日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of affinity-optimized peptide binders of a viral protease for chemical genetic applications

鉴定用于化学遗传学应用的病毒蛋白酶亲和力优化肽结合剂

Banales-Mejia, Fernando; Dieter, Emily M; Radmall, Kyler J; Foight, Glenna W; Fowler, Douglas M; Maly, Dustin J

Late-Stage Reshaping of Phage-Displayed Libraries to Macrocyclic and Bicyclic Landscapes using a Multipurpose Linchpin

利用多功能连接枢纽对噬菌体展示文库进行后期重塑,构建大环和双环结构。

Yan, Kejia; Miskolzie, Mark; Banales Mejia, Fernando; Peng, Chuanhao; Ekanayake, Arunika I; Atrazhev, Alexey; Cao, Jessica; Maly, Dustin J; Derda, Ratmir

Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance

单细胞传感器分析揭示了Ras-G12C耐药信号通路。

Zhang, Jason Z; Ong, Shao-En; Baker, David; Maly, Dustin J

Multiplex design and discovery of proximity handles for programmable proteome editing

用于可编程蛋白质组编辑的多重设计和邻近控制点的发现

Suiter, Chase C; Ahn, Green; Chiu, Melodie; Fu, Yi; Sadre, Shayan; Simon, Jessica J; Lee, David S; Fowler, Douglas M; Maly, Dustin J; Baker, David; Shendure, Jay

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

计算机设计的传感器能够以亚细胞分辨率检测内源性Ras活性和信号效应因子。

Zhang, Jason Z; Nguyen, William H; Greenwood, Nathan; Rose, John C; Ong, Shao-En; Maly, Dustin J; Baker, David

Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq.

利用 LABEL-seq 对细胞内蛋白质丰度、活性、相互作用和成药性进行多重分析

Simon Jessica J, Fowler Douglas M, Maly Dustin J

Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics.

大规模分析 Src 激酶的耐药性,揭示了一个将自身抑制和催化结构域动力学耦合起来的调控网络

Chakraborty Sujata, Ahler Ethan, Simon Jessica J, Fang Linglan, Potter Zachary E, Sitko Katherine A, Stephany Jason J, Guttman Miklos, Fowler Douglas M, Maly Dustin J

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

一种抑制前列腺癌糖酵解的化合物可控制晚期前列腺癌的生长

Uo, Takuma; Ojo, Kayode K; Sprenger, Cynthia C; Epilepsia, Kathryn Soriano; Perera, B Gayani K; Damodarasamy, Mamatha; Sun, Shihua; Kim, Soojin; Hogan, Hannah H; Hulverson, Matthew A; Choi, Ryan; Whitman, Grant R; Barrett, Lynn K; Michaels, Samantha A; Xu, Linda H; Sun, Vicky L; Arnold, Samuel L M; Pang, Haley J; Nguyen, Matthew M; Vigil, Anna-Lena B G; Kamat, Varun; Sullivan, Lucas B; Sweet, Ian R; Vidadala, Ram; Maly, Dustin J; Van Voorhis, Wesley C; Plymate, Stephen R

Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning

通过深度突变扫描揭示了Src激酶对Hsp90依赖性的分子决定因素

Nguyen, Vanessa; Ahler, Ethan; Sitko, Katherine A; Stephany, Jason J; Maly, Dustin J; Fowler, Douglas M

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance.

单细胞信号分析表明,主要 Vault 蛋白促进 RasG12C 抑制剂耐药性

Zhang Jason Z, Ong Shao-En, Baker David, Maly Dustin J