Margison相关文献与解析，生知库 | 链接生命科学的每一步

Keskin, Fourat; Noone, Hannah; Dickman, Mark J; Allen, Esther; Mulcrone, William D; Rasmussen, Lars Holm; Bruun Hansen, Hans Christian; O'Connor, Peter J; Povey, Andrew C; Margison, Geoffrey P; Williams, David M

肿瘤

肿瘤免疫

发表日期：2025

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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

对 370 种潜在的 MGMT 失活剂进行 QSAR 和化学交叉分析，以确定影响失活效力的结构特征

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics15082170

Sun, Guohui; Bai, Peiying; Fan, Tengjiao; Zhao, Lijiao; Zhong, Rugang; McElhinney, R Stanley; McMurry, T Brian H; Donnelly, Dorothy J; McCormick, Joan E; Kelly, Jane; Margison, Geoffrey P

MGMT

发表日期：2023

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The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions

DNA烷基转移酶家族的DNA修复蛋白：共同机制，多样化功能

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms25010463

Tessmer, Ingrid; Margison, Geoffrey P

发表日期：2023

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Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

胆碱代谢是蠕虫感染中巨噬细胞IL-4极化和RELMα上调的基础。

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1011658

Ghorbani, Peyman; Kim, Sang Yong; Smith, Tyler K T; Minarrieta, Lucía; Robert-Gostlin, Victoria; Kilgour, Marisa K; Ilijevska, Maja; Alecu, Irina; Snider, Shayne A; Margison, Kaitlyn D; Nunes, Julia R C; Woo, Daniel; Pember, Ciara; O'Dwyer, Conor; Ouellette, Julie; Kotchetkov, Pavel; St-Pierre, Julie; Bennett, Steffany A L; Lacoste, Baptiste; Blais, Alexandre; Nair, Meera G; Fullerton, Morgan D

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O(6)-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O(6)-Alkylguanine Adductome

重组O(6)-甲基鸟嘌呤-DNA甲基转移酶活性位点胰蛋白酶肽段与人结直肠DNA孵育后的质谱分析揭示了O(6)-烷基鸟嘌呤加合物的存在。

期刊:Chemical Research in Toxicology

影响因子:3.8

doi:10.1021/acs.chemrestox.3c00207

Abdelhady, Rasha; Senthong, Pattama; Eyers, Claire E; Reamtong, Onrapak; Cowley, Elizabeth; Cannizzaro, Luca; Stimpson, Joanna; Cain, Kathleen; Wilkinson, Oliver J; Williams, Nicholas H; Barran, Perdita E; Margison, Geoffrey P; Williams, David M; Povey, Andrew C

Human

发表日期：2023

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Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity

脂肪酸诱导的脂毒性和肥胖会抑制肝脏胆碱转运

期刊:Hepatology Communications

影响因子:4.6

doi:10.1002/hep4.1516

O'Dwyer, Conor; Yaworski, Rebecca; Katsumura, Sakie; Ghorbani, Peyman; Gobeil Odai, Kaelan; Nunes, Julia R C; LeBlond, Nicholas D; Sanjana, Sabrin; Smith, Tyler T K; Han, Shauna; Margison, Kaitlyn D; Alain, Tommy; Morita, Masahiro; Fullerton, Morgan D

O(6)-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function

O(6)-甲基鸟嘌呤诱导的转录突变会降低p53肿瘤抑制功能。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1721764115

Ezerskyte, Monika; Paredes, João A; Malvezzi, Stefano; Burns, John A; Margison, Geoffrey P; Olsson, Magnus; Scicchitano, David A; Dreij, Kristian

Choline transport links macrophage phospholipid metabolism and inflammation

胆碱运输连接巨噬细胞磷脂代谢和炎症

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.RA118.003180

Shayne A Snider, Kaitlyn D Margison, Peyman Ghorbani, Nicholas D LeBlond, Conor O'Dwyer, Julia R C Nunes, Thao Nguyen, Hongbin Xu, Steffany A L Bennett, Morgan D Fullerton

The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation

与人类高甘油三酯血症相关的载脂蛋白C-III（Gln38Lys）变异体是一种功能获得性突变。

期刊:Journal of Lipid Research

影响因子:4.1

doi:10.1194/jlr.M077313

Sundaram, Meenakshi; Curtis, Kaitlin R; Amir Alipour, Mohsen; LeBlond, Nicholas D; Margison, Kaitlyn D; Yaworski, Rebecca A; Parks, Robin J; McIntyre, Adam D; Hegele, Robert A; Fullerton, Morgan D; Yao, Zemin

发表日期：2017

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IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

IGF-1R 抑制可诱导人类黑色素瘤对替莫唑胺的时间表依赖性敏感

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.5631

Roger Ramcharan, Tamara Aleksic, Wilfride Petnga Kamdoum, Shan Gao, Sophia X Pfister, Jordan Tanner, Esther Bridges, Ruth Asher, Amanda J Watson, Geoffrey P Margison, Mick Woodcock, Emmanouela Repapi, Ji-Liang Li, Mark R Middleton, Valentine M Macaulay

Bracken Fern Carcinogen, Ptaquiloside, Forms a Guanine O(6)-Adduct in DNA

蕨类植物致癌物蕨苷（Ptaquiloside）在DNA中形成鸟嘌呤O(6)加合物。

QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

对 370 种潜在的 MGMT 失活剂进行 QSAR 和化学交叉分析，以确定影响失活效力的结构特征

The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions

DNA烷基转移酶家族的DNA修复蛋白：共同机制，多样化功能

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

胆碱代谢是蠕虫感染中巨噬细胞IL-4极化和RELMα上调的基础。

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O(6)-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O(6)-Alkylguanine Adductome

重组O(6)-甲基鸟嘌呤-DNA甲基转移酶活性位点胰蛋白酶肽段与人结直肠DNA孵育后的质谱分析揭示了O(6)-烷基鸟嘌呤加合物的存在。

Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity

脂肪酸诱导的脂毒性和肥胖会抑制肝脏胆碱转运

O(6)-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function

O(6)-甲基鸟嘌呤诱导的转录突变会降低p53肿瘤抑制功能。

Choline transport links macrophage phospholipid metabolism and inflammation

胆碱运输连接巨噬细胞磷脂代谢和炎症

The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation

与人类高甘油三酯血症相关的载脂蛋白C-III（Gln38Lys）变异体是一种功能获得性突变。

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

IGF-1R 抑制可诱导人类黑色素瘤对替莫唑胺的时间表依赖性敏感