日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release

一种靶向 Claudin 18.2 的亲和力调节型 T 细胞衔接器显示出强大的抗肿瘤活性,且细胞因子释放有限

Miguel Gaspar # ,Marina Natoli # ,Laure Castan ,Sharif Rahmy ,Martin Korade 3rd ,Cathryn Kelton ,Kathy Mulgrew ,Oisin Huhn ,D Gareth Rees ,Anna Sigurdardottir ,Christopher Lloyd ,Jonathan J Taylor ,Phillip M Brailey ,Laura Dallaway ,Aleksandra Toloczko ,Nicolas Giraldo ,Maria A S Broggi ,Andrew Kunihiro ,Sudhanshu Abhishek ,Yun He ,Yiping Rong ,Jim Eyles ,Kathryn Ball ,Jonathan Fitzgerald ,Scott A Hammond ,Saso Cemerski ,Simon J Dovedi ,Mark Cobbold

The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境增强癌症检查点免疫疗法的疗效。

Elizabeth L Hardaker # ,Emilio Sanseviero # ,Ankur Karmokar # ,Devon Taylor # ,Marta Milo ,Chrysis Michaloglou ,Adina Hughes ,Mimi Mai ,Matthew King ,Anisha Solanki ,Lukasz Magiera ,Ricardo Miragaia ,Gozde Kar ,Nathan Standifer ,Michael Surace ,Shaan Gill ,Alison Peter ,Sara Talbot ,Sehmus Tohumeken ,Henderson Fryer ,Ali Mostafa ,Kathy Mulgrew ,Carolyn Lam ,Scott Hoffmann ,Daniel Sutton ,Larissa Carnevalli ,Fernando J Calero-Nieto ,Gemma N Jones ,Andrew J Pierce ,Zena Wilson ,David Campbell ,Lynet Nyoni ,Carla P Martins ,Tamara Baker ,Gilberto Serrano de Almeida ,Zainab Ramlaoui ,Abdel Bidar ,Benjamin Phillips ,Joseph Boland ,Sonia Iyer ,J Carl Barrett ,Arsene-Bienvenu Loembé ,Serge Y Fuchs ,Umamaheswar Duvvuri ,Pei-Jen Lou ,Melonie A Nance ,Carlos Alberto Gomez Roca ,Elaine Cadogan ,Susan E Critichlow ,Steven Fawell ,Mark Cobbold ,Emma Dean ,Viia Valge-Archer ,Alan Lau ,Dmitry I Gabrilovich ,Simon T Barry

Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers

AZD6422(一种靶向CLDN18.2的嵌合抗原受体T细胞)在胃癌、胰腺癌和食管癌中的临床前评估

Allison M Barrett ,Zachary T Britton ,Rosa A Carrasco ,Shannon Breen ,Maria A S Broggi ,Amanda L Hatke ,Benjamin Clark ,Chunning Yang ,Sandrina Phipps ,Lorenzo Ortiz ,Brianna Janocha ,Peter Zanvit ,Nicolas A Giraldo ,Philip L Martin ,Jean-Martin Lapointe ,Nathalie Harder ,Georgina H Cornish ,Bala N N R Attili ,Yariv Mazor ,Melissa Damschroder ,Mark Cobbold ,Gordon Moody ,Emily E Bosco

Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer

AZD0754(一种经dnTGFβRII修饰、靶向STEAP2的CAR-T细胞疗法)在前列腺癌中的抗肿瘤活性

Peter Zanvit ,Dewald van Dyk ,Christine Fazenbaker ,Kelly McGlinchey ,Weichuan Luo ,Jessica M Pezold ,John Meekin ,Chien-Ying Chang ,Rosa A Carrasco ,Shannon Breen ,Crystal Sao-Fong Cheung ,Ariel Endlich-Frazier ,Benjamin Clark ,Nina J Chu ,Alessio Vantellini ,Philip L Martin ,Clare E Hoover ,Kenesha Riley ,Steve M Sweet ,David Chain ,Yeoun Jin Kim ,Eric Tu ,Nathalie Harder ,Sandrina Phipps ,Melissa Damschroder ,Ryan N Gilbreth ,Mark Cobbold ,Gordon Moody ,Emily E Bosco

Single-cell imaging of T cell immunotherapy responses in vivo

体内 T 细胞免疫治疗反应的单细胞成像

Chuan Yan, Qiqi Yang, Songfa Zhang, David G Millar, Eric J Alpert, Daniel Do, Alexandra Veloso, Dalton C Brunson, Benjamin J Drapkin, Marcello Stanzione, Irene Scarfò, John C Moore, Sowmya Iyer, Qian Qin, Yun Wei, Karin M McCarthy, John F Rawls, Nick J Dyson, Mark Cobbold, Marcela V Maus, David M La

Massively parallel interrogation and mining of natively paired human TCRαβ repertoires

大规模并行询问和挖掘天然配对的人类 TCRαβ 库

Matthew J Spindler, Ayla L Nelson, Ellen K Wagner, Natasha Oppermans, John S Bridgeman, James M Heather, Adam S Adler, Michael A Asensio, Robert C Edgar, Yoong Wearn Lim, Everett H Meyer, Robert E Hawkins, Mark Cobbold, David S Johnson

Aberrant X chromosome skewing and acquired clonal hematopoiesis in adult-onset common variable immunodeficiency

成人发病型普通变异型免疫缺陷病中的异常X染色体偏斜和获得性克隆性造血

Gabriel K Wong ,Sara Barmettler ,James M Heather ,David Millar ,Sarah A Penny ,Aarnoud Huissoon ,Alex Richter ,Mark Cobbold

Murine xenograft bioreactors for human immunopeptidome discovery

用于人类免疫肽组发现的鼠异种移植生物反应器

James M Heather, Paisley T Myers, Feng Shi, Mohammad Ovais Aziz-Zanjani, Keira E Mahoney, Matthew Perez, Benjamin Morin, Christine Brittsan, Jeffrey Shabanowitz, Donald F Hunt, Mark Cobbold

The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status

人类 I 类 MHC 磷酸肽的抗原身份主要取决于磷酸化状态

Fiyaz Mohammed #, Daniel H Stones #, Angela L Zarling, Carrie R Willcox, Jeffrey Shabanowitz, Kara L Cummings, Donald F Hunt, Mark Cobbold, Victor H Engelhard, Benjamin E Willcox

Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency

常见变异性免疫缺陷症中 TCR 组多样性加速丧失

Gabriel K Wong, David Millar, Sarah Penny, James M Heather, Punam Mistry, Nico Buettner, Jane Bryon, Aarnoud P Huissoon, Mark Cobbold