日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens

利用全基因组 CRISPR-Cas9 筛选技术对人类细胞中的基因相互作用进行定量分析

Billmann, Maximilian; Costanzo, Michael; Rahman, Mahfuzur; Chan, Katherine; Yan Tong, Amy Hin; Ward, Henry N; Hassan, Arshia Z; Zhang, Xiang; Brown, Kevin R; Rohde, Thomas; Shaw, Angela H; Ross, Catherine; van Leeuwen, Jolanda; Aregger, Michael; Lawson, Keith; Mair, Barbara; Mero, Patricia; Usaj, Matej; Andrews, Brenda; Boone, Charles; Moffat, Jason; Myers, Chad L

SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRAS(G12D) inhibitor in KRAS LUAD.

SOS1 抑制剂 BI-3406 在体内显示出类似于基因消融的抗肿瘤活性,并且与 KRAS(G12D) 抑制剂在 KRAS LUAD 中具有协同作用

Baltanás Fernando C, Kramer-Drauberg Maximilian, García-Navas Rósula, Patrucco Enrico, Petrini Ettore, Arnhof Heribert, Olarte-San Juan Andrea, Rodríguez-Ramos Pablo, Borrajo Javier, Calzada Nuria, Castellano Esther, Mair Barbara, Kostyrko Kaja, Hofmann Marco H, Ambrogio Chiara, Santos Eugenio

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

人类细胞的全局基因相互作用图谱揭示了基因网络的保守原则

Billmann, Maximilian; Costanzo, Michael; Zhang, Xiang; Hassan, Arshia Z; Rahman, Mahfuzur; Brown, Kevin R; Chan, Katherine S; Tong, Amy Hin Yan; Pons, Carles; Ward, Henry N; Ross, Catherine; van Leeuwen, Jolanda; Aregger, Michael; Lawson, Keith A; Mair, Barbara; Roth, Amy F; Sen, Nesli E; Forster, Duncan; Tan, Guihong; Mero, Patricia; Masud, Sanna N; Lee, Yoonkyu; Aguilera-Uribe, Magali; Usaj, Matej; Almeida, Sylvia M T; Aulakh, Kamaldeep; Bhojoo, Urvi; Birkadze, Saba; Budijono, Nathaniel; Cai, Xunhui; Caumanns, Joseph J; Chandrashekhar, Megha; Chang, Daniel; Climie, Ryan; Dasgupta, Kuheli; Drazic, Adrian; Rojas Echenique, Jose I; Gacesa, Rafael; Granda Farias, Adrian; Habsid, Andrea; Horecka, Ira; Kantautas, Kristin; Ji, Fenghu; Kim, Dae-Kyum; Lee, Seon Yong; Liang, Wendy; Lim, Julianne; Lin, Kevin; Lu, Xueibing; Nami, Babak; Nixon, Allison; Mikolajewicz, Nicholas; Nedyalkova, Lyudmila; Rohde, Thomas; Sartori Rodrigues, Maria; Soste, Martin; Schultz, Eric; Wang, Wen; Seetharaman, Ashwin; Shuteriqi, Emira; Sizova, Olga; Thomson Taylor, David; Tereshchenko, Maria; Tieu, David; Turowec, Jacob; Ubhi, Tajinder; Varland, Sylvia; Wang, Kyle E; Wang, Zi Yang; Wei, Jiarun; Xiao, Yu-Xi; Brown, Grant W; Cravatt, Benjamin F; Dixon, Scott J; Wyatt, Haley D M; Röst, Hannes L; Roth, Frederick P; Xia, Tian; Bader, Gary D; Loewith, Robbie; Davis, Nicholas G; Andrews, Brenda; Myers, Chad L; Moffat, Jason; Boone, Charles

A Method to Map Gene Essentiality of Human Pluripotent Stem Cells by Genome-Scale CRISPR Screens with Inducible Cas9

利用诱导型Cas9进行全基因组CRISPR筛选,绘制人类多能干细胞基因必需性图谱的方法

Mair, Barbara; Aregger, Michael; Tong, Amy H Y; Chan, Katherine S K; Moffat, Jason

CRISPR screens are feasible in TP53 wild-type cells

CRISPR筛选在TP53野生型细胞中是可行的。

Brown, Kevin R; Mair, Barbara; Soste, Martin; Moffat, Jason

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

发现一种对组蛋白赖氨酸去甲基化酶 KDM2/7 具有高选择性的细胞活性抑制剂

Gerken, Philip A; Wolstenhulme, Jamie R; Tumber, Anthony; Hatch, Stephanie B; Zhang, Yijia; Müller, Susanne; Chandler, Shane A; Mair, Barbara; Li, Fengling; Nijman, Sebastian M B; Konietzny, Rebecca; Szommer, Tamas; Yapp, Clarence; Fedorov, Oleg; Benesch, Justin L P; Vedadi, Masoud; Kessler, Benedikt M; Kawamura, Akane; Brennan, Paul E; Smith, Martin D