日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease

全基因组相互作用研究结合体重指数发现,CYP7A1 和 GIPR 是代谢功能障碍相关脂肪肝疾病的遗传调节因子。

Jamialahmadi, Oveis; Mujica, Endrina; Morris, Lowri; Mancina, Rosellina Margherita; Ciociola, Ester; Qadri, Sami F; Maurotti, Samantha; Malvestiti, Francesco; Li-Gao, Ruifang; Ronzoni, Luisa; Tavaglione, Federica; Maude, Hannah; Allalou, Amin; Emmanouilidou, Anastasia; Vespasiani-Gentilucci, Umberto; Rosendaal, Frits Richard; Yki-Järvinen, Hannele; Cebola, Inês; Valenti, Luca; Hoed, Marcel den; Romeo, Stefano

APOBEC3B protein expression associates with poor prognosis for breast cancer patients with ER-positive disease

APOBEC3B蛋白表达与ER阳性乳腺癌患者预后不良相关

Schreurs, Maartje A C; Timmermans, A Mieke; Carpenter, Michael A; Smid, Marcel; den Bakker, Michael A; van Deurzen, Carolien H M; Harris, Reuben S; Martens, John W M

A nanowell platform to identify, sort and expand high antibody-producing cells

用于识别、分类和扩增高抗体产生细胞的纳米孔平台

Fikri Abali, Richard Schasfoort, Sanne Nijland, Jelle Wittenberns, Arjan G J Tibbe, Marcel den Hartog, Louis Boon, Leon W M M Terstappen

A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes

功能基因组框架阐明新的非酒精性脂肪肝致病基因

Peter Saliba-Gustafsson, Johanne M Justesen, Amanda Ranta, Disha Sharma, Ewa Bielczyk-Maczynska, Jiehan Li, Laeya A Najmi, Maider Apodaka, Patricia Aspichueta, Hanna M Björck, Per Eriksson, Anders Franco-Cereceda, Mike Gloudemans, Endrina Mujica, Marcel den Hoed, Themistocles L Assimes, Thomas Quert

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

胰岛β细胞中RREB1的缺失会降低细胞内胰岛素含量并影响内分泌细胞基因表达。

Katia K Mattis,Nicole A J Krentz,Christoph Metzendorf,Fernando Abaitua,Aliya F Spigelman,Han Sun,Jennifer M Ikle,Swaraj Thaman,Antje K Rottner,Austin Bautista,Eugenia Mazzaferro,Marta Perez-Alcantara,Jocelyn E Manning Fox,Jason M Torres,Agata Wesolowska-Andersen,Grace Z Yu,Anubha Mahajan,Anders Larsson,Patrick E MacDonald,Benjamin Davies,Marcel den Hoed,Anna L Gloyn

Predictive Genetic Biomarkers for the Development of Peritoneal Metastases in Colorectal Cancer

预测结直肠癌腹膜转移发展的遗传生物标志物

Danique J I Heuvelings, Anne G W E Wintjens, Laura Moonen, Sanne M E Engelen, Ignace H J T de Hingh, Liselot B Valkenburg-van Iersel, Marcel den Dulk, Jan Beckervordersandforth, Sharon G M Thijssen, Daphne J G Leunissen, Laurents P S Stassen, Daniel Keszthelyi, Zlatan Mujagic, Ernst-Jan M Speel, Nic

