日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects

Acasunlimab 是一种 Fc 惰性 PD-L1×4-1BB 双特异性抗体,与 PD-1 阻断剂联合使用可通过互补的免疫调节作用增强抗肿瘤免疫力。

Michela Capello # ,Angelica Sette # ,Theo Plantinga ,Craig J Thalhauser ,Vanessa M Spires ,Kristina B Nürmberger ,Jordan M Blum ,Brandon W Higgs ,Patricia Garrido Castro ,Christina Yu ,Carol Costa Sa ,Sina Fellermeier-Kopf ,Saskia M Burm ,Kristin Strumane ,Aras Toker ,Andrea Imle ,Bruna de Andrade Pereira ,Alexander Muik ,Tahamtan Ahmadi ,Özlem Türeci ,Mark Fereshteh ,Ugur Sahin ,Maria Jure-Kunkel ,Nora Pencheva

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

针对晚期难治性实体瘤患者的靶向PD-L1和4-1BB的双特异性抗体(GEN1046)的临床前特征和I期试验结果

Alexander Muik,Elena Garralda,Isil Altintas,Friederike Gieseke,Ravit Geva,Eytan Ben-Ami,Corinne Maurice-Dror,Emiliano Calvo,Patricia M LoRusso,Guzman Alonso,Maria E Rodriguez-Ruiz,Kristina B Schoedel,Jordan M Blum,Bianca Sänger,Theodora W Salcedo,Saskia M Burm,Eliana Stanganello,Dennis Verzijl,Fulvia Vascotto,Angelica Sette,Juliane Quinkhardt,Theo S Plantinga,Aras Toker,Edward N van den Brink,Mark Fereshteh,Mustafa Diken,David Satijn,Sebastian Kreiter,Esther C W Breij,Gaurav Bajaj,Eleni Lagkadinou,Kate Sasser,Özlem Türeci,Ulf Forssmann,Tahamtan Ahmadi,Uğur Şahin #,Maria Jure-Kunkel #,Ignacio Melero #

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

DuoBody-CD40x4-1BB 通过条件性 CD40 和 4-1BB 激动剂活性诱导树突状细胞成熟并增强 T 细胞活化。

Alexander Muik ,Homer C Adams 3rd ,Friederike Gieseke ,Isil Altintas ,Kristina B Schoedel ,Jordan M Blum ,Bianca Sänger ,Saskia M Burm ,Eliana Stanganello ,Dennis Verzijl ,Vanessa M Spires ,Fulvia Vascotto ,Aras Toker ,Juliane Quinkhardt ,Mark Fereshteh ,Mustafa Diken ,David P E Satijn ,Sebastian Kreiter ,Tahamtan Ahmadi ,Esther C W Breij ,Özlem Türeci ,Kate Sasser ,Ugur Sahin ,Maria Jure-Kunkel