日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.

针对极高危髓母细胞瘤中非同源末端连接与放射治疗之间的合成致死性进行靶向治疗

DeCarlo Alexandria, MacLeod Graham, Fernandes da Silva Carolina, Shen Li Qing, Povilaikaite Julija, Deane Madeline, Aragao Lucas, Sie Mariska, Termini Deborah, Magee Jonathan, Gudenas Brian, Sukumaran Sneha, Charron Frederic, Marcellus Richard, Al-Awar Rima, Aman Ahmed, Reynaud Denis, Trolat Amarine, Wybenga-Groot Leanne, Tabori Uri, Nör Carolina, Harding Shane M, Moran Michael F, Northcott Paul A, Dirks Peter, Angers Stephane, Ramaswamy Vijay

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

PRMT1 抑制剂 MS023 抑制 RNA 剪接,使小细胞肺癌对 DNA 损伤剂更加敏感

Aparnathi Mansi K, Ul Haq Sami, St-Germain Jonathan, Nixon Kevin C J, Walton Joseph, Song Lifang, Majeed Safa, Patel Parasvi S, Subramaniam Ratheesh, Philip Vivek, Marcellus Richard, Barsyte-Lovejoy Dalia, Al-Awar Rima, Hakem Razqallah, Arrowsmith Cheryl H, Ailles Laurie, Raught Brian, Lok Benjamin H

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Kimani Serah W, Noureldin Mahmoud, Wilson Brian, Hoffer Laurent, Green Stuart R, Szewczyk Magdalena M, González-Álvarez Héctor, Mohammed Mohammed, Chan Manuel, Krausser Chiara, Li Alice Shi Ming, Hajian Taraneh, Tucker Sarah, Joshi Dhananjay, Saraon Punit, Thériault Brigitte, Kim Ji Sup, Santhakumar Vijayaratnam, Loppnau Peter, Li Yanjun, Seitova Almagul, Dong Aiping, Kiyota Taira, Hammann Tobias, Gehrtz Paul, Patel Bhashant, Rathod Vaibhavi, Vala Anand, Rout Bhimsen, Jagodra Paras, Brown Peter J, Aman Ahmed, Ramnauth Jailall, Poda Gennady, Uehling David, Arrowsmith Cheryl H, Barsyte-Lovejoy Dalia, Marcellus Richard, Ackloo Suzanne, Mamai Ahmed, Al-Awar Rima, Halabelian Levon

A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC/TYR subgroup atypical teratoid rhabdoid tumors.

激酶组药物筛选发现多 TKI 协同作用和 ERBB2 信号传导是 MYC/TYR 亚组非典型畸胎瘤样横纹肌瘤的治疗弱点

Golbourn Brian, Ho Ben, Bondoc Andrew, Luck Amanda, Fan Xiaolian, Richardson Elizabeth, Marcellus Richard, Prakesch Michael, Halbert Mathew, Agrawal Nishant, Smith Christian, Huang Annie, Rutka James T

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

OICR12694 的发现:一种新型、高效、选择性强且口服生物利用度高的 BCL6 BTB 抑制剂

Mamai, Ahmed; Chau, Anh M; Wilson, Brian J; Watson, Iain D; Joseph, Babu B; Subramanian, Pandiaraju R; Morshed, Monzur M; Morin, Justin A; Prakesch, Michael A; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A; Pomroy, Neil C; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E; Al-Awar, Rima; Privé, Gilbert G; Isaac, Methvin B

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

谱系定义的平滑肌肉瘤亚型在诊断前数年就已出现,并决定患者的生存期。

Anderson, Nathaniel D; Babichev, Yael; Fuligni, Fabio; Comitani, Federico; Layeghifard, Mehdi; Venier, Rosemarie E; Dentro, Stefan C; Maheshwari, Anant; Guram, Sheena; Wunker, Claire; Thompson, J Drew; Yuki, Kyoko E; Hou, Huayun; Zatzman, Matthew; Light, Nicholas; Bernardini, Marcus Q; Wunder, Jay S; Andrulis, Irene L; Ferguson, Peter; Razak, Albiruni R Abdul; Swallow, Carol J; Dowling, James J; Al-Awar, Rima S; Marcellus, Richard; Rouzbahman, Marjan; Gerstung, Moritz; Durocher, Daniel; Alexandrov, Ludmil B; Dickson, Brendan C; Gladdy, Rebecca A; Shlien, Adam

Identical Hik-Rre systems are involved in perception and transduction of salt signals and hyperosmotic signals but regulate the expression of individual genes to different extents in Synechocystis

