日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

单核 RNA 测序整合风险变异共定位,发现 17 种细胞类型特异性腹部肥胖基因,与代谢功能障碍相关的脂肪肝疾病有关

Seung Hyuk T Lee, Kristina M Garske, Uma Thanigai Arasu, Asha Kar, Zong Miao, Marcus Alvarez, Amogha Koka, Nicholas Darci-Maher, Jihane N Benhammou, David Z Pan, Tiit Örd, Dorota Kaminska, Ville Männistö, Sini Heinonen, Martin Wabitsch, Markku Laakso, Vatche G Agopian, Joseph R Pisegna, Kirsi H Piet

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

跨组织组学分析发现十个脂肪基因编码肥胖相关非酒精性脂肪肝疾病中的分泌蛋白

Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T Lee, David Z Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N Benhammou, Martin Wabitsch, Joseph R Pisegna, Ville Männistö, Kirsi H Pietiläinen, Markku Laakso, Janet S Sinsheimer, Minna U

Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism

受损的脂肪细胞 SLC7A10 促进脂质储存,与胰岛素抵抗和改变的 BCAA 代谢有关

Regine Å Jersin, Divya Sri Priyanka Tallapragada, Linn Skartveit, Mona S Bjune, Maheswary Muniandy, Sindre Lee-Ødegård, Sini Heinonen, Marcus Alvarez, Kåre Inge Birkeland, Christian André Drevon, Päivi Pajukanta, Adrian McCann, Kirsi H Pietiläinen, Melina Claussnitzer, Gunnar Mellgren, Simon N Danke

Isolation of Nuclei from Human Snap-frozen Liver Tissue for Single-nucleus RNA Sequencing

从人类速冻肝组织中分离细胞核用于单核 RNA 测序

Marcus Alvarez, Jihane N Benhammou, Shuyun Rao, Lopa Mishra, Joseph R Pisegna, Päivi Pajukanta

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells

对脂肪-肌肉组织中肥胖-运动轴的单细胞解析表明间充质干细胞发挥着关键作用

Jiekun Yang ,Maria Vamvini ,Pasquale Nigro ,Li-Lun Ho ,Kyriakitsa Galani ,Marcus Alvarez ,Yosuke Tanigawa ,Ashley Renfro ,Nicholas P Carbone ,Markku Laakso ,Leandro Z Agudelo ,Päivi Pajukanta ,Michael F Hirshman ,Roeland J W Middelbeek ,Kevin Grove ,Laurie J Goodyear ,Manolis Kellis

Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival

人类肝脏单核和单细胞 RNA 测序确定影响生存的肝细胞癌相关细胞类型

Marcus Alvarez #, Jihane N Benhammou #, Nicholas Darci-Maher, Samuel W French, Steven B Han, Janet S Sinsheimer, Vatche G Agopian, Joseph R Pisegna, Päivi Pajukanta1

Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

获得性肥胖背后的分子途径:同卵双胞胎中 BMI 不一致的脂肪组织和骨骼肌多组学

Birgitta W van der Kolk, Sina Saari, Alen Lovric, Muhammad Arif, Marcus Alvarez, Arthur Ko, Zong Miao, Navid Sahebekhtiari, Maheswary Muniandy, Sini Heinonen, Ali Oghabian, Riikka Jokinen, Sakari Jukarainen, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Taru Tukiainen, Nina Lundbo

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

鉴定 TBX15 为腹部肥胖基因的脂肪主反式调节剂

David Z Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S Sinsheimer, Karen L Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria Teresa Tusié-Luna, Carlos Aguilar-Salinas, Kirsi

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

RIPK1基因变异与人类肥胖相关,可通过治疗手段沉默该基因以减轻小鼠肥胖。

Denuja Karunakaran ,Adam W Turner ,Anne-Claire Duchez ,Sebastien Soubeyrand ,Adil Rasheed ,David Smyth ,David P Cook ,Majid Nikpay ,Joshua W Kandiah ,Calvin Pan ,Michele Geoffrion ,Richard Lee ,Ludovic Boytard ,Hailey Wyatt ,My-Anh Nguyen ,Paulina Lau ,Markku Laakso ,Bhama Ramkhelawon ,Marcus Alvarez ,Kirsi H Pietiläinen ,Päivi Pajukanta ,Barbara C Vanderhyden ,Peter Liu ,Scott B Berger ,Peter J Gough ,John Bertin ,Mary-Ellen Harper ,Aldons J Lusis ,Ruth McPherson ,Katey J Rayner

Enhancing droplet-based single-nucleus RNA-seq resolution using the semi-supervised machine learning classifier DIEM

使用半监督机器学习分类器 DIEM 增强基于液滴的单核 RNA 测序分辨率

Marcus Alvarez #, Elior Rahmani #, Brandon Jew, Kristina M Garske, Zong Miao, Jihane N Benhammou, Chun Jimmie Ye, Joseph R Pisegna, Kirsi H Pietiläinen, Eran Halperin, Päivi Pajukanta