日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization

人类IDR的生物分子凝聚通过染色体内环化或高密度启动子定位启动内源性转录

Jing Li,Shizhe Liu,Sunghwan Kim,Jacob Goell,Zachary Allen Drum,John Patrick Flores,Alex J Ma,Barun Mahata,Mario Escobar,Alex Raterink,Jeong Hyun Ahn,Erik R Terán,Rosa Selenia Guerra-Resendez,Yuhao Zhou,Bo Yu,Michael R Diehl,Gang Greg Wang,Anna-Karin Gustavsson,Douglas H Phanstiel,Isaac B Hilton

Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells

对具有不同甲基转移酶活性和基因沉默活性的基于 CRISPR/Cas9 的理性设计的 DNA 甲基转移酶在人类细胞系和原代人类 T 细胞中的表征

Rosa Selenia Guerra-Resendez ,Samantha LeGoff Lydon ,Alex J Ma ,Guy C Bedford ,Daniel R Reed ,Sunghwan Kim ,Erik R Terán ,Tomoki Nishiguchi ,Mario Escobar ,Andrew R DiNardo ,Isaac B Hilton

Oxidative stress promotes cytotoxicity in human cancer cell lines exposed to Escallonia spp. extracts

氧化应激促进暴露于埃斯卡洛尼亚属植物提取物的人类癌细胞系的细胞毒性

Jara-Gutiérrez, Carlos; Mercado, Luis; Paz-Araos, Marilyn; Howard, Carolyn; Parraga, Mario; Escobar, Camila; Mellado, Marco; Madrid, Alejandro; Montenegro, Iván; Santana, Paula; Murgas, Paola; Jimenez-Jara, Cristina; González-Olivares, Luis Guillermo; Ahumada, Manuel; Villena, Joan

Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased Cytotoxicity

定制基于 CRISPR/Cas 的表观基因组编辑器,实现可编程染色质酰化并降低细胞毒性

Jacob Goell, Jing Li, Barun Mahata, Alex J Ma, Sunghwan Kim, Spencer Shah, Shriya Shah, Maria Contreras, Suchir Misra, Daniel Reed, Guy C Bedford, Mario Escobar, Isaac B Hilton

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

紧凑型工程化人类机械敏感转录激活模块可实现高效且用途广泛的合成转录控制。

Barun Mahata ,Alan Cabrera ,Daniel A Brenner ,Rosa Selenia Guerra-Resendez ,Jing Li ,Jacob Goell ,Kaiyuan Wang ,Yannie Guo ,Mario Escobar ,Abinand Krishna Parthasarathy ,Hailey Szadowski ,Guy Bedford ,Daniel R Reed ,Sunghwan Kim ,Isaac B Hilton

Aortic Stenosis Phenotypes and Precision Transcatheter Aortic Valve Implantation

主动脉瓣狭窄表型与精准经导管主动脉瓣置换术

Khawaja, Muzamil; Virk, Hafeez Ul Hassan; Bandyopadhyay, Dhrubajyoti; Rodriguez, Mario; Escobar, Johao; Alam, Mahboob; Jneid, Hani; Krittanawong, Chayakrit

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions

基于 CRISPR 的转录激活因子的系统比较揭示了增强子-启动子相互作用的基因调控特征

Kaiyuan Wang, Mario Escobar, Jing Li, Barun Mahata, Jacob Goell, Spencer Shah, Madeleine Cluck, Isaac B Hilton

Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells

基因组编辑和转录控制能力的量化揭示了人类细胞中不同 CRISPR/Cas 系统之间的层次结构

Mario Escobar, Jing Li, Aditi Patel, Shizhe Liu, Qi Xu, Isaac B Hilton

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

利用基于 CRISPR/Cas9 的染色质激酶实现可编程的人类组蛋白磷酸化和基因激活

Jing Li,Barun Mahata,Mario Escobar,Jacob Goell,Kaiyuan Wang,Pranav Khemka,Isaac B Hilton

Glycogen metabolism in mink uterine epithelial cells and its regulation by estradiol, progesterone and insulin

水貂子宫上皮细胞糖原代谢及其受雌二醇、孕酮和胰岛素的调控

Ayokunle Hodonu ,Mario Escobar ,Logan Beach ,Jason Hunt ,Jack Rose