Mankai相关文献与解析，生知库 | 链接生命科学的每一步

Xue, Feng; Ju, Mankai; Zhu, Tienan; Zhou, Zeping; Sun, Jing; Yang, Linhua; Yan, Zhenyu; Zhou, Hu; Du, Xin; Zheng, ChangCheng; Zheng, Jing; Wu, Xia; Du, Zengmin; Jiang, Wei; Yang, Caifeng; Xiao, Xiao; Liu, Wei; Yang, Renchi; Zhang, Lei

发表日期：2026

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Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

受损的造血干细胞异质性是原发性血小板增多症发展的根本原因

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202505249

Tong, Jingyuan; Wang, Di; Song, Haoze; Sun, Ting; Zhao, Yanhong; Gu, Wenjing; Lin, Lexuan; Zhao, Yitong; Liang, Yipeng; Jin, Xu; Fu, Rongfeng; Ju, Mankai; Gao, Jie; Ma, Jinfa; Gao, Chengjie; Zhang, Anqi; Xiao, Zhijian; Jiang, Erlie; Yang, Renchi; Ma, Shihui; Zhang, Lei; Shi, Lihong

Daratumumab in patients with immune thrombocytopenia: a single-center, open-label, phase 2 trial

Daratumumab治疗免疫性血小板减少症患者：一项单中心、开放标签的II期试验

期刊:EClinicalMedicine

影响因子:10

doi:10.1016/j.eclinm.2026.103849

Chen, Yunfei; Hua, Zhengjie; Xu, Yanmei; Chen, Jia; Wen, Qing; Sun, Ting; Li, Huiyuan; Liu, Xiaofan; Fu, Rongfeng; Ju, Mankai; Xue, Feng; Liu, Wei; Dong, Huan; Gu, Wenjing; Dai, Xinyue; Wang, Wentian; Chi, Ying; Pei, Xiaolei; Yang, Renchi; Zhang, Lei

Association of immuno-inflammatory biomarkers with response to neoadjuvant chemotherapy and prognosis in HER2-positive breast cancer: dual-center clinical evidence

免疫炎症生物标志物与HER2阳性乳腺癌新辅助化疗反应和预后的相关性：双中心临床证据

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1751072

Wu, Xuanlin; Wu, Siqi; Tang, Mankai; Xie, Longgui; Liu, Jianhui; Liao, Jiexu; Wang, Jie; Yang, Huawei

Long-term efficacy and safety of low-dose rituximab in immune thrombocytopenia: a multicentre, prospective, open-label, randomised controlled trial

低剂量利妥昔单抗治疗免疫性血小板减少症的长期疗效和安全性：一项多中心、前瞻性、开放标签、随机对照试验

期刊:Annals of Hematology

影响因子:2.4

doi:10.1007/s00277-026-06908-2

Chen, Yunfei; Liu, Jiaying; Dai, Jiawen; Sun, Ting; Qiao, Zijian; Wang, Maosheng; Zhou, Hu; Zhou, Zeping; Liu, Xiaofan; Fu, Rongfeng; Xue, Feng; Liu, Wei; Ju, Mankai; Dong, Huan; Dai, Xinyue; Gu, Wenjing; Yang, Renchi; Zhang, Lei

Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia: multicentre, randomised, placebo controlled, phase 2 trial

抗CD38单克隆抗体CM313治疗原发性免疫性血小板减少症：一项多中心、随机、安慰剂对照的II期临床试验

期刊:Bmj-British Medical Journal

影响因子:42.7

doi:10.1136/bmj-2025-084314

Chen, Yunfei; Xu, Yanmei; Dai, Jiawen; Sun, Ting; Li, Huiyuan; Hua, Zhengjie; Zhou, Zeping; Zhou, Hu; Yan, Zhenyu; Zhao, Xingli; Xue, Feng; Liu, Wei; Liu, Xiaofan; Fu, Rongfeng; Wang, Wentian; Chi, Ying; Dong, Huan; Ju, Mankai; Dai, Xinyue; Gu, Wenjing; Pei, Xiaolei; Yang, Renchi; Zhang, Lei

Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow

巨噬细胞来源的双调蛋白诱导骨髓中金黄色葡萄球菌脓肿附近脂肪生成谱系前体细胞向肌成纤维细胞转化

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-63551-7

Bingsheng Yang #,Jianwen Su #,Jichang Wu #,Zhongwen Wang,Jin Hu,Mankai Yang,Yihuang Lin,Mingchao Jin,Xiaochun Bai,Bin Yu,Xianrong Zhang

The protective role of adipogenic lineage precursors in maintaining bone marrow redox homeostasis in a mouse model of prenatal dexamethasone exposure

在产前地塞米松暴露的小鼠模型中，脂肪生成谱系前体细胞在维持骨髓氧化还原稳态中的保护作用

期刊:Redox Biology

影响因子:10.7

doi:10.1016/j.redox.2025.103820

Jianwen Su ，Sushuang Ma ，Mankai Yang ，Jichang Wu ，Yijie Chen ，Mingchao Jin ，Qin Shi ，Xianrong Zhang

Mouse

发表日期：2025

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CDKN1A as a potential target for Eltrombopag treatment in ITP and its regulation of the communication between macrophages and transitional B cells in ITP

CDKN1A作为ITP中Eltrombopag治疗的潜在靶点及其对ITP中巨噬细胞和过渡性B细胞之间通讯的调控

期刊:Annals of Hematology

影响因子:2.4

doi:10.1007/s00277-025-06436-5

Wang, Shixuan; Ju, Mankai; Kong, Fancong; Jiang, Yuhuan; Tu, Yechao; Zou, Jingyun; Zou, Zhiming; Tan, Genmei; Li, Fei

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

人脐带间充质干细胞治疗难治性免疫性血小板减少症的疗效和安全性：一项前瞻性、单臂、I期试验

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-024-01793-5

Chen, Yunfei; Xu, Yanmei; Chi, Ying; Sun, Ting; Gao, Yuchen; Dou, Xueqing; Han, Zhibo; Xue, Feng; Li, Huiyuan; Liu, Wei; Liu, Xiaofan; Dong, Huan; Fu, Rongfeng; Ju, Mankai; Dai, Xinyue; Wang, Wentian; Ma, Yueshen; Song, Zhen; Gu, Jundong; Gong, Wei; Yang, Renchi; Zhang, Lei

Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials

IX因子-Padua AAV基因疗法治疗B型血友病：1/2期和3期试验

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

受损的造血干细胞异质性是原发性血小板增多症发展的根本原因

Daratumumab in patients with immune thrombocytopenia: a single-center, open-label, phase 2 trial

Daratumumab治疗免疫性血小板减少症患者：一项单中心、开放标签的II期试验

Association of immuno-inflammatory biomarkers with response to neoadjuvant chemotherapy and prognosis in HER2-positive breast cancer: dual-center clinical evidence

免疫炎症生物标志物与HER2阳性乳腺癌新辅助化疗反应和预后的相关性：双中心临床证据

Long-term efficacy and safety of low-dose rituximab in immune thrombocytopenia: a multicentre, prospective, open-label, randomised controlled trial

低剂量利妥昔单抗治疗免疫性血小板减少症的长期疗效和安全性：一项多中心、前瞻性、开放标签、随机对照试验

Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia: multicentre, randomised, placebo controlled, phase 2 trial

抗CD38单克隆抗体CM313治疗原发性免疫性血小板减少症：一项多中心、随机、安慰剂对照的II期临床试验

Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow

巨噬细胞来源的双调蛋白诱导骨髓中金黄色葡萄球菌脓肿附近脂肪生成谱系前体细胞向肌成纤维细胞转化

The protective role of adipogenic lineage precursors in maintaining bone marrow redox homeostasis in a mouse model of prenatal dexamethasone exposure

在产前地塞米松暴露的小鼠模型中，脂肪生成谱系前体细胞在维持骨髓氧化还原稳态中的保护作用

CDKN1A as a potential target for Eltrombopag treatment in ITP and its regulation of the communication between macrophages and transitional B cells in ITP

CDKN1A作为ITP中Eltrombopag治疗的潜在靶点及其对ITP中巨噬细胞和过渡性B细胞之间通讯的调控

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

人脐带间充质干细胞治疗难治性免疫性血小板减少症的疗效和安全性：一项前瞻性、单臂、I期试验