日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

双特异性 sigma-1 受体拮抗剂和 mu-阿片受体部分激动剂:WLB-73502,一种与强效阿片类药物相比疗效和安全性均有提高的止痛药

Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, José Miguel Vela

Development of a Novel σ1 Receptor Biosensor Based on Its Heterodimerization with Binding Immunoglobulin Protein in Living Cells

基于与活细胞内结合免疫球蛋白异源二聚化的新型σ1受体生物传感器的开发

Xavier Morató, Víctor Fernández-Dueñas, Pilar Pérez-Villamor, Marta Valle-León, José Miguel Vela, Manuel Merlos, Javier Burgueño, Francisco Ciruela

Identification of Sodium Transients Through NaV1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons

通过 NaV1.5 通道识别钠瞬变作为永生化背根神经节神经元分化的调节剂

Antón L Martínez, José Brea, Eduardo Domínguez, María J Varela, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño, Ángel Carracedo, María Isabel Loza

Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition

两种纤维肌痛样病症小鼠模型中的长期反射性和非反射性疼痛反应

Beltrán Álvarez-Pérez #, Meritxell Deulofeu #, Judit Homs, Manuel Merlos, José Miguel Vela, Enrique Verdú, Pere Boadas-Vaello

EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration

两种新型Sigma-1受体配体EST79232和EST79376在运动神经元退行性变模型中发挥神经保护作用。

Núria Gaja-Capdevila ,Neus Hernández ,Sandra Yeste ,Raquel F Reinoso ,Javier Burgueño ,Ana Montero ,Manuel Merlos ,José M Vela ,Mireia Herrando-Grabulosa ,Xavier Navarro

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

在纤维肌痛样小鼠模型中,通过重复施用 Sigma-1 受体拮抗剂 BD1063 实现持久的伤害性疼痛调节

Beltrán Álvarez-Pérez, Anna Bagó-Mas, Meritxell Deulofeu, José Miguel Vela, Manuel Merlos, Enrique Verdú, Pere Boadas-Vaello

Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening

开发一种新型体外检测方法来筛选针对医源性神经突缩短的神经保护药物

Antón L Martínez, José Brea, Mateo Barro, Xavier Monroy, Manuel Merlos, Javier Burgueño, María Isabel Loza

Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice

Sigma 1 受体配体对小鼠脊髓根损伤后运动神经元死亡的神经保护作用

Núria Gaja-Capdevila, Neus Hernández, Daniel Zamanillo, Jose Miguel Vela, Manuel Merlos, Xavier Navarro, Mireia Herrando-Grabulosa

Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain

Sigma-1 受体调节小鼠骨关节炎疼痛模型中与机械超敏反应和阿片类药物耐受性相关的神经炎症

Mireia Carcolé, Sami Kummer, Leonor Gonçalves, Daniel Zamanillo, Manuel Merlos, Anthony H Dickenson, Begoña Fernández-Pastor, David Cabañero, Rafael Maldonado

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels

配体发挥偏向活性来调节 Sigma 1 受体与阳离子 TRPA1、TRPV1 和 TRPM8 通道的相互作用

Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón