日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Library docking for Cannabinoid-2 Receptor ligands

大麻素-2受体配体的库对接

Rachman, Moira M; Iliopoulos-Tsoutsouvas, Christos; Sacco, Michael D; Xu, Xinyu; Wu, Cheng-Guo; Santos, Emma; Glenn, Isabella S; Paris, Lu; Cahill, Michelle K; Ganapathy, Suthakar; Tummino, Tia A; Moroz, Yurii S; Radchenko, Dmytro S; Okorie, Meri; Tawfik, Vivianne; Irwin, John J; Makriyannis, Alexandros; Skiniotis, Georgios; Shoichet, Brian K

Crystal structures of agonist-bound human cannabinoid receptor CB(1)

激动剂结合的人类大麻素受体CB(1)的晶体结构

Hua, Tian; Vemuri, Kiran; Nikas, Spyros P; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A; Zhao, Suwen; Bohn, Laura M; Makriyannis, Alexandros; Stevens, Raymond C; Liu, Zhi-Jie

Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB(1)

撤稿声明:激动剂结合的人类大麻素受体 CB(1) 的晶体结构

Hua, Tian; Vemuri, Kiran; Nikas, Spyros P; Laprairie, Robert B; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A; Zhao, Suwen; Bohn, Laura M; Makriyannis, Alexandros; Stevens, Raymond C; Liu, Zhi-Jie

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

针对副作用较小的 1 型大麻素受体激动剂的虚拟库对接

Tummino Tia A, Iliopoulos-Tsoutsouvas Christos, Braz Joao M, O'Brien Evan S, Stein Reed M, Craik Veronica, Tran Ngan K, Ganapathy Suthakar, Liu Fangyu, Shiimura Yuki, Tong Fei, Ho Thanh C, Radchenko Dmytro S, Moroz Yurii S, Rosado Sian Rodriguez, Bhardwaj Karnika, Benitez Jorge, Liu Yongfeng, Kandasamy Herthana, Normand Claire, Semache Meriem, Sabbagh Laurent, Glenn Isabella, Irwin John J, Kumar Kaavya Krishna, Makriyannis Alexandros, Basbaum Allan I, Shoichet Brian K

Structural basis of THC analog activity at the Cannabinoid 1 receptor.

THC类似物在大麻素1受体上的活性结构基础

Thorsen Thor S, Kulkarni Yashraj, Sykes David A, Bøggild Andreas, Drace Taner, Hompluem Pattarin, Iliopoulos-Tsoutsouvas Christos, Nikas Spyros P, Daver Henrik, Makriyannis Alexandros, Nissen Poul, Gajhede Michael, Veprintsev Dmitry B, Boesen Thomas, Kastrup Jette S, Gloriam David E

CB(1) cannabinoid receptor agonists induce acute respiratory depression in awake mice

CB(1)大麻素受体激动剂可诱导清醒小鼠发生急性呼吸抑制

Watkins, Joshua; Aradi, Petra; Hahn, Rachel; Makriyannis, Alexandros; Mackie, Ken; Katona, Istvan; Hohmann, Andrea G

Exceptionally Potent Chiral Anandamide Analogs.

超强效手性花生四烯酸乙醇胺类似物。

Georgiadis Markos-Orestis, Ferreras Elena, Ji Lipin, Ferreira Luana Assis, Hainline John, Tong Fei, Dang Vuong Q, Faragher Alexandra, Sadybekov Anastasiia V, Bohn Laura M, Katritch Vsevolod, Hohmann Andrea G, Makriyannis Alexandros, Nikas Spyros P

Novel Tetraolefinic Chain Phenyl Substituted Endocannabinoid Probes.

新型四烯烃链苯基取代内源性大麻素探针。

Georgiadis Markos-Orestis, Ji Lipin, Tong Fei, Dang Vuong Q, Ferreira Luana Assis, Faragher Alexandra, Tran Ngan, Sadybekov Anastasiia V, Ganapathy Suthakar, Zvonok Nikolai, Katritch Vsevolod, Hohmann Andrea G, Bohn Laura M, Makriyannis Alexandros, Nikas Spyros P

P2X(7) receptor-dependent increase in endocannabinoid 2-arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism.

P2X(7)受体依赖性增加培养神经元细胞内源性大麻素2-花生四烯酸甘油酯的产生:动力学和机制

Singh Simar, Sarroza Dennis, English Anthony, Whittington Dale, Dong Ao, Malamas Michael, Makriyannis Alexandros, van der Stelt Mario, Li Yulong, Zweifel Larry, Bruchas Michael R, Land Benjamin B, Stella Nephi

AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects

AM6527 是一种中性 CB1 受体拮抗剂,可抑制啮齿动物的阿片类药物摄取和渴求,以及可卡因渴求,且无不良反应。

Soler-Cedeño, Omar; Alton, Hannah; Bi, Guo-Hua; Linz, Emily; Ji, Lipin; Makriyannis, Alexandros; Xi, Zheng-Xiong