日期 影响因子
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影响因子:
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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₠).

四氢萘啶和二氢萘啶酮醚作为代谢型谷氨酸受体 5 (mGluâ‚) 的正向变构调节剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm500259z
Turlington Mark, Malosh Chrysa, Jacobs Jon, Manka Jason T, Noetzel Meredith J, Vinson Paige N, Jadhav Satyawan, Herman Elizabeth J, Lavreysen Hilde, Mackie Claire, Bartolomé-Nebreda José M, Conde-Ceide Susana, Martín-Martín M Luz, Tong Han Min, López Silvia, MacDonald Gregor J, Steckler Thomas, Daniels J Scott, Weaver C David, Niswender Colleen M, Jones Carrie K, Conn P Jeffrey, Lindsley Craig W, Stauffer Shaun R
代谢
发表日期：2014
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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

八氢吡咯并[3,4-c]吡咯类化合物是mGlu1的负变构调节剂。

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2013.07.029
Manka, Jason T; Rodriguez, Alice L; Morrison, Ryan D; Venable, Daryl F; Cho, Hyekyung P; Blobaum, Anna L; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Emmitte, Kyle A
发表日期：2013
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Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety

VU0409106 的发现：一种 mGlu5 的负变构调节剂，在焦虑小鼠模型中具有活性。

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2013.09.001
Felts, Andrew S; Rodriguez, Alice L; Morrison, Ryan D; Venable, Daryl F; Manka, Jason T; Bates, Brittney S; Blobaum, Anna L; Byers, Frank W; Daniels, J Scott; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Emmitte, Kyle A
发表日期：2013
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Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

mGlu5正变构调节剂醚系列的优化：MPEP位点相互作用交叉的分子决定因素

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2012.08.043
Manka, Jason T; Vinson, Paige N; Gregory, Karen J; Zhou, Ya; Williams, Richard; Gogi, Kiran; Days, Emily; Jadhav, Satya; Herman, Elizabeth J; Lavreysen, Hilde; Mackie, Claire; Bartolomé, José M; Macdonald, Gregor J; Steckler, Thomas; Daniels, J Scott; Weaver, C David; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R
发表日期：2012
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Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold

基于芳基乙炔双环内酰胺骨架的中枢活性mGlu5正向变构调节剂的合成及构效关系研究

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2011.01.044
Williams, Richard; Manka, Jason T; Rodriguez, Alice L; Vinson, Paige N; Niswender, Colleen M; Weaver, C David; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R
发表日期：2011
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