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

全基因组关联分析揭示了身体活动和久坐行为在疾病预防中的潜在机制和作用,从而为理解这些因素提供了新的视角。

Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S; Bartz, Traci M; Bentley, Amy R; Bielak, Lawrence F; Chong, Mike; Chu, Audrey Y; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M; Haller, Toomas; Hartwig, Fernando P; Hillis, David A; Huikari, Ville; Heard-Costa, Nancy; Holzapfel, Christina; Jackson, Anne U; Johansson, Åsa; Jørgensen, Anja Moltke; Kaakinen, Marika A; Karlsson, Robert; Kerr, Kathleen F; Kim, Boram; Koolhaas, Chantal M; Kutalik, Zoltan; Lagou, Vasiliki; Lind, Penelope A; Lorentzon, Mattias; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Metzendorf, Christoph; Monroe, Kristine R; Pacolet, Alexander; Pérusse, Louis; Pool, Rene; Richmond, Rebecca C; Rivera, Natalia V; Robiou-du-Pont, Sebastien; Schraut, Katharina E; Schulz, Christina-Alexandra; Stringham, Heather M; Tanaka, Toshiko; Teumer, Alexander; Turman, Constance; van der Most, Peter J; Vanmunster, Mathias; van Rooij, Frank J A; van Vliet-Ostaptchouk, Jana V; Zhang, Xiaoshuai; Zhao, Jing-Hua; Zhao, Wei; Balkhiyarova, Zhanna; Balslev-Harder, Marie N; Baumeister, Sebastian E; Beilby, John; Blangero, John; Boomsma, Dorret I; Brage, Soren; Braund, Peter S; Brody, Jennifer A; Bruinenberg, Marcel; Ekelund, Ulf; Liu, Ching-Ti; Cole, John W; Collins, Francis S; Cupples, L Adrienne; Esko, Tõnu; Enroth, Stefan; Faul, Jessica D; Fernandez-Rhodes, Lindsay; Fohner, Alison E; Franco, Oscar H; Galesloot, Tessel E; Gordon, Scott D; Grarup, Niels; Hartman, Catharina A; Heiss, Gerardo; Hui, Jennie; Illig, Thomas; Jago, Russell; James, Alan; Joshi, Peter K; Jung, Taeyeong; Kähönen, Mika; Kilpeläinen, Tuomas O; Koh, Woon-Puay; Kolcic, Ivana; Kraft, Peter P; Kuusisto, Johanna; Launer, Lenore J; Li, Aihua; Linneberg, Allan; Luan, Jian'an; Vidal, Pedro Marques; Medland, Sarah E; Milaneschi, Yuri; Moscati, Arden; Musk, Bill; Nelson, Christopher P; Nolte, Ilja M; Pedersen, Nancy L; Peters, Annette; Peyser, Patricia A; Power, Christine; Raitakari, Olli T; Reedik, Mägi; Reiner, Alex P; Ridker, Paul M; Rudan, Igor; Ryan, Kathy; Sarzynski, Mark A; Scott, Laura J; Scott, Robert A; Sidney, Stephen; Siggeirsdottir, Kristin; Smith, Albert V; Smith, Jennifer A; Sonestedt, Emily; Strøm, Marin; Tai, E Shyong; Teo, Koon K; Thorand, Barbara; Tönjes, Anke; Tremblay, Angelo; Uitterlinden, Andre G; Vangipurapu, Jagadish; van Schoor, Natasja; Völker, Uwe; Willemsen, Gonneke; Williams, Kayleen; Wong, Quenna; Xu, Huichun; Young, Kristin L; Yuan, Jian Min; Zillikens, M Carola; Zonderman, Alan B; Ameur, Adam; Bandinelli, Stefania; Bis, Joshua C; Boehnke, Michael; Bouchard, Claude; Chasman, Daniel I; Smith, George Davey; de Geus, Eco J C; Deldicque, Louise; Dörr, Marcus; Evans, Michele K; Ferrucci, Luigi; Fornage, Myriam; Fox, Caroline; Garland, Theodore Jr; Gudnason, Vilmundur; Gyllensten, Ulf; Hansen, Torben; Hayward, Caroline; Horta, Bernardo L; Hyppönen, Elina; Jarvelin, Marjo-Riitta; Johnson, W Craig; Kardia, Sharon L R; Kiemeney, Lambertus A; Laakso, Markku; Langenberg, Claudia; Lehtimäki, Terho; Marchand, Loic Le; Magnusson, Patrik K E; Martin, Nicholas G; Melbye, Mads; Metspalu, Andres; Meyre, David; North, Kari E; Ohlsson, Claes; Oldehinkel, Albertine J; Orho-Melander, Marju; Pare, Guillaume; Park, Taesung; Pedersen, Oluf; Penninx, Brenda W J H; Pers, Tune H; Polasek, Ozren; Prokopenko, Inga; Rotimi, Charles N; Samani, Nilesh J; Sim, Xueling; Snieder, Harold; Sørensen, Thorkild I A; Spector, Tim D; Timpson, Nicholas J; van Dam, Rob M; van der Velde, Nathalie; van Duijn, Cornelia M; Vollenweider, Peter; Völzke, Henry; Voortman, Trudy; Waeber, Gérard; Wareham, Nicholas J; Weir, David R; Wichmann, Heinz-Erich; Wilson, James F; Hevener, Andrea L; Krook, Anna; Zierath, Juleen R; Thomis, Martine A I; Loos, Ruth J F; Hoed, Marcel den

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

CRISPR-Cas9 在体内靶位点和非靶位点诱导产生大的结构变异,这些变异会跨代遗传。

Ida Höijer,Anastasia Emmanouilidou,Rebecka Östlund,Robin van Schendel,Selma Bozorgpana,Marcel Tijsterman,Lars Feuk,Ulf Gyllensten,Marcel den Hoed #,Adam Ameur #

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

烟曲霉色氨酸代谢途径对宿主免疫的影响各不相同。

Teresa Zelante ,Tsokyi Choera ,Anne Beauvais ,Francesca Fallarino ,Giuseppe Paolicelli ,Giuseppe Pieraccini ,Marco Pieroni ,Claudia Galosi ,Claudia Beato ,Antonella De Luca ,Francesca Boscaro ,Riccardo Romoli ,Xin Liu ,Adilia Warris ,Paul E Verweij ,Eloise Ballard ,Monica Borghi ,Marilena Pariano ,Gabriele Costantino ,Mario Calvitti ,Carmine Vacca ,Vasilis Oikonomou ,Marco Gargaro ,Alicia Yoke Wei Wong ,Louis Boon ,Marcel den Hartog ,Zdeněk Spáčil ,Paolo Puccetti ,Jean-Paul Latgè ,Nancy P Keller ,Luigina Romani

Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

无扩增长读测序揭示了不可预见的 CRISPR-Cas9 脱靶活性

Ida Höijer, Josefin Johansson, Sanna Gudmundsson, Chen-Shan Chin, Ignas Bunikis, Susana Häggqvist, Anastasia Emmanouilidou, Maria Wilbe, Marcel den Hoed, Marie-Louise Bondeson, Lars Feuk, Ulf Gyllensten, Adam Ameur