日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

将DNA-LNP靶向内皮细胞可提高表达强度、持续时间和特异性

Marzolini, Nicolas; Brysgel, Taylor V; Rahman, Ryan J; Essien, Eno-Obong; Nwe, Saw Y; Wu, Jichuan; Majumder, Aparajeeta; Patel, Manthan N; Tiwari, Sachchidanand; Espy, Carolann L; Dong, Fengyi; Santos-De León, Sabrina A; Shah, Anit; Shuvaev, Vladimir V; Hood, Elizabeth D; Chase, Liam S; Weissman, Drew; Katzen, Jeremy B; Frank, David B; Bennett, Mariko L; Marcos-Contreras, Oscar A; Myerson, Jacob W; Muzykantov, Vladimir R; Reyes-Esteves, Sahily; Brenner, Jacob S

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.

限制内体损伤感知可减少脂质纳米颗粒内体逃逸引发的炎症

Omo-Lamai Serena, Wang Yufei, Patel Manthan N, Milosavljevic Aleksa, Zuschlag Daniel, Poddar Subhajit, Wu Jichuan, Wang Liuqian, Dong Fengyi, Espy Carolann, Majumder Aparajeeta, Essien Eno-Obong, Shen Mengwen, Channer Breana, Papp Tyler E, Tobin Michael, Maheshwari Rhea, Jeong Sumin, Patel Sofia, Shah Anit, Murali Shruthi, Chase Liam S, Zamora Marco E, Arral Mariah L, Marcos-Contreras Oscar A, Myerson Jacob W, Hunter Christopher A, Discher Dennis, Gaskill Peter J, Tsourkas Andrew, Muzykantov Vladimir R, Brodsky Igor, Shin Sunny, Whitehead Kathryn A, Parhiz Hamideh, Katzen Jeremy, Miner Jonathan J, Trauner Dirk, Brenner Jacob S

Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids

利用负载内源性抗炎脂质的脂质纳米颗粒进行更安全的非病毒DNA递送

Manthan N Patel # ,Sachchidanand Tiwari # ,Yufei Wang ,Sarah O'Neill ,Jichuan Wu ,Serena Omo-Lamai ,Carolann Espy ,Liam S Chase ,Aparajeeta Majumder ,Evan Hoffman ,Anit Shah ,András Sárközy ,Jeremy Katzen ,Norbert Pardi ,Jacob S Brenner

Perspective: Advancing safe and effective DNA therapeutics using bioactive lipid nanoparticles

展望:利用生物活性脂质纳米颗粒推进安全有效的DNA疗法

Patel, Manthan N; Tiwari, Sachchidanand; Brenner, Jacob S

Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage

含有IL-10 mRNA的靶向脂质纳米颗粒可改善实验性脑出血的预后

Reyes-Esteves, Sahily; Majumder, Aparajeeta; Marzolini, Nicolas; Zamora, Marco E; Jeong, Soomin; Wang, Yufei; Patel, Manthan N; Espy, Carolann; Papp, Tyler Ellis; Akyianu, Awurama; Nong, Jia; Messe, Lawson; Omo-Lamai, Serena; Parhiz, Hamideh; Myerson, Jacob W; Marcos-Contreras, Oscar A; Brenner, Jacob S

Preparation and Characterization of Lipid Nanoparticles Co-loaded With DNA and Nitro-Oleic Acid.

DNA与硝基油酸共负载脂质纳米粒子的制备与表征。

Patel Manthan N, Tiwari Sachchidanand, Brenner Jacob S

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions.

脂质纳米颗粒向肺部的物理化学靶向作用可诱导凝血:机制和解决方案

Omo-Lamai Serena, Zamora Marco E, Patel Manthan N, Wu Jichuan, Nong Jia, Wang Zhicheng, Peshkova Alina, Majumder Aparajeeta, Melamed Jilian R, Chase Liam S, Essien Eno-Obong, Weissman Drew, Muzykantov Vladimir R, Marcos-Contreras Oscar A, Myerson Jacob W, Brenner Jacob S

Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System.

肺部边缘中性粒细胞有效地竞争靶向内皮的纳米颗粒,作为网状内皮系统的一部分发挥作用

Zamora Marco E, Essien Eno-Obong, Bhamidipati Kartik, Murthy Aditi, Liu Jing, Kim Hyunjun, Patel Manthan N, Nong Jia, Wang Zhicheng, Espy Carolann, Chaudhry Fatima N, Ferguson Laura T, Tiwari Sachchidanand, Hood Elizabeth D, Marcos-Contreras Oscar A, Omo-Lamai Serena, Shuvaeva Tea, Arguiri Evguenia, Wu Jichuan, Rauova Lubica, Poncz Mortimer, Basil Maria C, Cantu Edward, Planer Joseph D, Spiller Kara, Zepp Jarod, Muzykantov Vladimir R, Myerson Jacob W, Brenner Jacob S

Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy

纳米载体通过重新分配血液亚隔室中的药物,来改善药物的药代动力学、安全性和疗效。

Zaleski, Michael H; Omo-Lamai, Serena; Nong, Jia; Chase, Liam S; Myerson, Jacob W; Glassman, Patrick M; Lee, Florence; Reyes-Esteves, Sahily; Wang, Zhicheng; Patel, Manthan N; Peshkova, Alina D; Komatsu, Hiroaki; Axelsen, Paul H; Muzykantov, Vladimir R; Marcos-Contreras, Oscar A; Brenner, Jacob S

Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting

脂质纳米颗粒的物理化学趋向性和亲和力靶向性的结合增强了其器官靶向性

Zamora, Marco E; Omo-Lamai, Serena; Patel, Manthan N; Wu, Jichuan; Arguiri, Evguenia; Muzykantov, Vladmir R; Myerson, Jacob W; Marcos-Contreras, Oscar A; Brenner, Jacob S