日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

琥珀酸的积累通过琥珀酰化介导的线粒体叶酸循环调控抑制嘌呤的从头合成。

Mushtaq A Nengroo ,Austin T Klein ,Heather S Carr ,Olivia Vidal-Cruchez ,Umakant Sahu ,Daniel J McGrail ,Nidhi Sahni ,Niklas B Thompson ,Peter A Faull ,Peng Gao ,John M Asara ,Hardik Shah ,Marc L Mendillo ,Issam Ben-Sahra

Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life

严格调控对哺乳动物生命至关重要的核 HAPSTR1-HUWE1 通路

David R Amici, Sammy Alhayek, Austin T Klein, Yi-Zhi Wang, Anika P Wilen, Weimin Song, Pei Zhu, Abhishek Thakkar, McKenzi A King, Adam Wt Steffeck, Milad J Alasady, Clara Peek, Jeffrey N Savas, Marc L Mendillo

The HAPSTR2 retrogene buffers stress signaling and resilience in mammals

HAPSTR2 逆转录基因可缓冲哺乳动物的压力信号和恢复力

David R Amici, Harun Cingoz, Milad J Alasady, Sammy Alhayek, Claire M Phoumyvong, Nidhi Sahni, S Stephen Yi, Marc L Mendillo

PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition

PRMT 阻断可诱导有缺陷的 DNA 复制应激反应并与 PARP 抑制产生协同作用

Yang Li, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Travis D Kerr, Deepa Bisht, Yalong Wang, Sharad Awasthi, Babita Kaundal, Siqi Wu, Weiyi Peng, Marc L Mendillo, Yiling Lu, Collene R Jeter, Guang Peng, Jinsong Liu, Shannon N Westin, Anil K Sood, Michael T Lewis, Jishnu Das, S Stephen Yi, M

Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins

广泛的 BRCA1/2 独立同源重组缺陷是由 RNA 结合蛋白的改变引起的

Daniel J McGrail, Yang Li, Roger S Smith, Bin Feng, Hui Dai, Limei Hu, Briana Dennehey, Sharad Awasthi, Marc L Mendillo, Anil K Sood, Gordon B Mills, Shiaw-Yih Lin, S Stephen Yi, Nidhi Sahni

The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

mTORC1-SLC4A7 轴刺激碳酸氢盐输入,增强从头核苷酸合成

Eunus S Ali, Anna Lipońska, Brendan P O'Hara, David R Amici, Michael D Torno, Peng Gao, John M Asara, Mee-Ngan F Yap, Marc L Mendillo, Issam Ben-Sahra

HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state

HSF2 与 HSF1 协同驱动恶性状态所必需的转录程序

Roger S Smith, Seesha R Takagishi, David R Amici, Kyle Metz, Sitaram Gayatri, Milad J Alasady, Yaqi Wu, Sonia Brockway, Stephanie L Taiberg, Natalia Khalatyan, Mikko Taipale, Sandro Santagata, Luke Whitesell, Susan Lindquist, Jeffrey N Savas, Marc L Mendillo

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer

协同抑制PIM激酶和蛋白酶体作为治疗MYC过表达三阴性乳腺癌的策略

Ratika Kunder,Michelle Velyunskiy,Sara F Dunne,Byoung-Kyu Cho,Deepak Kanojia,Lauren Begg,Adrienne M Orriols,Erica Fleming-Trujillo,Pranathi Vadlamani,Alesia Vialichka,Rosemary Bolin,Jessica N Perrino,Diane Roth,Matthew R Clutter,Nicolette A Zielinski-Mozny,Young Ah Goo,Massimo Cristofanilli,Marc L Mendillo,Athanassios Vassilopoulos,Dai Horiuchi

Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq

使用 QMAP-Seq 对哺乳动物细胞进行定量和多重化学遗传表型分析

Sonia Brockway, Geng Wang, Jasen M Jackson, David R Amici, Seesha R Takagishi, Matthew R Clutter, Elizabeth T Bartom, Marc L Mendillo

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

对 220 例 CTCL 进行基因组分析,发现 RLTPR (p.Q575E) 中存在一种新的复发性功能获得改变

Joonhee Park, Jingyi Yang, Alexander T Wenzel, Akshaya Ramachandran, Wung J Lee, Jay C Daniels, Juhyun Kim, Estela Martinez-Escala, Nduka Amankulor, Barbara Pro, Joan Guitart, Marc L Mendillo, Jeffrey N Savas, Titus J Boggon, Jaehyuk Choi