日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice

在老年小鼠正常的微生物感染过程中,PD1阻断可提高其存活率和CD8+细胞毒性,且不增加炎症反应。

Korbyn J V Dahlquist,Matthew A Huggins,Matthew J Yousefzadeh,Carolina Soto-Palma,Stephanie H Cholensky,Mark Pierson,Declan M Smith,Sara E Hamilton,Christina D Camell

Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning

Gatad2b 与神经发育综合征 GAND 有关,在神经发育和皮质模式形成中起着关键作用

Clemer Abad, Maria C Robayo, Maria Del Mar Muñiz-Moreno, Maria T Bernardi, Maria G Otero, Christina Kosanovic, Anthony J Griswold, Tyler Mark Pierson, Katherina Walz, Juan I Young

Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening

疾病相关变异的功能效应表明,NMDA 受体的 S1-M1 连接体关键控制着通道的开放

Lingling Xie, Miranda J McDaniel, Riley E Perszyk, Sukhan Kim, Gerarda Cappuccio, Kevin A Shapiro, Beatriz Muñoz-Cabello, Pedro A Sanchez-Lara, Katheryn Grand, Jing Zhang, Kelsey A Nocilla, Rehan Sheikh, Lluis Armengol, Roberta Romano, Tyler Mark Pierson, Hongjie Yuan, Scott J Myers, Stephen F Trayn

A neurodevelopmental disorder associated with an activating de novo missense variant in ARF1

一种与ARF1基因中激活性新生错义变异相关的神经发育障碍

Morié Ishida ,María G Otero ,Christina Freeman ,Pedro A Sánchez-Lara ,Carlos M Guardia ,Tyler Mark Pierson ,Juan S Bonifacino

Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells

经历过微生物感染的“脏”小鼠的 T 细胞启动减少是由于 XCR1+ 树突状细胞产生的 IL-27 有限

Frances V Sjaastad, Matthew A Huggins, Erin D Lucas, Cara Skon-Hegg, Whitney Swanson, Matthew D Martin, Oscar C Salgado, Julie Xu, Mark Pierson, Thamotharampillai Dileepan, Tamara A Kucaba, Sara E Hamilton, Thomas S Griffith

Senolytics reduce coronavirus-related mortality in old mice

衰老细胞因子可降低老年小鼠冠状病毒相关死亡率

Christina D Camell #, Matthew J Yousefzadeh #, Yi Zhu #, Larissa G P Langhi Prata #, Matthew A Huggins, Mark Pierson, Lei Zhang, Ryan D O'Kelly, Tamar Pirtskhalava, Pengcheng Xun, Keisuke Ejima, Ailing Xue, Utkarsh Tripathi, Jair Machado Espindola-Netto, Nino Giorgadze, Elizabeth J Atkinson, Christi

Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia

HPDL基因的双等位基因变异会导致纯粹型和复杂性遗传性痉挛性截瘫。

Manuela Wiessner,Reza Maroofian,Meng-Yuan Ni,Andrea Pedroni,Juliane S Müller,Rolf Stucka,Christian Beetz,Stephanie Efthymiou,Filippo M Santorelli,Ahmed A Alfares,Changlian Zhu,Isabella Ceccherini,Michele Iacomino,Federico Zara,Vincenzo Salpietro,Marcello Scala,Marta Rusmini,Yiran Xu,Yinghong Wang,Yasuhiro Suzuki,Kishin Koh,Haitian Nan,Hiroyuki Ishiura,Shoji Tsuji,Laëtitia Lambert,Emmanuelle Schmitt,Elodie Lacaze,Hanna Küpper,David Dredge,Cara Skraban,Amy Goldstein,Mary J H Willis,Katheryn Grand,John M Graham,Richard A Lewis,Francisca Millan,Özgür Duman,Nihal Dündar,Gökhan Uyanik,Ludger Schöls,Peter Nürnberg,Gudrun Nürnberg,Andrea Catala Bordes,Pavel Seeman,Martin Kuchar,Hossein Darvish,Adriana Rebelo,Filipa Bouçanova,Jean-Jacques Medard,Roman Chrast,Michaela Auer-Grumbach,Fowzan S Alkuraya,Hanan Shamseldin,Saeed Al Tala,Jamileh Rezazadeh Varaghchi,Maryam Najafi,Selina Deschner,Dieter Gläser,Wolfgang Hüttel,Michael C Kruer,Erik-Jan Kamsteeg,Yoshihisa Takiyama,Stephan Züchner,Jonathan Baets,Rebecca Schüle,Rita Horvath,Henry Houlden,Luca Bartesaghi,Hwei-Jen Lee,Konstantinos Ampatzis,Tyler Mark Pierson,Jan Senderek

