日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Natural Product Target Identification of Wheldone, a Fungal Metabolite, as a KIF11 Inhibitor in Ovarian Cancer Using the DiffPOP (Differential Protein Precipitation) Method

利用DiffPOP(差异蛋白沉淀)法鉴定真菌代谢产物Wheldone作为卵巢癌中KIF11抑制剂的天然产物靶点

Khin, Manead; Saldana, Alejandra Cavazos; Rangel-Grimaldo, Manuel; Raja, Huzefa A; Abegg, Daniel; Ekiert, Julia; Liu, Chang; Misra, Sweta; Ratia, Kiira; Adibekian, Alexander; Gao, Yu; Kulp, Samuel K; Coss, Christopher C; Oberlies, Nicholas H; Burdette, Joanna E

Beyond Monomers: Discovery of Bioactive Naphthoquinone Heterodimers and Perenniporides from Pyrenochaetopsis Species

超越单体:从 Pyrenochaetopsis 物种中发现具有生物活性的萘醌异二聚体和 Perenniporides

Al-Qiam, Reema A; Rangel-Grimaldo, Manuel; Chauvin, Isabel M; Kaweesa, Elizabeth N; Khin, Manead; Raja, Huzefa A; Orjala, Jimmy; Burdette, Joanna E; Pearce, Cedric J; Oberlies, Nicholas H

Cytotoxic Lignan and Flavonoid Derivatives from the Branches of Beilschmiedia yunnanensis.

从云南贝氏木枝中分离得到的细胞毒性木脂素和黄酮类衍生物

Terrasson Korydwen, Addo Ermias Mekuria, Khin Manead, Ninh Tran Ngoc, Pandey Pankaj, Chittiboyina Amar G, Ferreira Daneel, Rakotondraibe Harinantenaina L, Burdette Joanna E, Soejarto Djaja D, Kinghorn A Douglas

Engineering regiospecific methylation of the pladienolides

普拉地诺内酯的区域特异性甲基化工程

Smith, Emily R; Al-Smadi, Dua H; Dai, Yitao; Khin, Manead; Burdette, Joanna E; Duggan, Brendan M; La Clair, James J; Eustáquio, Alessandra S; Burkart, Michael D

Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids.

磷酸酶和张力蛋白同源物 (PTEN) 的缺失会增加赖氨酰氧化酶样 2 (LOXL2) 的表达,从而促进输卵管上皮细胞以三维球体形式生长

Russo Angela, Moy Junlone, Khin Manead, Dorsey Timothy R, Lopez Carrero Alfredo, Burdette Joanna E

Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster

生物活性驱动的真菌代谢基因组学识别抗增殖干细胞类似物及其生物合成基因簇

Navid J Ayon, Cody E Earp, Raveena Gupta, Fatma A Butun, Ashley E Clements, Alexa G Lee, David Dainko, Matthew T Robey, Manead Khin, Lina Mardiana, Alexandra Longcake, Manuel Rangel-Grimaldo, Michael J Hall, Michael R Probert, Joanna E Burdette, Nancy P Keller, Huzefa A Raja, Nicholas H Oberlies, Ne

Aulosirazole Stimulates FOXO3a Nuclear Translocation to Regulate Apoptosis and Cell-Cycle Progression in High-Grade Serous Ovarian Cancer (HGSOC) Cells.

Aulosirazole 刺激 FOXO3a 核转位,从而调节高级别浆液性卵巢癌 (HGSOC) 细胞的凋亡和细胞周期进程

Khin Manead, Davis Lydia J, Lantvit Daniel D, Orjala Jimmy, Burdette Joanna E

Semisynthesis, Characterization, and Biological Evaluation of Fluorinated Analogues of the Spirobisnaphthalene, Diepoxin-η

螺双萘氟化类似物 Diepoxin-η 的半合成、表征及生物学评价

Pourhadi, Hadi; El-Elimat, Tamam; Rangel-Grimaldo, Manuel; Graf, Tyler N; Falkinham, Joseph O 3rd; Khin, Manead; Burdette, Joanna E; Mirtallo Ezzone, Nathan; Jeyaraj, Jonathan; de Blanco, Esperanza Carcache; Pearce, Cedric J; Oberlies, Nicholas H

Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models

探究卵巢癌模型中 Eupenifeldin 诱导的细胞毒性信号

Amanda C Maldonado, Monica A Haughan, Manead Khin, Julia Ekiert, Ziwei Zhang, Daniel Lantvit, Zeinab Y Al Subeh, Herma C Pierre, Maryna Salkovski, Tal Hirschhorn, Yu Gao, Cedric J Pearce, Brent R Stockwell, Leslie N Aldrich, Nicholas H Oberlies, Joanna E Burdette

Aulosirazoles B and C from the Cyanobacterium Nostoc sp. UIC 10771: Analogues of an Isothiazolonaphthoquinone Scaffold that Activate Nuclear Transcription Factor FOXO3a in Ovarian Cancer Cells

蓝藻 Nostoc sp. UIC 10771 中的 Aulosirazoles B 和 C:异噻唑啉醌支架的类似物,可激活卵巢癌细胞中的核转录因子 FOXO3a

Lydia J Davis, Amanda C Maldonado, Manead Khin, Aleksej Krunic, Joanna E Burdette, Jimmy Orjala