日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

利用 CRISPR 碱基编辑技术鉴定可提高胎儿血红蛋白表达的新型 HPFH 样突变

Nithin Sam Ravi ,Beeke Wienert ,Stacia K Wyman ,Henry William Bell ,Anila George ,Gokulnath Mahalingam ,Jonathan T Vu ,Kirti Prasad ,Bhanu Prasad Bandlamudi ,Nivedhitha Devaraju ,Vignesh Rajendiran ,Nazar Syedbasha ,Aswin Anand Pai ,Yukio Nakamura ,Ryo Kurita ,Muthuraman Narayanasamy ,Poonkuzhali Balasubramanian ,Saravanabhavan Thangavel ,Srujan Marepally ,Shaji R Velayudhan ,Alok Srivastava ,Mark A DeWitt ,Merlin Crossley ,Jacob E Corn ,Kumarasamypet M Mohankumar

High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation

在红细胞分化过程中,镰状突变的高水平校正在体内被放大

Wendy Magis, Mark A DeWitt, Stacia K Wyman, Jonathan T Vu, Seok-Jin Heo, Shirley J Shao, Finn Hennig, Zulema G Romero, Beatriz Campo-Fernandez, Suzanne Said, Matthew S McNeill, Garrett R Rettig, Yongming Sun, Yu Wang, Mark A Behlke, Donald B Kohn, Dario Boffelli, Mark C Walters, Jacob E Corn, David

Controlled Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells

可控的细胞周期和静止状态使得移植富集的成体造血干细胞和祖细胞能够高效进行同源重组修复(HDR)

Jiyung J Shin,Markus S Schröder,Francisco Caiado,Stacia K Wyman,Nicolas L Bray,Matteo Bordi,Mark A Dewitt,Jonathan T Vu,Won-Tae Kim,Dirk Hockemeyer,Markus G Manz,Jacob E Corn

ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin

ATF4 调节 MYB,以增加 γ-珠蛋白来应对 β-珠蛋白的损失

Mandy Y Boontanrart, Markus S Schröder, Gautier M Stehli, Marija Banović, Stacia K Wyman, Rachel J Lew, Matteo Bordi, Benjamin G Gowen, Mark A DeWitt, Jacob E Corn

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells

利用 CRISPR-Cas9 技术对人红细胞中假定的胎儿珠蛋白抑制因子进行检测

Jennifer E Chung,Wendy Magis,Jonathan Vu,Seok-Jin Heo,Kirmo Wartiovaara,Mark C Walters,Ryo Kurita,Yukio Nakamura,Dario Boffelli,David I K Martin,Jacob E Corn,Mark A DeWitt

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

纳米粒子递送 Cas9 核糖核蛋白和供体 DNA 体内诱导同源定向 DNA 修复

Kunwoo Lee, Michael Conboy, Hyo Min Park, Fuguo Jiang, Hyun Jin Kim, Mark A Dewitt, Vanessa A Mackley, Kevin Chang, Anirudh Rao, Colin Skinner, Tamanna Shobha, Melod Mehdipour, Hui Liu, Wen-Chin Huang, Freeman Lan, Nicolas L Bray, Song Li, Jacob E Corn, Kazunori Kataoka, Jennifer A Doudna, Irina Con