Generating Mice with Diverse Microbial Experience

培育具有丰富微生物经验的小鼠

Mark Pierson, Anne Merley, Sara E Hamilton

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

UDP-葡萄糖6-脱氢酶功能缺失突变会导致隐性遗传性发育性癫痫性脑病

Holger Hengel # ,Célia Bosso-Lefèvre # ,George Grady ,Emmanuelle Szenker-Ravi ,Hankun Li ,Sarah Pierce ,Élise Lebigot ,Thong-Teck Tan ,Michelle Y Eio ,Gunaseelan Narayanan ,Kagistia Hana Utami ,Monica Yau ,Nader Handal ,Werner Deigendesch ,Reinhard Keimer ,Hiyam M Marzouqa ,Meral Gunay-Aygun ,Michael J Muriello ,Helene Verhelst ,Sarah Weckhuysen ,Sonal Mahida ,Sakkubai Naidu ,Terrence G Thomas ,Jiin Ying Lim ,Ee Shien Tan ,Damien Haye ,Michèl A A P Willemsen ,Renske Oegema ,Wendy G Mitchell ,Tyler Mark Pierson ,Marisa V Andrews ,Marcia C Willing ,Lance H Rodan ,Tahsin Stefan Barakat ,Marjon van Slegtenhorst ,Ralitza H Gavrilova ,Diego Martinelli ,Tal Gilboa ,Abdullah M Tamim ,Mais O Hashem ,Moeenaldeen D AlSayed ,Maha M Abdulrahim ,Mohammed Al-Owain ,Ali Awaji ,Adel A H Mahmoud ,Eissa A Faqeih ,Ali Al Asmari ,Sulwan M Algain ,Lamyaa A Jad ,Hesham M Aldhalaan ,Ingo Helbig ,David A Koolen ,Angelika Riess ,Ingeborg Kraegeloh-Mann ,Peter Bauer ,Suleyman Gulsuner ,Hannah Stamberger ,Alvin Yu Jin Ng ,Sha Tang ,Sumanty Tohari ,Boris Keren ,Laura E Schultz-Rogers ,Eric W Klee ,Sabina Barresi ,Marco Tartaglia ,Hagar Mor-Shaked ,Sateesh Maddirevula ,Amber Begtrup ,Aida Telegrafi ,Rolph Pfundt ,Rebecca Schüle ,Brian Ciruna ,Carine Bonnard ,Mahmoud A Pouladi ,James C Stewart ,Adam Claridge-Chang ,Dirk J Lefeber ,Fowzan S Alkuraya ,Ajay S Mathuru ,Byrappa Venkatesh ,Joseph J Barycki ,Melanie A Simpson ,Saumya S Jamuar ,Ludger Schöls ,Bruno Reversade

Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization

微生物暴露增强了对TLR2识别的病原体的免疫力,但通过TLR4致敏作用增加了对细胞因子风暴的易感性。

Matthew A Huggins ,Frances V Sjaastad ,Mark Pierson ,Tamara A Kucaba ,Whitney Swanson ,Christopher Staley ,Alexa R Weingarden ,Isaac J Jensen ,Derek B Danahy ,Vladimir P Badovinac ,Stephen C Jameson ,Vaiva Vezys ,David Masopust ,Alexander Khoruts ,Thomas S Griffith ,Sara E Hamilton