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Dynamic conformations of the P. furiosus MR-DNA complex link Mre11 nuclease activity to DNA-stimulated Rad50 ATP hydrolysis

嗜热古菌MR-DNA复合物的动态构象将Mre11核酸酶活性与DNA刺激的Rad50 ATP水解联系起来

期刊:Communications Biology

影响因子:5.2

doi:10.1038/s42003-025-08003-0.

Marella D Canny # ,Mahtab Beikzadeh # ,Navneet Kaur ,Rohan Pendse ,Michael P Latham

Three segment ligation of a 104 kDa multi-domain protein by SrtA and OaAEP1

SrtA 和 OaAEP1 对 104 kDa 多结构域蛋白进行三片段连接

期刊:Journal of Biomolecular NMR

影响因子:2.4

doi:10.1007/s10858-022-00409-w

Stephan B Azatian ,Marella D Canny ,Michael P Latham

发表日期：2023

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LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

基于LRET的HADDOCK结构模型描述了Mre11-Rad50 DNA损伤修复复合物切割DNA所需的构象异质性。

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.69579

Canny, Marella D; Latham, Michael P

Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms

古细菌Rad50 ABC ATPase D环中的相邻突变通过不同的机制破坏ATP水解的变构调节。

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkz1228.

Zachary K Boswell ,Marella D Canny ,Tanner A Buschmann ,Julie Sang ,Michael P Latham

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex

MRE11-RAD50-NBS1复合物中已报道的疾病相关突变调查

期刊:Cells

影响因子:5.2

doi:10.3390/cells9071678

Rahman, Samiur; Canny, Marella D; Buschmann, Tanner A; Latham, Michael P

RAD50

发表日期：2020

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Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions

保守的Mre11残基突变改变蛋白质动力学，从而分离核酸酶功能

期刊:Journal of Molecular Biology

影响因子:4.7

doi:10.1016/j.jmb.2020.03.030.

Samiur Rahman ,Mahtab Beikzadeh ,Marella D Canny ,Navneet Kaur ,Michael P Latham

MRE11

发表日期：2020

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Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

抑制 53BP1 有利于同源性依赖的 DNA 修复并提高 CRISPR-Cas9 基因组编辑效率

期刊:Nature Biotechnology

影响因子:33.1

doi:10.1038/nbt.4021

Marella D Canny, Nathalie Moatti, Leo C K Wan, Amélie Fradet-Turcotte, Danielle Krasner, Pedro A Mateos-Gomez, Michal Zimmermann, Alexandre Orthwein, Yu-Chi Juang, Wei Zhang, Sylvie M Noordermeer, Eduardo Seclen, Marcus D Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Timothy F Ng, Tiffany Ch

信号转导

发表日期：2018

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A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

Rad50 ABC ATPase 在 DNA 修复中发挥功能，其基础是动态变构通路。

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-018-19908-8.

Zachary K Boswell ,Samiur Rahman ,Marella D Canny ,Michael P Latham

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

RNF168 同源物 RNF169 定义了一类新型泛素化组蛋白阅读器，参与对 DNA 损伤的反应

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.23872

Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay

表观遗传

发表日期：2017

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DNA Modulates Structural Transitions and Oligomerization Kinetics of the Functional Amyloid CRES

DNA调控功能性淀粉样蛋白CRES的结构转变和寡聚化动力学

Dynamic conformations of the P. furiosus MR-DNA complex link Mre11 nuclease activity to DNA-stimulated Rad50 ATP hydrolysis

嗜热古菌MR-DNA复合物的动态构象将Mre11核酸酶活性与DNA刺激的Rad50 ATP水解联系起来

Three segment ligation of a 104 kDa multi-domain protein by SrtA and OaAEP1

SrtA 和 OaAEP1 对 104 kDa 多结构域蛋白进行三片段连接

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

基于LRET的HADDOCK结构模型描述了Mre11-Rad50 DNA损伤修复复合物切割DNA所需的构象异质性。

Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms

古细菌Rad50 ABC ATPase D环中的相邻突变通过不同的机制破坏ATP水解的变构调节。

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex

MRE11-RAD50-NBS1复合物中已报道的疾病相关突变调查

Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions

保守的Mre11残基突变改变蛋白质动力学，从而分离核酸酶功能

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

抑制 53BP1 有利于同源性依赖的 DNA 修复并提高 CRISPR-Cas9 基因组编辑效率

A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

Rad50 ABC ATPase 在 DNA 修复中发挥功能，其基础是动态变构通路。

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

RNF168 同源物 RNF169 定义了一类新型泛素化组蛋白阅读器，参与对 DNA 损伤的反应