日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.

直接抑制 RAS 揭示了由 RAS G12 和 Q61 突变驱动的致癌信号的特征

Marasco Michelangelo, Kumar Dinesh, Garcia Borrego Santiago, Seale Tessa, Maddalena Giulia, Mezzadra Riccardo, Belanger Kylie, Cole Soren, Perez Brayan, Luan Wei, Mukherjee Radha, Aricescu Ilinca, Markov Vladimir, Zhu Yuxin, Arena Sabrina, Bardelli Alberto, de Stanchina Elisa, Lowe Scott W, Burkhart Richard A, Zimmerman Jacquelyn W, Yaeger Rona, Kopetz Scott E, Rosen Neal, Misale Sandra

Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet

磷酸肽与酪氨酸磷酸酶SHP2的N-SH2结构域的结合与其中心β折叠的解旋相关。

Marasco, Michelangelo; Kirkpatrick, John; Carlomagno, Teresa; Hub, Jochen S; Anselmi, Massimiliano

Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains

实验指导的分子模拟定义了PTPN11串联SH2结构域的异质结构集合。

Marasco, Michelangelo; Kirkpatrick, John; Carlomagno, Teresa; Hub, Jochen S; Anselmi, Massimiliano

Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network

磷酸酪氨酸通过动态变构网络将肽结合和SHP2激活偶联起来

Marasco, Michelangelo; Kirkpatrick, John; Nanna, Vittoria; Sikorska, Justyna; Carlomagno, Teresa

Specificity and regulation of phosphotyrosine signaling through SH2 domains

SH2结构域介导的磷酸酪氨酸信号传导的特异性和调控

Marasco, Michelangelo; Carlomagno, Teresa

(1)H, (13)C, (15)N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs

SHP2 SH2结构域与PD-1免疫酪氨酸基序复合物的(1)H、(13)C、(15)N化学位移分配

Marasco, Michelangelo; Kirkpatrick, John P; Carlomagno, Teresa