Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines
受体酪氨酸激酶依赖性 PI3K 激活是 KRAS 突变人类结直肠癌细胞系中 EGFR/RAS/MAPK 通路垂直抑制的逃避机制
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-019-1035-0
Pietro Paolo Vitiello, Claudia Cardone, Giulia Martini, Davide Ciardiello, Valentina Belli, Nunzia Matrone, Giusi Barra, Stefania Napolitano, Carmina Della Corte, Mimmo Turano, Maria Furia, Teresa Troiani, Floriana Morgillo, Ferdinando De Vita, Fortunato Ciardiello, Erika Martinelli
信号转导
肿瘤
肠癌
肿瘤细胞
MAPK/ERK
PI3K/Akt
Human
