日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

发现具有优异药代动力学和物理化学性质的临床阶段选择性谷氨酰胺酶-1 (GLS-1) 抑制剂 IPN60090

Michael J Soth, Kang Le, Maria Emilia Di Francesco, Matthew M Hamilton, Gang Liu, Jason P Burke, Chris L Carroll, Jeffrey J Kovacs, Jennifer P Bardenhagen, Christopher A Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R Garvey, Jason P Gay, Mary K Geck Do, Jennifer Gre

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

前瞻性发现 E3 连接酶-底物相互作用的小分子增强剂

Kyle R Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E Basham, Chris Padovani, Yan Lou, Thomas J Cummins, Stephanie L Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A Gallop, Neil F Bence, Paul A Barsanti, Anjanabha Saha