Malek Thomas R相关文献与解析，生知库 | 链接生命科学的每一步

Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME.

一种新型的选择性抗 Notch1 中和抗体通过促进炎症性肿瘤微环境 (TME) 来阻断 Notch1，从而提高黑色素瘤免疫疗法的疗效

期刊:Journal of Experimental & Clinical Cancer Research

de Freitas Juliano Tiburcio, Thakur Varsha, LaPorte Kathryn M, Thakur Vijay S, Flores Brian, Caicedo Valentina, Ajaegbu Chioma G E, Ingrasci Giuseppe, Lipman Zoe M, Zhang Keman, Qiu Hong, Malek Thomas R, Bedogni Barbara

Fueling Cancer Vaccines to Improve T Cell-Mediated Antitumor Immunity

增强癌症疫苗以改善T细胞介导的抗肿瘤免疫

期刊:Frontiers in Oncology

影响因子:3.3

doi:10.3389/fonc.2022.878377

Hernandez, Rosmely; Malek, Thomas R

Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions

医疗手段可能会无意中改变患有广泛病理生理状况患者的调节性T细胞群。

期刊:American Journal of Pathology

影响因子:

doi:10.1016/j.ajpath.2020.07.012

Copsel, Sabrina N; Malek, Thomas R; Levy, Robert B

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

胸腺发育和外周调节性T细胞稳态所必需的、互不重叠的IL-2Rα依赖性过程

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-019-08960-1

Toomer, Kevin H; Lui, Jen Bon; Altman, Norman H; Ban, Yuguang; Chen, Xi; Malek, Thomas R

Cytokine Signaling in the Development and Homeostasis of Regulatory T cells

细胞因子信号在调节性T细胞发育和稳态中的作用

期刊:Cold Spring Harbor Perspectives in Biology

影响因子:8.4

doi:10.1101/cshperspect.a028597

Toomer, Kevin H; Malek, Thomas R

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

小鼠线粒体DNA双链瞬时断裂会以ROS依赖但p53/p21非依赖的方式导致加速衰老表型。

期刊:Cell Death and Differentiation

影响因子:15.4

doi:10.1038/cdd.2016.123

Pinto, Milena; Pickrell, Alicia M; Wang, Xiao; Bacman, Sandra R; Yu, Aixin; Hida, Aline; Dillon, Lloye M; Morton, Paul D; Malek, Thomas R; Williams, Siôn L; Moraes, Carlos T

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice

NOD小鼠体内稳态的改变和调节性T细胞亚群的发育是IL-2R依赖性的糖尿病风险因素。

期刊:Science Signaling

影响因子:6.6

doi:10.1126/scisignal.aam9563

Dwyer, Connor J; Bayer, Allison L; Fotino, Carmen; Yu, Liping; Cabello-Kindelan, Cecilia; Ward, Natasha C; Toomer, Kevin H; Chen, Zhibin; Malek, Thomas R

The Lower Limit of Regulatory CD4(+) Foxp3(+) TCRβ Repertoire Diversity Required To Control Autoimmunity

控制自身免疫所需的调节性 CD4(+) Foxp3(+) TCRβ 库多样性的下限

期刊:Journal of Immunology

影响因子:3.4

doi:10.4049/jimmunol.1601966

Yu, Aixin; Dee, Michael J; Adeegbe, Dennis; Dwyer, Connor J; Altman, Norman H; Malek, Thomas R

Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2

利用低剂量白细胞介素-2促进1型糖尿病的免疫调节

期刊:Current Diabetes Reports

影响因子:6.4

doi:10.1007/s11892-016-0739-1

Dwyer, Connor J; Ward, Natasha C; Pugliese, Alberto; Malek, Thomas R

Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer

白细胞介素-2信号通路在自身免疫和癌症中调控T细胞生物学的作用

Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME.

一种新型的选择性抗 Notch1 中和抗体通过促进炎症性肿瘤微环境 (TME) 来阻断 Notch1，从而提高黑色素瘤免疫疗法的疗效

Fueling Cancer Vaccines to Improve T Cell-Mediated Antitumor Immunity

增强癌症疫苗以改善T细胞介导的抗肿瘤免疫

Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions

医疗手段可能会无意中改变患有广泛病理生理状况患者的调节性T细胞群。

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

胸腺发育和外周调节性T细胞稳态所必需的、互不重叠的IL-2Rα依赖性过程

Cytokine Signaling in the Development and Homeostasis of Regulatory T cells

细胞因子信号在调节性T细胞发育和稳态中的作用

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

小鼠线粒体DNA双链瞬时断裂会以ROS依赖但p53/p21非依赖的方式导致加速衰老表型。

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice

NOD小鼠体内稳态的改变和调节性T细胞亚群的发育是IL-2R依赖性的糖尿病风险因素。

The Lower Limit of Regulatory CD4(+) Foxp3(+) TCRβ Repertoire Diversity Required To Control Autoimmunity

控制自身免疫所需的调节性 CD4(+) Foxp3(+) TCRβ 库多样性的下限

Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2

利用低剂量白细胞介素-2促进1型糖尿病的免疫调节