Structure-Based Design and Optimization Lead to the Identification of a Novel Potent sEH Inhibitor with PPARγ Partial Agonist Activity against Inflammatory and Metabolic-Related Diseases
基于结构的优化设计鉴定出一种新型强效sEH抑制剂,该抑制剂具有PPARγ部分激动剂活性,可用于治疗炎症和代谢相关疾病。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00402
Cao, Ruolin; Zhang, Maoying; Qi, Minggang; Zhang, Zhen; Morisseau, Christophe; Zhou, Chunwei; Sun, Tianqi; Zhuang, Junning; Chen, Lu; Xu, Cheng; Liu, Zhongbo; Hammock, Bruce D; Chen, Guoliang