日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region

HTRA1 的胱氨酸结肽抑制剂与活性位点区域内的隐蔽口袋结合

Yanjie Li #, Yuehua Wei #, Mark Ultsch, Wei Li, Wanjian Tang, Benjamin Tombling, Xinxin Gao, Yoana Dimitrova, Christian Gampe, Jakob Fuhrmann, Yingnan Zhang, Rami N Hannoush, Daniel Kirchhofer

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

通过构象锁机制变构抑制 HTRA1 活性以治疗年龄相关性黄斑变性

Stefan Gerhardy, Mark Ultsch, Wanjian Tang, Evan Green, Jeffrey K Holden, Wei Li, Alberto Estevez, Chris Arthur, Irene Tom, Alexis Rohou, Daniel Kirchhofer

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

ApoL1 和 ApoL2 N 端结构域的结构揭示了非经典的四螺旋束基序

Mark Ultsch, Michael J Holliday, Stefan Gerhardy, Paul Moran, Suzie J Scales, Nidhi Gupta, Francesca Oltrabella, Cecilia Chiu, Wayne Fairbrother, Charles Eigenbrot, Daniel Kirchhofer

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

四价双表位靶向技术能够实现抗体对肿瘤坏死因子受体超家族成员的内在激动作用

Yanli Yang ,Sherry H Yeh ,Shravan Madireddi ,Wadim L Matochko ,Chen Gu ,Patricia Pacheco Sanchez ,Mark Ultsch ,Gladys De Leon Boenig ,Seth F Harris ,Brandon Leonard ,Suzie J Scales ,Jing W Zhu ,Erin Christensen ,Julie Q Hang ,Randall J Brezski ,Scot Marsters ,Avi Ashkenazi ,Siddharth Sukumaran ,Henry Chiu ,Rafael Cubas ,Jeong M Kim ,Greg A Lazar

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

解析TYK2基因座基因型与自身免疫表型之间的差异

Calliope A Dendrou ,Adrian Cortes ,Lydia Shipman ,Hayley G Evans ,Kathrine E Attfield ,Luke Jostins ,Thomas Barber ,Gurman Kaur ,Subita Balaram Kuttikkatte ,Oliver A Leach ,Christiane Desel ,Soren L Faergeman ,Jane Cheeseman ,Matt J Neville ,Stephen Sawcer ,Alastair Compston ,Adam R Johnson ,Christine Everett ,John I Bell ,Fredrik Karpe ,Mark Ultsch ,Charles Eigenbrot ,Gil McVean ,Lars Fugger

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

Crenezumab 与 Aβ 的复合物结构显示 β-发夹结构丢失

Mark Ultsch, Bing Li, Till Maurer, Mary Mathieu, Oskar Adolfsson, Andreas Muhs, Andrea Pfeifer, Maria Pihlgren, Travis W Bainbridge, Mike Reichelt, James A Ernst, Charles Eigenbrot, Germaine Fuh, Jasvinder K Atwal, Ryan J Watts, Weiru Wang

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes

使用文库扫描诱变生成针对神经生长因子的高保真抗体并使用初始和优化的 Fab-抗原复合物的结构进行验证

Sherry L La Porte, Charles Eigenbrot, Mark Ultsch, Wei-Hsien Ho, Davide Foletti, Alison Forgie, Kevin C Lindquist, David L Shelton, Jaume Pons

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

针对人类膜 IgE 片段的特异性抗体会消耗人源化小鼠中产生 IgE 的 B 细胞

Hans D Brightbill, Surinder Jeet, Zhonghua Lin, Donghong Yan, Meijuan Zhou, Martha Tan, Allen Nguyen, Sherry Yeh, Donnie Delarosa, Steven R Leong, Terence Wong, Yvonne Chen, Mark Ultsch, Elizabeth Luis, Sree Ranjani Ramani, Janet Jackman, Lino Gonzalez, Mark S Dennis, Anan Chuntharapai, Laura DeForg