日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

DNMT2-m5C-ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation-Mediated Notch Pathway

DNMT2-m5C-ACLY轴通过组蛋白乙酰化介导的Notch通路促进肝细胞癌对乐伐替尼的耐药性

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202515931
Yang, Shiguang; Li, Jie; Mao, Shengwei; Zhao, Xuhui; Liu, Douwaner; Chen, Jiafeng; Fu, Jialu; Bu, Yichao; Wu, Xiaoling; Liu, Shaoqing; Yu, Qifeng; Dong, Qiongzhu; Tang, Zheng; Fang, Yuan; Shi, Yinghong
m6A/m5C/m7G
肿瘤
表观遗传
肿瘤免疫
Notch
信号转导
乙酰化
细胞生物学
发表日期：2026
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Metabolism archetype cancer cells induce protumor TREM2(+) macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma.

代谢原型癌细胞通过oxLDL介导的代谢相互作用诱导肝细胞癌中的促肿瘤TREM2(+)巨噬细胞

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-62132-y
Chu Tianhao, Zhu Guiqi, Tang Zheng, Qu Weifeng, Yang Rui, Pan Haiting, Wang Yi, Tian Ruilin, Chen Leilei, Guan Zhiqi, Bu Yichao, Zhao Qianfu, Chen Jiafeng, Mao Shengwei, Fang Yuan, Gao Jun, Wu Xiaoling, Zhou Jian, Liu Weiren, Ye Dan, Fan Jia, Shi Yinghong
代谢
细胞生物学
肿瘤
巨噬细胞
发表日期：2025
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Targeting Deltex E3 Ubiquitin Ligase 2 Inhibits Tumor-associated Neutrophils and Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy

靶向 Deltex E3 泛素连接酶 2 可抑制肿瘤相关中性粒细胞并增强肝细胞癌细胞对免疫疗法的敏感性

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202408233
Wu, Xiaoling; Chen, Jiafeng; Chen, Yiran; Song, Shushu; Fang, Yuan; Mao, Shengwei; Gao, Jun; Zhu, Guiqi; Qu, Weifeng; Zhao, Qianfu; Yang, Rui; Guan, Zhiqi; Chu, Tianhao; Bu, Yichao; Wang, Yi; Chen, Fangyu; Zhou, Jian; Fan, Jia; Tang, Zheng; Liu, Weiren; Ruan, Yuanyuan; Shi, Yinghong
肿瘤
中性粒细胞
肿瘤免疫
粒细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Targeting CREB3L2-mediated lipid metabolism overcomes lenvatinib resistance and attenuates the progression of hepatocellular carcinoma

靶向 CREB3L2 介导的脂质代谢可克服乐伐替尼耐药性并减缓肝细胞癌的进展。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08250-3
Yang, Shiguang; Liu, Shaoqing; Li, Jie; Mao, Shengwei; Yu, Qifeng; Zhao, Xuhui; Wu, Xiaoling; Chen, Jiafeng; Bu, Yichao; Liu, Weiren; Fang, Yuan; Shi, Yinghong
肿瘤
肿瘤免疫
代谢
CREB
细胞生物学
发表日期：2025
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Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma

m5C修饰调控因子的景观分析揭示了DNMT1介导的肝细胞癌中嘧啶代谢紊乱

期刊:Clinical Epigenetics
影响因子:4.4
doi:10.1186/s13148-025-01956-3
Zhao, Xuhui; Mao, Shengwei; Fang, Yuan; Chen, Jiafeng; Bi, Lifu; Li, Jie; Wu, Jinglei; Gao, Jun; Yang, Shiguang; Fu, Jialu; Wu, Xiaoling; Zhu, Guiqi; Tang, Zheng; Shi, Yinghong; Zhou, Jian; Fan, Jia; Zhang, Xingxing; Jiang, Jinling; Liu, Weiren
m6A/m5C/m7G
肿瘤
肿瘤免疫
信号转导
代谢
DNMT1
细胞生物学
发表日期：2025
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