日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer

53BP1作为PARP抑制剂治疗同源重组缺陷型卵巢癌疗效的潜在预测因子

Rachel M Hurley ,Andrea E Wahner Hendrickson ,Daniel W Visscher ,Peter Ansell ,Maria I Harrell ,Jill M Wagner ,Vivian Negron ,Krista M Goergen ,Matthew J Maurer ,Ann L Oberg ,X Wei Meng ,Karen S Flatten ,Maja J A De Jonge ,Carla D Van Herpen ,Jourik A Gietema ,Rutger H T Koornstra ,Agnes Jager ,Martha W den Hollander ,Matthew Dudley ,Stacie P Shepherd ,Elizabeth M Swisher ,Scott H Kaufmann

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

全基因组和高密度 CRISPR-Cas9 筛选可识别导致 PARP 抑制剂耐药性的 PARP1 点突变

Stephen J Pettitt, Dragomir B Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

所有 BRCA1 拷贝的甲基化可预测卵巢癌对 PARP 抑制剂 rucaparib 的反应

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I Harrell, Giada V Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

恢复 RAD51C 和 RAD51D 的继发性体细胞突变与高级别卵巢癌对 PARP 抑制剂 Rucaparib 的获得性耐药性有关

Olga Kondrashova, Minh Nguyen, Kristy Shield-Artin, Anna V Tinker, Nelson N H Teng, Maria I Harrell, Michael J Kuiper, Gwo-Yaw Ho, Holly Barker, Maria Jasin, Rohit Prakash, Elizabeth M Kass, Meghan R Sullivan, Gregory J Brunette, Kara A Bernstein, Robert L Coleman, Anne Floquet, Michael Friedlander,

RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance

RING 结构域缺陷的 BRCA1 促进 PARP 抑制剂和铂类耐药性

Yifan Wang, John J Krais, Andrea J Bernhardy, Emmanuelle Nicolas, Kathy Q Cai, Maria I Harrell, Hyoung H Kim, Erin George, Elizabeth M Swisher, Fiona Simpkins, Neil Johnson

Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

侵袭性骨髓增生性肿瘤中的聚(ADP-核糖)聚合酶抑制剂超敏反应

Keith W Pratz, Brian D Koh, Anand G Patel, Karen S Flatten, Weijie Poh, James G Herman, Robert Dilley, Maria I Harrell, B Douglas Smith, Judith E Karp, Elizabeth M Swisher, Michael A McDevitt, Scott H Kaufmann

Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis

肿瘤诱导的哨兵淋巴结淋巴管生成和淋巴液增加先于黑色素瘤转移

Maria I Harrell, Brian M Iritani, Alanna Ruddell