日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

变构泛 TEAD 抑制剂阻断致癌 YAP/TAZ 信号传导并克服 KRAS G12C 抑制剂耐药性

Thijs J Hagenbeek #, Jason R Zbieg #, Marc Hafner #, Rana Mroue, Jennifer A Lacap, Nicole M Sodir, Cameron L Noland, Shervin Afghani, Ayush Kishore, Kamakoti P Bhat, Xiaosai Yao, Stephen Schmidt, Saundra Clausen, Micah Steffek, Wendy Lee, Paul Beroza, Scott Martin, Eva Lin, Rina Fong, Paola Di Lello

Proteomic profiling across breast cancer cell lines and models

乳腺癌细胞系和模型的蛋白质组学分析

Marian Kalocsay, Matthew J Berberich, Robert A Everley, Maulik K Nariya, Mirra Chung, Benjamin Gaudio, Chiara Victor, Gary A Bradshaw, Robyn J Eisert, Marc Hafner, Peter K Sorger, Caitlin E Mills, Kartik Subramanian

Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action

激动剂和拮抗剂成纤维细胞生长因子受体 1 MAb 的系统药理学分析揭示了相似的独特作用方式

Jocelyn Chan, Joyce Chan, Lily Shao, Scott S Stawicki, Victoria C Pham, Rob W Akita, Marc Hafner, Lisa Crocker, Kebing Yu, James T Koerber, Gabriele Schaefer, Laetitia Comps-Agrar

RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

RTK依赖性诱导突变PI3Kα降解驱动GDC-0077(Inavolisib)疗效

Kyung W Song,Kyle A Edgar,Emily J Hanan,Marc Hafner,Jason Oeh,Mark Merchant,Deepak Sampath,Michelle A Nannini,Rebecca Hong,Lilian Phu,William F Forrest,Eric Stawiski,Stephen Schmidt,Nicholas Endres,Jane Guan,Jeffrey J Wallin,Jonathan Cheong,Emile G Plise,Gail D Lewis Phillips,Laurent Salphati,Timothy P Heffron,Alan G Olivero,Shiva Malek,Steven T Staben,Donald S Kirkpatrick,Anwesha Dey,Lori S Friedman

Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop

使用染料滴对活细胞和固定细胞进行多重且可重复的高内涵筛选

Caitlin E Mills #, Kartik Subramanian #, Marc Hafner #, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J Nirmal, Nicholas Clark, Peter K Sorger

EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

EHMT2甲基转移酶调控肺部细胞特性,是KRAS G12D肿瘤发生和扩散所必需的。

Ariel Pribluda ,Anneleen Daemen ,Anthony Nelson Lima ,Xi Wang ,Marc Hafner ,Chungkee Poon ,Zora Modrusan ,Anand Kumar Katakam ,Oded Foreman ,Jefferey Eastham ,Jefferey Hung ,Benjamin Haley ,Julia T Garcia ,Erica L Jackson ,Melissa R Junttila

Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility

治疗性配体通过削弱雌激素受体的移动性来拮抗雌激素受体的功能

Jane Guan, Wei Zhou, Marc Hafner, Robert A Blake, Cecile Chalouni, Irene P Chen, Tom De Bruyn, Jennifer M Giltnane, Steven J Hartman, Amy Heidersbach, Rene Houtman, Ellen Ingalla, Lorn Kategaya, Tracy Kleinheinz, Jun Li, Scott E Martin, Zora Modrusan, Michelle Nannini, Jason Oeh, Savita Ubhayakar, X

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

哺乳动物细胞系药物反应试验可重复性的多中心研究

Mario Niepel, Marc Hafner, Caitlin E Mills, Kartik Subramanian, Elizabeth H Williams, Mirra Chung, Benjamin Gaudio, Anne Marie Barrette, Alan D Stern, Bin Hu, James E Korkola; LINCS Consortium; Joe W Gray, Marc R Birtwistle, Laura M Heiser, Peter K Sorger

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

多组学分析确定了 FDA 批准的 CDK4/6 抑制剂的多药理学以及差异化临床活性的潜力

Marc Hafner, Caitlin E Mills, Kartik Subramanian, Chen Chen, Mirra Chung, Sarah A Boswell, Robert A Everley, Changchang Liu, Charlotte S Walmsley, Dejan Juric, Peter K Sorger

Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries

用于分析和设计优化小分子集合和库的化学信息学工具

Nienke Moret, Nicholas A Clark, Marc Hafner, Yuan Wang, Eugen Lounkine, Mario Medvedovic, Jinhua Wang, Nathanael Gray, Jeremy Jenkins, Peter K Sorger