日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

PTPN2/PTPN1抑制剂ABBV-CLS-484可释放强大的抗肿瘤免疫力。

Christina K Baumgartner # ,Hakimeh Ebrahimi-Nik # ,Arvin Iracheta-Vellve ,Keith M Hamel ,Kira E Olander ,Thomas G R Davis ,Kathleen A McGuire ,Geoff T Halvorsen ,Omar I Avila ,Chirag H Patel ,Sarah Y Kim ,Ashwin V Kammula ,Audrey J Muscato ,Kyle Halliwill ,Prasanthi Geda ,Kelly L Klinge ,Zhaoming Xiong ,Ryan Duggan ,Liang Mu ,Mitchell D Yeary ,James C Patti ,Tyler M Balon ,Rebecca Mathew ,Carey Backus ,Domenick E Kennedy ,Angeline Chen ,Kenton Longenecker ,Joseph T Klahn ,Cara L Hrusch ,Navasona Krishnan ,Charles W Hutchins ,Jax P Dunning ,Marinka Bulic ,Payal Tiwari ,Kayla J Colvin ,Cun Lan Chuong ,Ian C Kohnle ,Matthew G Rees ,Andrew Boghossian ,Melissa Ronan ,Jennifer A Roth ,Meng-Ju Wu ,Juliette S M T Suermondt ,Nelson H Knudsen ,Collins K Cheruiyot ,Debattama R Sen ,Gabriel K Griffin ,Todd R Golub ,Nabeel El-Bardeesy ,Joshua H Decker ,Yi Yang ,Magali Guffroy ,Stacey Fossey ,Patricia Trusk ,Im-Meng Sun ,Yue Liu ,Wei Qiu ,Qi Sun ,Marcia N Paddock ,Elliot P Farney ,Mark A Matulenko ,Clay Beauregard ,Jennifer M Frost # ,Kathleen B Yates # ,Philip R Kym # ,Robert T Manguso #

Epinephrine inhibits PI3Kα via the Hippo kinases

肾上腺素通过 Hippo 激酶抑制 PI3Kα

Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A Kesicki, Edward R Kastenhuber, Thorsten Wiederhold, Tomer M Yaron, Emily M Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N Paddock, Guoan Zhang, Benjamin D Hopki

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

INPP4B肿瘤抑制因子调节EGFR转运并促进三阴性乳腺癌的发生发展

Hui Liu ,Marcia N Paddock ,Haibin Wang ,Charles J Murphy ,Renee C Geck ,Adrija J Navarro ,Gerburg M Wulf ,Olivier Elemento ,Volker Haucke ,Lewis C Cantley ,Alex Toker

Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

利用共价抑制剂靶向PI5P4K脂质激酶家族治疗癌症

Sindhu Carmen Sivakumaren ,Hyeseok Shim ,Tinghu Zhang ,Fleur M Ferguson ,Mark R Lundquist ,Christopher M Browne ,Hyuk-Soo Seo ,Marcia N Paddock ,Theresa D Manz ,Baishan Jiang ,Ming-Feng Hao ,Pranav Krishnan ,Diana G Wang ,T Jonathan Yang ,Nicholas P Kwiatkowski ,Scott B Ficarro ,James M Cunningham ,Jarrod A Marto ,Sirano Dhe-Paganon ,Lewis C Cantley ,Nathanael S Gray

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism

PIP4Ks通过一种不依赖于催化作用的机制抑制胰岛素信号传导。

Diana G Wang ,Marcia N Paddock ,Mark R Lundquist ,Janet Y Sun ,Oksana Mashadova ,Solomon Amadiume ,Timothy W Bumpus ,Cindy Hodakoski ,Benjamin D Hopkins ,Matthew Fine ,Amanda Hill ,T Jonathan Yang ,Jeremy M Baskin ,Lukas E Dow ,Lewis C Cantley

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

线粒体一碳途径支持癌细胞胞浆叶酸的完整性

Yuxiang Zheng, Ting-Yu Lin, Gina Lee, Marcia N Paddock, Jessica Momb, Zhe Cheng, Qian Li, Dennis L Fei, Benjamin D Stein, Shivan Ramsamooj, Guoan Zhang, John Blenis, Lewis C Cantley

The BRCT domain of PARP-1 is required for immunoglobulin gene conversion

PARP-1 的 BRCT 结构域是免疫球蛋白基因转换所必需的

Marcia N Paddock, Ben D Buelow, Shunichi Takeda, Andrew M Scharenberg