日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.

PIKfyve 在 MM 中受到抑制会破坏自噬和溶酶体功能,增加 MHC 表达和胆固醇代谢。

Bonolo de Campos Cecilia, He Ruijuan, Pelino Tessa, Abelman Dor D, Li Zhihua, Lee Daniel K C, Wang Ding Yan, St Paul Michael, Bruce Jeffrey, Simpson Craig D, Wybeng-Groot Leanne, Moran Michael F, Tiedemann Rodger, Pugh Trevor, Mak Tak W, Issakova Olga, Sepetov Nikolai, Trudel Suzanne, Stewart A Keith

Hematopoietic expression of cIAP2 drives inflammation and heart failure after myocardial infarction.

心肌梗死后,cIAP2 的造血表达会引发炎症和心力衰竭。

Smyth David, Zhang Liyong, Al-Khalaf Mohammad, Robichaud Sabrina, Seymour Richard, Geoffrion Michele, Jung Richard, Parlow Simon, Du Feng, McNeill Brian, Du Qiujiang, Beauregard Caroline, Zhao Xiaoling, Ouimet Mireille, Beug Shawn T, LaCasse Eric C, Rayner Katey J, Mak Tak W, Hibbert Benjamin, Korneluk Robert G, Liu Peter P

CD28-driven ex vivo generation of stem-like memory CD8(+) T cells bypassing CD3/TCR signaling

CD28驱动的体外干细胞样记忆CD8(+) T细胞生成绕过CD3/TCR信号传导

Ihara, Fumie; Ohashi, Yota; Zheng, Evey Y F; Fukao, Saori; Rodrigo, Rowena; Noamani, Babak; Boukhaled, Giselle M; Wang, Ben X; Han, Dong-Hoon; Wei, Xinyu; Burt, Brian D; Saso, Kayoko; Matsunaga, Yukiko; Ly, Dalam; Kagoya, Yuki; Butler, Marcus O; Mak, Tak W; Saibil, Samuel D; Hirano, Naoto

Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi.

揭示 p53 变体 p53psi 的发育和肿瘤抑制作用。

Gorrini Chiara, Jafari Soode, Duncan Gordon, Snow Bryan, Hendrikse Liam, McLoughlin Louis, Haight Jillian, Wakeham Andrew, Tobin Chantal, Elia Andrew, Ramachandran Paramesh, Law Rhoda, Gang Bevan, Lu Tsai-Ling, Morgado-Palacin Isabel, You-Ten Annick, Berger Thorsten, Sordella Raffaella, Mak Tak W

Genome-Wide CRISPR Screens Identify ABCG2-Mediated Drug Resistance to the Threonine Tyrosine Kinase (TTK) Inhibitor CFI-402257 in Breast Cancer

全基因组 CRISPR 筛选发现乳腺癌中 ABCG2 介导的对苏氨酸酪氨酸激酶 (TTK) 抑制剂 CFI-402257 的耐药性

Thu, Kelsie L; Jafari, Soode; Silvester, Jennifer; Cruickshank, Jennifer; Soria-Bretones, Isabel; Hodgson, Kelsey; Tobin, Chantal; Haight, Jillian; Lau, Asa P Y; Bray, Tessa; Wakeham, Drew; Bray, Mark R; Mak, Tak W; Cescon, David W

PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis.

PTEN 调节迷走神经-胰岛素信号传导,以优化自主神经输出,从而决定外周炎症和代谢稳态。

Li Yu Zhe, Son Joe Eun, Vo Nathaniel, Bellisimo Catherine, Lee Ju Hee, Rapps Joshua, Pollock-Tahiri Evan, Ghebreselassie Martha, Chen Chuck T, Bazinet Richard P, Billia Filio, Suzuki Akira, Hui Chi-Chung, Mak Tak W, Sung Hoon-Ki, Yoo Paul, Woo Minna

The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction.

IDH1-R132H 突变通过破坏 NDUFA1 和 FSP1 的相互作用促进铁死亡,从而加剧顺铂引起的急性肾损伤

Lai Kunmei, Chen Zhimin, Lin Siyi, Ye Keng, Yuan Ying, Li Guoping, Song Yankun, Ma Huabin, Mak Tak W, Xu Yanfang

Mutant IDH1 cooperates with NPM1c or FLT3(ITD) to drive distinct myeloid diseases and molecular outcomes

突变型IDH1与NPM1c或FLT3(ITD)协同作用,驱动不同的髓系疾病和分子结果。

Sakamoto, Takashi; Leca, Julie; Zhang, Xin; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Hendrikse, Liam D; Zhou, Wenjing; Berger, Thorsten; Fortin, Jerome; Chan, Steven M; Chiang, Ming-Feng; Inoue, Satoshi; Li, Wanda Y; Chu, Mandy F; Duncan, Gordon S; Wakeham, Andrew; Lemonnier, François; Tobin, Chantal; Mcwilliam, Ryan; Colonna, Isabelle; Bontoux, Christophe; Jafari, Soode Moghadas; Bowman, Robert L; Nicolay, Brandon; Ronseaux, Sebastien; Narayanaswamy, Rohini; Levine, Ross L; Melnick, Ari M; Mason, Christopher E; Minden, Mark D; Mak, Tak W

B cell-derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor-mediated signaling.

B 细胞衍生的乙酰胆碱通过 α9 尼古丁乙酰胆碱受体介导的信号传导减轻小鼠的皮肤炎症

Foffi Erica, Rugolo Francesco, Ramamurthy Nisha, Haight Jillian, Helke Simone, You-Ten Annick, Tobin Chantal, Jafari Soode Moghadas, Elia Andrew J, Berger Thorsten, Candi Eleonora, Melino Gerry, Mak Tak W

2-Methoxyestradiol Treatment Prevents Graft-versus-Host Disease While Preserving Graft-versus-Leukemia Effect in Mice

2-甲氧基雌二醇治疗可预防小鼠移植物抗宿主病,同时保留移植物抗白血病效应

Li, Dan; Bassett, Roland; Champlin, Richard E; Molldrem, Jeffrey J; Mak, Tak W; Ma, Qing