日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

吲哚基序对于 N5 取代的 paullones 的抗锥虫活性至关重要

Irina Ihnatenko, Marco J Müller, Oliver C F Orban, Jens C Lindhof, Diego Benítez, Cecilia Ortíz, Estefanía Dibello, Leonardo L Seidl, Marcelo A Comini, Conrad Kunick

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

通过高通量筛选鉴定具有抗锥硫酮合成酶活性的类药物分子

Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A Comini

Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

通过高通量筛选发现新型利什曼原虫锥虫硫酮合成酶抑制剂

Trong-Nhat Phan, Kyuho Paul Park, Diego Benítez, Marcelo A Comini, David Shum, Joo Hwan No

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system

慢性恰加斯心脏病患者的克氏锥虫重组抗体可识别哺乳动物的神经系统

Leticia L Niborski, Mariana Potenza, Renato G S Chirivi, Leandro Simonetti, Micaela S Ossowski, Vanina Grippo, Maria May, Daniela I Staquicini, Adriana Parodi-Talice, Carlos Robello, Marcelo A Comini, Guillermo D Alonso, Jos M H Raats, Karina A Gómez

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi

锥虫硫酮合成酶赋予克氏锥虫生长、生存优势和对抗原虫药物的抵抗力

Andrea C Mesías, Natalia Sasoni, Diego G Arias, Cecilia Pérez Brandán, Oliver C F Orban, Conrad Kunick, Carlos Robello, Marcelo A Comini, Nisha J Garg, M Paola Zago

Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites

动力学研究揭示了氧化还原活性谷氧还蛋白在锥虫寄生虫硫醇氧化还原代谢进化中的关键作用

Bruno Manta, Matías N Möller, Mariana Bonilla, Matías Deambrosi, Karin Grunberg, Massimo Bellanda, Marcelo A Comini, Gerardo Ferrer-Sueta

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region

锥虫中单硫醇谷氧还蛋白 1 的谱系特异性、内在无序的 N 端延伸含有一个调控区

Mattia Sturlese, Bruno Manta, Andrea Bertarello, Mariana Bonilla, Moreno Lelli, Barbara Zambelli, Karin Grunberg, Stefano Mammi, Marcelo A Comini, Massimo Bellanda0

Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity

布氏锥虫线粒体单硫醇谷胱甘肽-1 与铁硫簇的结合:铁硫簇协调的分子基础及其与寄生虫感染的相关性

Bruno Manta, Carlo Pavan, Mattia Sturlese, Andrea Medeiros, Martina Crispo, Carsten Berndt, R Luise Krauth-Siegel, Massimo Bellanda, Marcelo A Comini