日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency

siRNA的非环状丝氨醇核酸修饰可克服种子区介导的脱靶效应，同时保持效力。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkag345
Chickering, Tyler; Harp, Joel M; Jiang, Yongfeng; Qin, June; He, Guo; Hyde, Sarah; Ihlefeld, Audrey; Janas, Maja; O'Flaherty, Derek K; Schofield, Sally; Szeto, John; Theile, Christopher S; Charissé, Klaus; Jadhav, Vasant; Maier, Martin A; Manoharan, Muthiah; Egli, Martin; Schlegel, Mark K
发表日期：2026
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Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity

含碳环核苷酸的siRNA的合成及环戊烷构象在RNAi活性中的作用

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d6cb00038j
Kundu, Jayanta; Datta, Dhrubajyoti; Akabane-Nakata, Masaaki; Mandal, Soham; Krampert, Monika; Egli, Martin; Manoharan, Muthiah
发表日期：2026
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Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs

修饰型未靶向核酸（MUNA）可减轻小干扰RNA的脱靶效应

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf937
Mori, Shohei; Datta, Dhrubajyoti; Perkins, Lydia; Jung, Michelle; Woods, Lauren Blair; Eaton, Alex; Qin, June; Racie, Tim; Kim, MaryBeth; Guenther, Dale C; Castoreno, Adam; Schlegel, Mark K; Charisse, Klaus; Egli, Martin; Matsuda, Shigeo; Manoharan, Muthiah
发表日期：2025
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Modulation of TTR gene expression in the eye using modified siRNAs

利用修饰的siRNA调控眼部TTR基因表达

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf409
Hu, Jiaxin; Gong, Xin; Kundu, Jayanta; Datta, Dhrubajyoti; Egli, Martin; Manoharan, Muthiah; Mootha, V Vinod; Corey, David R
信号转导
发表日期：2025
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C‑Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH

C-核苷通过降低2'-OH的亲核性来稳定RNA。

期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.5c01345
Banerjee, Dipanwita; Xiao, Lu; Thacker, Pavitra S; Kundu, Jayanta; Manoharan, Muthiah; Kool, Eric T
发表日期：2025
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C-Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH

C-核苷通过降低2'-OH的亲核性来稳定RNA。

期刊:
影响因子:
doi:10.1101/2025.07.23.666442
Banerjee, Dipanwita; Xiao, Lu; Thacker, Pavitra S; Kundu, Jayanta; Manoharan, Muthiah; Kool, Eric T
发表日期：2025
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Modulation of TTR Gene Expression in the Eye using Modified Duplex RNAs

利用修饰的双链RNA调控眼部TTR基因表达

期刊:
影响因子:
doi:10.1101/2025.03.11.642595
Hu, Jiaxin; Gong, Xin; Kundu, Jayanta; Datta, Dhrubajyoti; Egli, Martin; Manoharan, Muthiah; Mootha, V Vinod; Corey, David R
信号转导
发表日期：2025
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Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications

磷酸硫酯键结合的、含吗啉代LNA修饰的GalNAc偶联正义链的siRNA具有更高的体内代谢稳定性和沉默效率

期刊:Organic Letters
影响因子:5
doi:10.1021/acs.orglett.4c02903
Datta, Dhrubajyoti; Kumar, Pawan; Kundu, Jayanta; Qin, June; Gilbert, Jason A; Schofield, Sally; Donnelly, Daniel P; Liu, Ju; Degaonkar, Rohan; Egli, Martin; Manoharan, Muthiah
代谢
发表日期：2024
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Helical Twists in 70 Years of Nucleic Acids Research

核酸研究中的螺旋扭曲现象（70 年研究）

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.4c03540
Ganesh, Krishna; Manoharan, Muthiah
发表日期：2024
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Chemistry, structure and function of approved oligonucleotide therapeutics

已批准的寡核苷酸疗法的化学性质、结构和功能

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkad067
Egli, Martin; Manoharan, Muthiah
发表日期：2023
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