日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity

基于 CDK7 共价结合药物的抗疱疹病毒宿主导向策略:靶向选择性、皮摩尔剂量、跨病毒反应性

DongHoon Yu, Sabrina Wagner, Martin Schütz, Yeejin Jeon, Mooyoung Seo, Jaeseung Kim, Nadine Brückner, Jintawee Kicuntod, Julia Tillmanns, Christina Wangen, Friedrich Hahn, Benedikt B Kaufer, Frank Neipel, Jan Eickhoff, Bert Klebl, Kiyean Nam, Manfred Marschall

Establishment of a Luciferase-Based Reporter System to Study Aspects of Human Cytomegalovirus Infection, Replication Characteristics, and Antiviral Drug Efficacy

建立基于荧光素酶的报告系统来研究人类巨细胞病毒感染、复制特性和抗病毒药物疗效

Julia Tillmanns, Jintawee Kicuntod, Antonia Ehring, Endrit Elbasani, Eva Maria Borst, Debora Obergfäll, Regina Müller, Friedrich Hahn, Manfred Marschall

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

共价结合弹头化合物在巨细胞病毒核出口复合物作为抗病毒靶点的验证中的评估

Julia Tillmanns, Sigrun Häge, Eva Maria Borst, Julia Wardin, Jan Eickhoff, Bert Klebl, Sabrina Wagner, Christina Wangen, Friedrich Hahn, Eileen Socher, Manfred Marschall

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

巨细胞病毒细胞周期蛋白依赖性激酶直系同源物 vCDK/pUL97 与人类细胞周期蛋白 H 和 CDK7 发生调节相互作用,共同决定病毒复制效率

Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T Hamilton, William D Rawlinson, Heinrich Sticht, Manfred Marschall

The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7-Cyclin H Determines Individual Patterns of Transcription in Infected Cells

巨细胞病毒激酶 vCDK/pUL97 与宿主因子 CDK7-Cyclin H 之间的相互作用复合物决定了受感染细胞中的个体转录模式

Martin Schütz, Arne Cordsmeier, Christina Wangen, Anselm H C Horn, Emanuel Wyler, Armin Ensser, Heinrich Sticht, Manfred Marschall

'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis

通过随机诱变鉴定的疱疹病毒核心核出口复合物的“共享钩”和“改变钩”结合活性

Josephine Lösing, Sigrun Häge, Martin Schütz, Sabrina Wagner, Julia Wardin, Heinrich Sticht, Manfred Marschall

The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity

水痘-带状疱疹病毒 Orf24-Orf27 核出口复合物的晶体结构揭示了疱疹病毒亚家族特异性的多个决定因素

Johannes Schweininger, Mark Kriegel, Sigrun Häge, Marcus Conrad, Sewar Alkhashrom, Josephine Lösing, Sigrid Weiler, Julia Tillmanns, Claudia Egerer-Sieber, Andrea Decker, Tihana Lenac Roviš, Jutta Eichler, Heinrich Sticht, Manfred Marschall, Yves A Muller

The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors

巨细胞病毒核心核外流蛋白的寡聚组装体与宿主激酶相关,并对抗病毒激酶抑制剂具有敏感性

Jintawee Kicuntod, Sigrun Häge, Friedrich Hahn, Heinrich Sticht, Manfred Marschall

Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses

表达模拟敏感激酶 pUL97 的重组人巨细胞病毒作为功能分析的新工具

Nadine Krämer, Martin Schütz, Uxía Gestal Mato, Lina Herhaus, Manfred Marschall, Christine Zimmermann

Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations

细胞周期蛋白依赖性激酶 (CDK) 和人类巨细胞病毒编码的 CDK 直系同源物 pUL97 是协同药物组合极具吸引力的靶点

Markus Wild, Friedrich Hahn, Nadine Brückner, Martin Schütz, Christina Wangen, Sabrina Wagner, Mona Sommerer, Stefan Strobl, Manfred Marschall