日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Novel, Potent, and Orally Bioavailable SMARCA2 Proteolysis-Targeting Chimeras with Synergistic Antitumor Activity in Combination with Kirsten Rat Sarcoma Viral Oncogene Homologue G12C Inhibitors

发现新型、高效、口服生物利用度高的SMARCA2蛋白水解靶向嵌合体,与Kirsten大鼠肉瘤病毒癌基因同源物G12C抑制剂联合使用具有协同抗肿瘤活性

Sasikumar Kotagiri ,Yawen Wang ,Yanyan Han ,Xiaobing Liang ,Nicholas Blazanin ,Hira Mazhar ,Manu Sebastian ,Phuong Kieu Nguyen ,Yongying Jiang ,Yonathan Lissanu

Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters

多抗原鼻内疫苗可预防沙贝病毒感染并阻止病毒在仓鼠体内传播。

Ankita Leekha # ,Arash Saeedi # ,K M Samiur Rahman Sefat ,Monish Kumar ,Melisa Martinez-Paniagua ,Adrian Damian ,Rohan Kulkarni ,Kate Reichel ,Ali Rezvan ,Shalaleh Masoumi ,Xinli Liu ,Laurence J N Cooper ,Manu Sebastian ,Courtney M Sands ,Vallabh E Das ,Nimesh B Patel ,Brett Hurst ,Navin Varadarajan

An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models

鼻内纳米颗粒STING激动剂可在动物模型中预防呼吸道病毒感染

Ankita Leekha ,Arash Saeedi ,Monish Kumar ,K M Samiur Rahman Sefat ,Melisa Martinez-Paniagua ,Hui Meng ,Mohsen Fathi ,Rohan Kulkarni ,Kate Reichel ,Sujit Biswas ,Daphne Tsitoura ,Xinli Liu ,Laurence J N Cooper ,Courtney M Sands ,Vallabh E Das ,Manu Sebastian ,Brett L Hurst ,Navin Varadarajan

Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer

长春新碱可增强MEK抑制剂在KRAS突变型结直肠癌临床前模型中的疗效

Susmita Ghosh ,Fan Fan ,Reid T Powell ,Jason Roszik ,Yong Sung Park ,Clifford Stephan ,Manu Sebastian ,Lin Tan ,Alexey V Sorokin ,Philip L Lorenzi ,Scott Kopetz ,Lee M Ellis ,Rajat Bhattacharya

Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma

SND1甲基精氨酸读取功能丧失赋予了对肝细胞癌的抗性

Tanner Wright #, Yalong Wang #, Sabrina A Stratton, Manu Sebastian, Bin Liu, David G Johnson, Mark T Bedford

Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response

缺陷的 DNA 聚合酶 β 会引发细胞质 DNA 介导的炎症反应

Shengyuan Zhao, Julia A Goewey Ruiz, Manu Sebastian, Dawit Kidane

SPINDOC binds PARP1 to facilitate PARylation

SPINDOC 结合 PARP1 以促进 PARylation

Fen Yang, Jianji Chen, Bin Liu, Guozhen Gao, Manu Sebastian, Collene Jeter, Jianjun Shen, Maria D Person, Mark T Bedford

Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development

在结直肠癌小鼠模型中,舒林酸加磷脂可有效减少息肉,且比单独使用舒林酸更安全

Jennifer S Davis, Preeti Kanikarla-Marie, Mihai Gagea, Patrick L Yu, Dexing Fang, Manu Sebastian, Peiying Yang, Ernest Hawk, Roderick Dashwood, Lenard M Lichtenberger, David Menter, Scott Kopetz

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies

小鼠B细胞中Wwox基因缺失导致基因组不稳定、肿瘤转化和单克隆丙种球蛋白病

Kevin M McBride ,Hyunsuk Kil ,Yunxiang Mu ,Joshua B Plummer ,Jaeho Lee ,Maciej J Zelazowski ,Manu Sebastian ,Martin C Abba ,C Marcelo Aldaz

Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice

DNA 聚合酶 β 突变导致小鼠自发性染色体不稳定和炎症相关致癌作用

Shengyuan Zhao, Alex W Klattenhoff, Megha Thakur, Manu Sebastian, Dawit Kidane