Mohammed A; Elkaeed, Eslam B; Alsfouk, Aisha A; Khalifa, Mohamed M; Eissa, Ibrahim H; Elkady, Hazem
EGFR
表观遗传
EGF
VEGF
凋亡
细胞生物学
发表日期：2022
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New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

新型喹啉和靛红衍生物作为凋亡性VEGFR-2抑制剂：设计、合成、抗增殖活性、分子对接、ADMET性质、毒性及分子动力学模拟研究

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2022.2110869
Elkaeed, Eslam B; Taghour, Mohammed S; Mahdy, Hazem A; Eldehna, Wagdy M; El-Deeb, Nehal M; Kenawy, Ahmed M; A Alsfouk, Bshra; Dahab, Mohammed A; Metwaly, Ahmed M; Eissa, Ibrahim H; El-Zahabi, Mohamed A
EGFR
毒理研究
表观遗传
MET
EGF
VEGF
凋亡
发表日期：2022
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