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Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

阻断腺苷A1受体逆转Tau蛋白依赖性认知衰退：不同Tau蛋白病变程度转基因小鼠模型的比较

期刊:International Journal of Molecular Sciences

doi:10.3390/ijms24119260

Anglada-Huguet, Marta; Endepols, Heike; Sydow, Astrid; Hilgers, Ronja; Neumaier, Bernd; Drzezga, Alexander; Kaniyappan, Senthilvelrajan; Mandelkow, Eckhard; Mandelkow, Eva-Maria

Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study

在tau蛋白病小鼠模型中评估脑代谢减退、tau蛋白沉积、TSPO表达和突触密度之间的体内关系：一项多示踪剂PET研究

期刊:Molecular Neurobiology

影响因子:4.3

doi:10.1007/s12035-022-02793-8

Endepols, Heike; Anglada-Huguet, Marta; Mandelkow, Eckhard; Schmidt, Yannick; Krapf, Philipp; Zlatopolskiy, Boris D; Neumaier, Bernd; Mandelkow, Eva-Maria; Drzezga, Alexander

Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau

无偏蛋白质组学分析显示 IP3R 调节剂 AHCYL1/IRBIT 是微管相关蛋白 tau 的新型相互作用蛋白

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2022.101774

Lena Wischhof, Aasha Adhikari, Mrityunjoy Mondal, Anaïs Marsal-Cots, Jacek Biernat, Eva Maria Mandelkow, Eckhard Mandelkow, Dan Ehninger, Pierluigi Nicotera, Daniele Bano

信号转导

发表日期：2022

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Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates

疾病相关的Tau蛋白磷酸化阻碍Tau蛋白凝聚体内的微管蛋白组装

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202011157

Savastano, Adriana; Flores, David; Kadavath, Harindranath; Biernat, Jacek; Mandelkow, Eckhard; Zweckstetter, Markus

Tau and Membranes: Interactions That Promote Folding and Condensation

Tau蛋白与细胞膜：促进折叠和凝聚的相互作用

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2021.725241

Sallaberry, Chad A; Voss, Barbie J; Majewski, Jaroslaw; Biernat, Jacek; Mandelkow, Eckhard; Chi, Eva Y; Vander Zanden, Crystal M

细胞生物学

发表日期：2021

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Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display

利用镜像噬菌体展示技术筛选出针对 Tau-Repeat 2 的强效 Tau 蛋白聚集抑制剂 D-肽。

期刊:Chembiochem

影响因子:2.8

doi:10.1002/cbic.202100287

Malhis, Marwa; Kaniyappan, Senthilvelrajan; Aillaud, Isabelle; Chandupatla, Ram Reddy; Ramirez, Lisa Marie; Zweckstetter, Markus; Horn, Anselm H C; Mandelkow, Eckhard; Sticht, Heinrich; Funke, Susanne Aileen

发表日期：2021

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Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice

使用 BSc3094 抑制 Tau 蛋白聚集可降低 rTg4510 小鼠体内的 Tau 蛋白水平并减轻其认知缺陷。

期刊:Alzheimer's and Dementia: Translational Research and Clinical Interventions

影响因子:

doi:10.1002/trc2.12170

Anglada-Huguet, Marta; Rodrigues, Sara; Hochgräfe, Katja; Mandelkow, Eckhard; Mandelkow, Eva-Maria

神经科学

发表日期：2021

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FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

基于 FRET 的 Tau 接种试验并不代表 Tau 丝的朊病毒样模板组装

期刊:Molecular Neurodegeneration

影响因子:14.9

doi:10.1186/s13024-020-00389-1

Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow, Eckhard Mandelkow

微生物学

发表日期：2020

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A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

结合天然质谱和液相色谱-串联质谱的方法揭示了人Tau蛋白具有很高的固有磷酸化水平，但其他关键修饰水平极低。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.RA120.015882

Drepper, Friedel; Biernat, Jacek; Kaniyappan, Senthilvelrajan; Meyer, Helmut E; Mandelkow, Eva Maria; Warscheid, Bettina; Mandelkow, Eckhard

TDP-43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

TDP-43蛋白病与神经退行性疾病：来自秀丽隐杆线虫模型的启示

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

阻断腺苷A1受体逆转Tau蛋白依赖性认知衰退：不同Tau蛋白病变程度转基因小鼠模型的比较

Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study

在tau蛋白病小鼠模型中评估脑代谢减退、tau蛋白沉积、TSPO表达和突触密度之间的体内关系：一项多示踪剂PET研究

Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau

无偏蛋白质组学分析显示 IP3R 调节剂 AHCYL1/IRBIT 是微管相关蛋白 tau 的新型相互作用蛋白

Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates

疾病相关的Tau蛋白磷酸化阻碍Tau蛋白凝聚体内的微管蛋白组装

Tau and Membranes: Interactions That Promote Folding and Condensation

Tau蛋白与细胞膜：促进折叠和凝聚的相互作用

Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display

利用镜像噬菌体展示技术筛选出针对 Tau-Repeat 2 的强效 Tau 蛋白聚集抑制剂 D-肽。

Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice

使用 BSc3094 抑制 Tau 蛋白聚集可降低 rTg4510 小鼠体内的 Tau 蛋白水平并减轻其认知缺陷。

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

基于 FRET 的 Tau 接种试验并不代表 Tau 丝的朊病毒样模板组装

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

结合天然质谱和液相色谱-串联质谱的方法揭示了人Tau蛋白具有很高的固有磷酸化水平，但其他关键修饰水平极低。