日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small molecule allosterically activates SecA dependent secretion

一种小分子通过变构作用激活SecA依赖性分泌

Sedky, Haitham; Hamed, Mohamed Belal; Krishnamurthy, Srinath; Chaltin, Patrick; Marchand, Arnaud; Pericolle, Vincent; Versele, Matthias; Karamanou, Spyridoula; Economou, Anastassios

A coronavirus assembly inhibitor that targets the viral membrane protein.

一种针对病毒膜蛋白的冠状病毒组装抑制剂

Laporte Manon, Jochmans Dirk, Bardiot Dorothée, Desmarets Lowiese, Debski-Antoniak Oliver J, Mizzon Giulia, Abdelnabi Rana, Leyssen Pieter, Chiu Winston, Zhang Zhikuan, Nomura Norimichi, Boland Sandro, Ohto Umeharu, Stahl Yannick, Wuyts Jurgen, De Jonghe Steven, Stevaert Annelies, van Hemert Martijn J, Bontes Brenda W, Wanningen Patrick, Groenewold G J Mirjam, Zegar Aneta, Owczarek Katarzyna, Joshi Sanjata, Koukni Mohamed, Arzel Philippe, Klaassen Hugo, Vanherck Jean-Christophe, Vandecaetsbeek Ilse, Cremers Niels, Donckers Kim, Francken Thibault, Van Buyten Tina, Rymenants Jasper, Schepers Joost, Pyrc Krzysztof, Hilgenfeld Rolf, Dubuisson Jean, Bosch Berend-Jan, Van Kuppeveld Frank, Eydoux Cecilia, Decroly Etienne, Canard Bruno, Naesens Lieve, Weynand Birgit, Snijder Eric J, Belouzard Sandrine, Shimizu Toshiyuki, Bartenschlager Ralf, Hurdiss Daniel L, Marchand Arnaud, Chaltin Patrick, Neyts Johan

Synthetic GPR84 Agonists in Colorectal Cancer: Effective in THP-1 Cells but Ineffective in BMDMs and MC38 Mouse Tumor Models.

合成 GPR84 激动剂在结直肠癌中:对 THP-1 细胞有效,但对 BMDM 和 MC38 小鼠肿瘤模型无效

Schwarzfischer Marlene, Walker Maria Rae, Curcio Michele, Boshta Nader M, Marchand Arnaud, Soons Erik, Pöhlmann Doris, Wawrzyniak Marcin, Morsy Yasser, Lang Silvia, Spalinger Marianne Rebecca, Versele Matthias, Scharl Michael

A Robust Phenotypic High-Throughput Antiviral Assay for the Discovery of Rabies Virus Inhibitors

一种用于发现狂犬病毒抑制剂的稳健表型高通量抗病毒检测方法

Wang, Xinyu; Chiu, Winston; Klaassen, Hugo; Marchand, Arnaud; Chaltin, Patrick; Neyts, Johan; Jochmans, Dirk

The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut

肠道上皮细胞顶膜上的β2-肾上腺素能受体感知糖类,从而刺激肠道对葡萄糖的吸收。

Paulussen, Frederik; Kulkarni, Chetan P; Stolz, Frank; Lescrinier, Eveline; De Graeve, Stijn; Lambin, Suzan; Marchand, Arnaud; Chaltin, Patrick; In't Veld, Peter; Mebis, Joseph; Tavernier, Jan; Van Dijck, Patrick; Luyten, Walter; Thevelein, Johan M

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

ALG-097111 是一种强效且选择性的 SARS-CoV-2 3-胰凝乳蛋白酶样半胱氨酸蛋白酶抑制剂,在叙利亚仓鼠模型中显示出体内疗效。

Vandyck, Koen; Abdelnabi, Rana; Gupta, Kusum; Jochmans, Dirk; Jekle, Andreas; Deval, Jerome; Misner, Dinah; Bardiot, Dorothée; Foo, Caroline S; Liu, Cheng; Ren, Suping; Beigelman, Leonid; Blatt, Lawrence M; Boland, Sandro; Vangeel, Laura; Dejonghe, Steven; Chaltin, Patrick; Marchand, Arnaud; Serebryany, Vladimir; Stoycheva, Antitsa; Chanda, Sushmita; Symons, Julian A; Raboisson, Pierre; Neyts, Johan

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

一类新型的基孔肯雅病毒小分子抑制剂,靶向病毒加帽机制

Abdelnabi, Rana; Kovacikova, Kristina; Moesslacher, Julia; Donckers, Kim; Battisti, Verena; Leyssen, Pieter; Langer, Thierry; Puerstinger, Gerhard; Quérat, Gilles; Li, Changqing; Decroly, Etienne; Tas, Ali; Marchand, Arnaud; Chaltin, Patrick; Coutard, Bruno; van Hemert, Martijn; Neyts, Johan; Delang, Leen

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium

呼吸道合胞病毒(RSV)抑制剂在人呼吸道上皮细胞中的差异性抗病毒活性

Mirabelli, Carmen; Jaspers, Martine; Boon, Mieke; Jorissen, Mark; Koukni, Mohamed; Bardiot, Dorothée; Chaltin, Patrick; Marchand, Arnaud; Neyts, Johan; Jochmans, Dirk

Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa

鉴定出一种新型抗菌化合物 1-((2,4-二氯苯乙基)氨基)-3-苯氧基丙-2-醇,该化合物对铜绿假单胞菌的持久菌具有活性。

Liebens, Veerle; Defraine, Valerie; Knapen, Wouter; Swings, Toon; Beullens, Serge; Corbau, Romu; Marchand, Arnaud; Chaltin, Patrick; Fauvart, Maarten; Michiels, Jan

Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus

合成策略及含二酰胺杂环化合物对登革热病毒和黄热病毒的抗病毒活性评价

Saudi, Milind; Zmurko, Joanna; Kaptein, Suzanne; Rozenski, Jef; Gadakh, Bharat; Chaltin, Patrick; Marchand, Arnaud; Neyts, Johan; Van Aerschot, Arthur