CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1.
通过 CRISPR 筛选人类胰腺癌异种移植瘤，发现 KLF5 增殖脆弱性与表观遗传修饰因子 NCAPD2 和 MTHFD1 有关。
期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-026-02575-z
Maeda Masahiro, Sherman Kenna, Zhou Weiqiang, Cheng Jiaqi, Nihongaki Yuta, Idrizi Adrian, Tryggvadottir Rakel, Camacho Oscar, Shang Xingbo, Min Jimin, Koldobskiy Michael A, Maitra Anirban, Levchenko Andre, Slusher Barbara S, Ji Hongkai, Feinberg Andrew P
