日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual targeting of CD155/ TIGIT and PD-L1/ PD-1 immune checkpoints potentiates NK cell-mediated cytotoxicity in medulloblastoma

双重靶向 CD155/TIGIT 和 PD-L1/PD-1 免疫检查点可增强髓母细胞瘤中 NK 细胞介导的细胞毒性

Matthijs Monnikhof ,Michael Y Schakelaar ,Chris Meulenbroeks ,Matthias Quist ,Alicia Perzolli ,Aimee Selten ,Celeste J M Koster ,Daniëlle S C Maassen ,Alba Montoro Canelo ,Maureen Fredriks ,Myrthe J A Koppers ,Kim Clevers ,Julia Klein ,Vela Kaludjerovic ,Jan Meeldijk ,Emma W Pijnappel ,Heggert G Rebel ,Sven van Kempen ,Sandra Crnko ,Thijs Koorman ,Aniello Federico ,Francesco Valzano ,Pieter Wesseling ,Friso G J Calkoen ,Jasper van der Lugt ,Toine Ten Broeke ,Marcel Kool ,Niels Bovenschen

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

视黄酸和 BH3 类似物在 MYC(N) 驱动的胚胎神经系统肿瘤中的协同作用

Till Seiboldt, Constantia Zeiser, Duy Nguyen, Simay Celikyürekli, Sonja Herter, Sara Najafi, Alexandra Stroh-Dege, Chris Meulenbroeks, Norman Mack, Rabia Salem-Altintas, Frank Westermann, Matthias Schlesner, Till Milde, Marcel Kool, Tim Holland-Letz, Meike Vogler, Heike Peterziel, Olaf Witt, Ina Oeh

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma

全基因组 CRISPR-Cas9 敲除筛选确定 DNMT1 是音猬因子髓母细胞瘤中可用药的依赖性

Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A Segal, Ghazaleh Tabatabai, Daniel J Merk

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

三维基因组图谱分析揭示室管膜瘤亚组特异性染色体构象和肿瘤依赖性基因

Konstantin Okonechnikov #,Aylin Camgöz #,Owen Chapman,Sameena Wani,Donglim Esther Park,Jens-Martin Hübner,Abhijit Chakraborty,Meghana Pagadala,Rosalind Bump,Sahaana Chandran,Katerina Kraft,Rocio Acuna-Hidalgo,Derek Reid,Kristin Sikkink,Monika Mauermann,Edwin F Juarez,Anne Jenseit,James T Robinson,Kristian W Pajtler,Till Milde,Natalie Jäger,Petra Fiesel,Ling Morgan,Sunita Sridhar,Nicole G Coufal,Michael Levy,Denise Malicki,Charlotte Hobbs,Stephen Kingsmore,Shareef Nahas,Matija Snuderl,John Crawford,Robert J Wechsler-Reya,Tom Belle Davidson,Jennifer Cotter,George Michaiel,Gudrun Fleischhack,Stefan Mundlos,Anthony Schmitt,Hannah Carter,Kulandaimanuvel Antony Michealraj,Sachin A Kumar,Michael D Taylor,Jeremy Rich,Frank Buchholz,Jill P Mesirov,Stefan M Pfister,Ferhat Ay,Jesse R Dixon,Marcel Kool,Lukas Chavez

Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability

磷酸酶 CTDNEP1 的缺失会引发 MYC 扩增和基因组不稳定性,从而增强髓母细胞瘤的侵袭性

Zaili Luo #, Dazhuan Xin #, Yunfei Liao #, Kalen Berry, Sean Ogurek, Feng Zhang, Liguo Zhang, Chuntao Zhao, Rohit Rao, Xinran Dong, Hao Li, Jianzhong Yu, Yifeng Lin, Guoying Huang, Lingli Xu, Mei Xin, Ryuichi Nishinakamura, Jiyang Yu, Marcel Kool, Stefan M Pfister, Martine F Roussel, Wenhao Zhou, Wi

Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics

复发性非典型畸胎瘤样/横纹肌样瘤 (AT/RT) 在组织学、表观遗传学、拷贝数分析和转录组学上表现出离散的进展特征

Pascal D Johann #, Lea Altendorf #, Emma-Maria Efremova, Till Holsten, Mona Steinbügl, Karolina Nemes, Alicia Eckhardt, Catena Kresbach, Michael Bockmayr, Arend Koch, Christine Haberler, Manila Antonelli, John DeSisto, Martin U Schuhmann, Peter Hauser, Reiner Siebert, Susanne Bens, Marcel Kool, Adam

Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments

患者来源和异种移植来源的类器官能够重现儿童脑肿瘤的特征和患者治疗效果。

Chiara Lago ,Aniello Federico ,Gloria Leva ,Norman L Mack ,Benjamin Schwalm ,Claudio Ballabio ,Matteo Gianesello ,Luana Abballe ,Isabella Giovannoni ,Sofia Reddel ,Sabrina Rossi ,Nicolas Leone ,Andrea Carai ,Angela Mastronuzzi ,Alessandra Bisio ,Alessia Soldano ,Concetta Quintarelli ,Franco Locatelli ,Marcel Kool ,Evelina Miele ,Luca Tiberi

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

非典型畸胎瘤样/横纹肌样肿瘤样肿瘤揭示了亚组特异性的药物脆弱性

Irene Paassen, Justin Williams, Carla Ríos Arceo, Femke Ringnalda, Kimberly Shea Mercer, Juliane L Buhl, Natalia Moreno, Aniello Federico, Niels E Franke, Mariette Kranendonk, Santhosh A Upadhyaya, Kornelius Kerl, Marc van de Wetering, Hans Clevers, Marcel Kool, Eelco W Hoving, Martine F Roussel, Ja

Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D

使用 mLSR-3D 对完整健康和肿瘤组织进行多光谱共聚焦 3D 成像

Ravian L van Ineveld #, Raphaël Collot #, Mario Barrera Román, Anna Pagliaro, Nils Bessler, Hendrikus C R Ariese, Michiel Kleinnijenhuis, Marcel Kool, Maria Alieva, Susana M Chuva de Sousa Lopes, Ellen J Wehrens, Anne C Rios

Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors

初级纤毛有助于非典型畸胎瘤样/横纹肌瘤的侵袭性

Lena Blümel, Nan Qin, Johannes Berlandi, Eunice Paisana, Rita Cascão, Carlos Custódia, David Pauck, Daniel Picard, Maike Langini, Kai Stühler, Frauke-Dorothee Meyer, Sarah Göbbels, Bastian Malzkorn, Max C Liebau, João T Barata, Astrid Jeibmann, Kornelius Kerl, Serap Erkek, Marcel Kool, Stefan M Pfis