在聚球藻中,相同的 Hik-Rre 系统参与盐信号和高渗信号的感知和转导,但对单个基因表达的调控程度不同。

Esposito, Francesco; Pierantoni, Giovanna Maria; Battista, Sabrina; Melillo, Rosa Marina; Scala, Stefania; Chieffi, Paolo; Fedele, Monica; Fusco, Alfredo; Agrawal, Pooja; Chen, Yu-Ting; Schilling, Birgit; Gibson, Bradford W; Hughes, Robert E; Ryu, Myung-Jeom; Liu, Yangang; Zhong, Xiaofen; Du, Juan; Peterson, Nicholas; Kong, Guangyao; Li, Hongda; Wang, Jinyong; Salamat, Shahriar; Chang, Qiang; Zhang, Jing; Yang, Cuixia; Cao, Manlin; Liu, Hua; He, Yiqing; Xu, Jing; Du, Yan; Liu, Yiwen; Wang, Wenjuan; Cui, Lian; Hu, Jiajie; Gao, Feng; Bagheri-Yarmand, Rozita; Vadlamudi, Ratna K; Kumar, Rakesh; Alves da Costa, Cristine; Dunys, Julie; Brau, Frédéric; Wilk, Sherwin; Cappai, Roberto; Checler, Frédéric; Bansal, Abhisheka; Singh, Shailja; More, Kunal R; Hans, Dhiraj; Nangalia, Kuldeep; Yogavel, Manickam; Sharma, Amit; Chitnis, Chetan E; Quy, Pham Nguyen; Kuma, Akiko; Pierre, Philippe; Mizushima, Noboru; Sarig, Rachel; Zaltsman, Yehudit; Marcellus, Richard C; Flavell, Richard; Mak, Tak W; Gross, Atan; Wang, Hong; Bell, Ming; Sreenivasan, Urmila; Hu, Hong; Liu, Jun; Dalen, Knut; Londos, Constantine; Yamaguchi, Tomohiro; Rizzo, Mark A; Coleman, Rosalind; Gong, Dawei; Brasaemle, Dawn; Sztalryd, Carole; Eisele, Petra S; Salatino, Silvia; Sobek, Jens; Hottiger, Michael O; Handschin, Christoph; Yao, Shaohua; Qian, Meilin; Deng, Senyi; Xie, Lifang; Yang, Hanshuo; Xiao, Chun; Zhang, Ting; Xu, Hong; Zhao, Xia; Wei, Yu-quan; Mo, Xianming; Happonen, Kaisa E; Melin Fürst, Camilla; Saxne, Tore; Heinegård, Dick; Blom, Anna M; Paithoonrangsarid, Kalyanee; Shumskaya, Maria A; Kanesaki, Yu; Satoh, Syusei; Tabata, Satoshi; Los, Dmitry A; Zinchenko, Vladislav V; Hayashi, Hidenori; Tanticharoen, Morakot; Suzuki, Iwane; Murata, Norio; Shumskaya, Maria A; Paithoonrangsarid, Kalyanee; Kanesaki, Yu; Los, Dmitry A; Zinchenko, Vladislav V; Tanticharoen, Morakot; Suzuki, Iwane; Murata, Norio

Ca(V)1.3 channels and intracellular calcium mediate osmotic stress-induced N-terminal c-Jun kinase activation and disruption of tight junctions in Caco-2 cell monolayers

Ca(V)1.3通道和细胞内钙介导渗透压应激诱导的N端c-Jun激酶激活和Caco-2细胞单层紧密连接的破坏

Thoh, Maikho; Kumar, Pankaj; Nagarajaram, Hampathalu A; Manna, Sunil K; Ohlig, Stefanie; Pickhinke, Ute; Sirko, Svetlana; Bandari, Shyam; Hoffmann, Daniel; Dreier, Rita; Farshi, Pershang; Götz, Magdalena; Grobe, Kay; Sarig, Rachel; Zaltsman, Yehudit; Marcellus, Richard C; Flavell, Richard; Mak, Tak W; Gross, Atan; Perwitasari, Olivia; Cho, Hyelim; Diamond, Michael S; Gale, Michael Jr; Busillo, John M; Azzam, Kathleen M; Cidlowski, John A; Samak, Geetha; Narayanan, Damodaran; Jaggar, Jonathan H; Rao, RadhaKrishna

The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors

小分子GMX1778是NAD+生物合成的强效抑制剂:增强烟酸磷酸核糖转移酶1缺陷型肿瘤治疗的策略

Watson, Mark; Roulston, Anne; Bélec, Laurent; Billot, Xavier; Marcellus, Richard; Bédard, Dominique; Bernier, Cynthia; Branchaud, Stéphane; Chan, Helen; Dairi, Kenza; Gilbert, Karine; Goulet, Daniel; Gratton, Michel-Olivier; Isakau, Henady; Jang, Anne; Khadir, Abdelkrim; Koch, Elizabeth; Lavoie, Manon; Lawless, Michael; Nguyen, Mai; Paquette, Denis; Turcotte, Emilie; Berger, Alvin; Mitchell, Matthew; Shore, Gordon C; Beauparlant, Pierre