Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA
一项针对健康、未感染过疟疾的成年人的临床试验，旨在评估 MuStDO5（一种包含五个基因的恶性疟原虫孢子/肝期 DNA 疫苗，并联合递增剂量的人 GM-CSF DNA）的安全性、耐受性、免疫原性和有效性。
期刊:Human Vaccines & Immunotherapeutics
影响因子:3.5
doi:10.4161/hv.22129
Richie, Thomas L; Charoenvit, Yupin; Wang, Ruobing; Epstein, Judith E; Hedstrom, Richard C; Kumar, Sanjai; Luke, Thomas C; Freilich, Daniel A; Aguiar, Joao C; Sacci, John B Jr; Sedegah, Martha; Nosek, Ronald A Jr; De La Vega, Patricia; Berzins, Mara P; Majam, Victoria F; Abot, Esteban N; Ganeshan, Harini; Richie, Nancy O; Banania, Jo Glenna; Baraceros, Maria Fe B; Geter, Tanya G; Mere, Robin; Bebris, Lolita; Limbach, Keith; Hickey, Bradley W; Lanar, David E; Ng, Jennifer; Shi, Meng; Hobart, Peter M; Norman, Jon A; Soisson, Lorraine A; Hollingdale, Michael R; Rogers, William O; Doolan, Denise L; Hoffman, Stephen L
疟疾
炎症/感染
微生物学
M-CSF
GM-CSF
免疫/内分泌
