日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing

用于神经毒素效力测试应用的工程神经肌肉组织同步纵向分析的自动化平台

Jacob W Fleming, Molly C McCloskey, Kevin Gray, David R Nash, Vincent Leung, Christos Michas, Shawn M Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L Mack, Nicholas A Geisse, Alec S T Smith

Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFNγ Exposure

人类运动神经元在长期暴露于 IFNγ 后可引发 ALS 病理特征并揭示该疾病的潜在生物标志物

Changho Chun, Jung Hyun Lee, Mark Bothwell, Paul Nghiem, Alec S T Smith, David L Mack

HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D)

HDAC6 抑制可纠正人类干细胞型夏科-马里-图斯病 (2D 型) 模型中的电生理和轴突运输缺陷

Alec S T Smith, Jong Hyun Kim, Changho Chun, Ava Gharai, Hyo Won Moon, Eun Young Kim, Soo Hyun Nam, Nina Ha, Ju Young Song, Ki Wha Chung, Hyun Myung Doo, Jennifer Hesson, Julie Mathieu, Mark Bothwell, Byung-Ok Choi, Deok-Ho Kim

Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies

尽管存在转录组和剪接差异,人类诱导性多能干细胞衍生的 TDP-43 突变神经元在多个基因编辑系中表现出一致的功能表型

Alec S T Smith, Changho Chun, Jennifer Hesson, Julie Mathieu, Paul N Valdmanis, David L Mack, Byung-Ok Choi, Deok-Ho Kim, Mark Bothwell

Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling

细胞内 LINGO-1 负向调节 Trk 神经营养因子受体信号

James S Meabon, Rian de Laat, Katsuaki Ieguchi, Dmitry Serbzhinsky, Mark P Hudson, B Russel Huber, Jesse C Wiley, Mark Bothwell

LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments

LINGO-1 蛋白与细胞内膜区室中的 p75 神经营养因子受体相互作用

James S Meabon, Rian De Laat, Katsuaki Ieguchi, Jesse C Wiley, Mark P Hudson, Mark Bothwell

Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers

通过二硫键连接受体二聚体的构象重排激活 p75 神经营养因子受体

Marçal Vilar, Ioannis Charalampopoulos, Rajappa S Kenchappa, Anastasia Simi, Esra Karaca, Alessandra Reversi, Soyoung Choi, Mark Bothwell, Ismael Mingarro, Wilma J Friedman, Giampietro Schiavo, Philippe I H Bastiaens, Peter J Verveer, Bruce D Carter, Carlos F Ibáñez