日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Retromer-dependent lysosomal stress in Parkinson's disease

帕金森病中逆转录酶依赖性溶酶体应激

Alessi, Dario R; Cullen, Peter J; Cookson, Mark; Merchant, Kalpana M; Small, Scott A

CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

CD8+ T 细胞内在的 IL-6 信号传导促进对 PD-L1 抗免疫疗法的耐药性

Mahrukh A Huseni ,Lifen Wang ,Joanna E Klementowicz ,Kobe Yuen ,Beatrice Breart ,Christine Orr ,Li-Fen Liu ,Yijin Li ,Vinita Gupta ,Congfen Li ,Deepali Rishipathak ,Jing Peng ,Yasin Şenbabaoǧlu ,Zora Modrusan ,Shilpa Keerthivasan ,Shravan Madireddi ,Ying-Jiun Chen ,Eleanor J Fraser ,Ning Leng ,Habib Hamidi ,Hartmut Koeppen ,James Ziai ,Kenji Hashimoto ,Marcella Fassò ,Patrick Williams ,David F McDermott ,Jonathan E Rosenberg ,Thomas Powles ,Leisha A Emens ,Priti S Hegde ,Ira Mellman ,Shannon J Turley ,Mark S Wilson ,Sanjeev Mariathasan ,Luciana Molinero ,Mark Merchant ,Nathaniel R West

Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors

用于发现和表征 KRAS 抑制剂的构象锁定抗体

Christopher W Davies #, Angela J Oh #, Rana Mroue #, Micah Steffek #, John M Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G Quinn, Sushant Malhot

RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

RTK依赖性诱导突变PI3Kα降解驱动GDC-0077(Inavolisib)疗效

Kyung W Song,Kyle A Edgar,Emily J Hanan,Marc Hafner,Jason Oeh,Mark Merchant,Deepak Sampath,Michelle A Nannini,Rebecca Hong,Lilian Phu,William F Forrest,Eric Stawiski,Stephen Schmidt,Nicholas Endres,Jane Guan,Jeffrey J Wallin,Jonathan Cheong,Emile G Plise,Gail D Lewis Phillips,Laurent Salphati,Timothy P Heffron,Alan G Olivero,Shiva Malek,Steven T Staben,Donald S Kirkpatrick,Anwesha Dey,Lori S Friedman

The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

佛罗里达胰腺癌协作组下一代生物样本库:旨在减少差异并提高不同胰腺癌患者群体生存率的基础设施

Permuth, Jennifer B; Dezsi, Kaleena B; Vyas, Shraddha; Ali, Karla N; Basinski, Toni L; Utuama, Ovie A; Denbo, Jason W; Klapman, Jason; Dam, Aamir; Carballido, Estrella; Kim, Dae Won; Pimiento, Jose M; Powers, Benjamin D; Otto, Amy K; Choi, Jung W; Chen, Dung-Tsa; Teer, Jamie K; Beato, Francisca; Ward, Alina; Cortizas, Elena M; Whisner, Suzanne Y; Williams, Iverson E; Riner, Andrea N; Tardif, Kenneth; Velanovich, Vic; Karachristos, Andreas; Douglas, Wade G; Legaspi, Adrian; Allan, Bassan J; Meredith, Kenneth; Molina-Vega, Manual A; Bao, Philip; St Julien, Jamii; Huguet, Kevin L; Green, Lee; Odedina, Folakemi T; Kumar, Nagi B; Simmons, Vani N; George, Thomas J; Vadaparampil, Susan T; Hodul, Pamela J; Arnoletti, J Pablo; Awad, Ziad T; Bose, Debashish; Jiang, Kun; Centeno, Barbara A; Gwede, Clement K; Malafa, Mokenge; Judge, Sarah M; Judge, Andrew R; Jeong, Daniel; Bloomston, Mark; Merchant, Nipun B; Fleming, Jason B; Trevino, Jose G; On Behalf Of The Florida Pancreas Collaborative

ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer

ERBB3 和 IGF1R 信号传导是 KEAP1 突变肺癌中 Nrf2 依赖性生长所必需的

Steffan Vartanian #, James Lee #, Christiaan Klijn, Florian Gnad, Maria Bagniewska, Gabriele Schaefer, Donglu Zhang, Jenille Tan, Sara A Watson, Liling Liu, Honglin Chen, Yuxin Liang, Colin Watanabe, Trinna Cuellar, David Kan, Ryan J Hartmaier, Ted Lau, Michael R Costa, Scott E Martin, Mark Merchant

Different mechanisms of serum complement activation in the plasma of common (Chelydra serpentina) and alligator (Macrochelys temminckii) snapping turtles

普通鳄龟 (Chelydra serpentina) 和大鳄龟 (Macrochelys temminckii) 血浆中血清补体激活的不同机制

Sarah Baker, Ethan Kessler, Lancia Darville-Bowleg, Mark Merchant

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

通过其激酶结构域破坏 IRE1α 可减轻多发性骨髓瘤

Jonathan M Harnoss, Adrien Le Thomas, Anna Shemorry, Scot A Marsters, David A Lawrence, Min Lu, Yung-Chia Ariel Chen, Jing Qing, Klara Totpal, David Kan, Ehud Segal, Mark Merchant, Mike Reichelt, Heidi Ackerly Wallweber, Weiru Wang, Kevin Clark, Susan Kaufman, Maureen H Beresini, Steven T Laing, Wen

Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

RAS-GTP 的药理诱导使 KRAS 突变肿瘤对 RAF 抑制剂产生敏感性

Ivana Yen, Frances Shanahan, Mark Merchant, Christine Orr, Thomas Hunsaker, Matthew Durk, Hank La, Xiaolin Zhang, Scott E Martin, Eva Lin, John Chan, Yihong Yu, Dhara Amin, Richard M Neve, Amy Gustafson, Avinashnarayan Venkatanarayan, Scott A Foster, Joachim Rudolph, Christiaan Klijn, Shiva Malek

A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

转录 MAPK 通路活性评分 (MPAS) 是多种癌症类型的临床相关生物标志物

Marie-Claire Wagle #, Daniel Kirouac #, Christiaan Klijn, Bonnie Liu, Shilpi Mahajan, Melissa Junttila, John Moffat, Mark Merchant, Ling Huw, Matthew Wongchenko, Kwame Okrah, Shrividhya Srinivasan, Zineb Mounir, Teiko Sumiyoshi, Peter M Haverty, Robert L Yauch, Yibing Yan, Omar Kabbarah, Garret Hamp