Marc David相关文献与解析，生知库 | 链接生命科学的每一步

Breaking Î²-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.

破坏 FUS 朊病毒样结构域中的 β 折叠可以保持相分离和功能，但可以防止聚集和毒性。

doi:10.64898/2026.02.17.706410

Wake Noah, Alcalde Juan, Jutzi Daniel, Bajaj Anjali, Kour Sukhleen, Barai Mayur, Weng Shuo-Lin, Cummings Samara, Zheng Tongyin, Anderson Eric N, Wang Szu-Huan, Puterbaugh Ryan, Bosco Daryl A, Schuster Benjamin S, Mittal Jeetain, Pandey Udai Bhan, Ruepp Marc-David, Fawzi Nicolas L

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS

单细胞RNA测序揭示了FUS-ALS和TARDBP-ALS患者运动神经元中特有的早期线粒体功能障碍。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-59679-1

Christoph Schweingruber ，Jik Nijssen ，Jonas Mechtersheimer ，Stefan Reber ，Mélanie Lebœuf ，Niamh L O'Brien ，Irene Mei ，Erin Hedges ，Michaela Keuper ，Julio Aguila Benitez ，Vlad Radoi ，Martin Jastroch ，Marc-David Ruepp # ，Eva Hedlund #

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS

在肌萎缩侧索硬化症（ALS）中，一种具有降低的相分离潜能的胞质SFPQ亚型表达上调。

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.adt4814

Jacob Neeves，Marija Petrić Howe，Oliver J Ziff，Beth Callaghan，Daniel Jutzi，Koustav Pal，Theodoros I Roumeliotis，Jyoti Choudhary，Adrian M Isaacs，Frank Rigo，C Frank Bennett，Marc-David Ruepp，Rickie Patani

ALS

发表日期：2025

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Exploration of Fully-Automated Body Composition Analysis Using Routine CT-Staging of Lung Cancer Patients for Survival Prognosis

利用肺癌患者常规CT分期进行全自动体成分分析以预测生存预后的研究

期刊:Journal of Cachexia Sarcopenia and Muscle

影响因子:9.1

doi:10.1002/jcsm.70021

Künnemann, Marc-David; Römer, Christian; Helfen, Anne; Bleckmann, Annalen; Kemper, Marcel; Heindel, Walter; Brix, Tobias J; Forsting, Michael; Haubold, Johannes; Opitz, Marcel; Schuler, Martin; Nensa, Felix; Borys, Katarzyna; Hosch, René

Correction: Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients

更正：对黑色素瘤患者进行预后总生存期分层的全容积体成分分析

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-025-06633-w

Borys, Katarzyna; Lodde, Georg; Livingstone, Elisabeth; Weishaupt, Carsten; Römer, Christian; Künnemann, Marc-David; Helfen, Anne; Zimmer, Lisa; Galetzka, Wolfgang; Haubold, Johannes; Friedrich, Christoph M; Umutlu, Lale; Heindel, Walter; Schadendorf, Dirk; Hosch, René; Nensa, Felix

黑色素瘤

发表日期：2025

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Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients

利用全容积体成分分析对黑色素瘤患者的预后总生存期进行分层

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-025-06507-1

黑色素瘤

发表日期：2025

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Thoracic MRI in Pediatric Oncology: Feasibility and Image Quality of Post-Contrast Free-Breathing Radial 3D T1 Weighted Imaging

胸部MRI在儿科肿瘤中的应用：增强后自由呼吸径向3D T1加权成像的可行性和图像质量

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines13092302

Tischendorf, Patricia; Künnemann, Marc-David; Krähling, Tobias; Lange, Jan Hendrik; Heindel, Walter; Beck, Laura

Analysing the effect of full-length and C-terminally truncated progranulin on proliferation, colony formation, and migration in HepG2 and U87 cells

分析全长和C端截短的颗粒蛋白前体对HepG2和U87细胞增殖、克隆形成和迁移的影响

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-025-26703-9.

Alexander M Hofer ,Luisa Tobler ,Marc-David Ruepp ,Oliver Mühlemann

上皮细胞

发表日期：2025

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Management of patients with posterior urethral valves "from the fetus to adolescence": French national diagnostic and care protocol (NDCP)

从胎儿期到青春期，对后尿道瓣膜患者的管理：法国国家诊断和护理方案（NDCP）

期刊:Orphanet Journal of Rare Diseases

影响因子:3.5

doi:10.1186/s13023-025-03712-5

El-Ghoneimi, Alaa; Harper, Luke; Pierucci, Ugo Maria; Blanc, Thomas; Rosenblatt, Jonathan; Sananes, Nicolas; Dreux, Sophie; Alison, Marianne; Avni, Fred; Decremer, Stéphane; Baudouin, Veronique; Oguchi, Sayaka; Baruch, Dan; Rolland-Santan, Pascale; Nadafi-Stoeffel, Hedyeh; Bonnet, Cécile; Paye-Jaouen, Annabel; Raffet, Eliane; Natio, Lise; Desprez, Berengere; Demede, Delphine; Leclair, Marc David; Peycelon, Matthieu

发表日期：2025

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Incarcerated geriatric patients' experiences of aging and healthcare

被监禁的老年患者的衰老和医疗保健经历

Breaking Î²-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.

破坏 FUS 朊病毒样结构域中的 β 折叠可以保持相分离和功能，但可以防止聚集和毒性。

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS

单细胞RNA测序揭示了FUS-ALS和TARDBP-ALS患者运动神经元中特有的早期线粒体功能障碍。

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS

在肌萎缩侧索硬化症（ALS）中，一种具有降低的相分离潜能的胞质SFPQ亚型表达上调。

Exploration of Fully-Automated Body Composition Analysis Using Routine CT-Staging of Lung Cancer Patients for Survival Prognosis

利用肺癌患者常规CT分期进行全自动体成分分析以预测生存预后的研究

Correction: Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients

更正：对黑色素瘤患者进行预后总生存期分层的全容积体成分分析

Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients

利用全容积体成分分析对黑色素瘤患者的预后总生存期进行分层

Thoracic MRI in Pediatric Oncology: Feasibility and Image Quality of Post-Contrast Free-Breathing Radial 3D T1 Weighted Imaging

胸部MRI在儿科肿瘤中的应用：增强后自由呼吸径向3D T1加权成像的可行性和图像质量

Analysing the effect of full-length and C-terminally truncated progranulin on proliferation, colony formation, and migration in HepG2 and U87 cells

分析全长和C端截短的颗粒蛋白前体对HepG2和U87细胞增殖、克隆形成和迁移的影响

Management of patients with posterior urethral valves "from the fetus to adolescence": French national diagnostic and care protocol (NDCP)

从胎儿期到青春期，对后尿道瓣膜患者的管理：法国国家诊断和护理方案（NDCP）