Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors
以沙门氏菌为基础,靶向吲哚胺2,3-双加氧酶,并结合酶促清除肿瘤透明质酸,可诱导侵袭性胰腺肿瘤完全消退。
期刊:Cancer Immunology Research
影响因子:8.2
doi:10.1158/2326-6066.CIR-14-0214
Manuel, Edwin R; Chen, Jeremy; D'Apuzzo, Massimo; Lampa, Melanie G; Kaltcheva, Teodora I; Thompson, Curtis B; Ludwig, Thomas; Chung, Vincent; Diamond, Don J