日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

L-Type Ca(v)1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines

L型Ca(v)1.3和HCN通道介导儿茶酚胺引起的心率加快

Torre, Eleonora; Faure, Mélanie; Bidaud, Isabelle; Baudot, Matthias; Gaillardon, Marvin; Pereira de Vasconcelos, Walma; Laarioui, Sihame; Talssi, Leïla; Engeland, Birgit; Reiken, Steven; Saponaro, Andrea; Chen, Bi-Xing; Moroni, Anna; D'Souza, Alicia; Isbrandt, Dirk; Marks, Andrew R; Marx, Steven O; Mesirca, Pietro; Mangoni, Matteo E

Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review

靶向钙调节治疗心力衰竭和心律失常:一项重要综述

Redel-Traub, Gabriel; Marx, Steven O; Marks, Andrew R

Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation

辛伐他汀诱导的骨骼肌无力的结构基础与1型兰尼碱受体T4709M突变相关

Weninger, Gunnar; Dridi, Haikel; Reiken, Steven; Yuan, Qi; Zhao, Nan; Groom, Linda; Leigh, Jennifer; Liu, Yang; Tchagou, Carl; Kang, Jiayi; Chang, Alexander; Luna-Figueroa, Estefania; Miotto, Marco C; Wronska, Anetta; Dirksen, Robert T; Marks, Andrew R

RYR2 Variants in Catecholaminergic Polymorphic Ventricular Tachycardia Patients: Insights From Protein Structure and Clinical Data

RYR2 变异体在儿茶酚胺敏感性多形性室性心动过速患者中的研究:来自蛋白质结构和临床数据的启示

Chang, Alexander; Beqaj, Halil; Sittenfeld, Leah; Miotto, Marco C; Dridi, Haikel; Willson, Gloria; Martinez Jorge, Carolyn; Altosaar Li, Jaan; Reiken, Steven; Liu, Yang; Dai, Zonglin; Tchagou, Carl; Elsayed, Sana; Marx, Steven O; Marks, Andrew R

Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders

利用别嘌醇和黄嘌呤衍生物靶向兰尼碱受体治疗心脏和肌肉骨骼无力疾病

Miotto, Marco C; Luna-Figueroa, Estefania; Tchagou, Carl; Bahlouli, Laith; Reiken, Steven; Dridi, Haikel; Liu, Yang; Weninger, Gunnar; Marks, Andrew R

Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel

针对 RyR1 相关肌病的通用型 Prime 编辑治疗策略:一种保护性突变可挽救 RyR1 通道的渗漏

Godbout, Kelly; Dugas, Mathieu; Reiken, Steven R; Ramezani, Sina; Falle, Alexia; Rousseau, Joël; Wronska, Anetta E; Lamothe, Gabriel; Canet, Geoffrey; Lu, Yaoyao; Planel, Emmanuel; Marks, Andrew R; Tremblay, Jacques P

Rycal S48168 (ARM210) for RYR1-related myopathies: a phase one, open-label, dose-escalation trial

Rycal S48168 (ARM210) 用于治疗 RYR1 相关肌病:一项 I 期、开放标签、剂量递增试验

Todd, Joshua J; Lawal, Tokunbor A; Chrismer, Irene C; Kokkinis, Angela; Grunseich, Christopher; Jain, Minal S; Waite, Melissa R; Biancavilla, Victoria; Pocock, Shavonne; Brooks, Kia; Mendoza, Christopher J; Norato, Gina; Cheung, Ken; Riekhof, Willa; Varma, Pooja; Colina-Prisco, Claudia; Emile-Backer, Magalie; Meilleur, Katherine G; Marks, Andrew R; Webb, Yael; Marcantonio, Eugene E; Foley, A Reghan; Bönnemann, Carsten G; Mohassel, Payam

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

通过结构鉴定,确定 RyR1 的 RY12 结构域为 ADP 传感器,并且是恶性高热疗法药物丹曲林的靶点。

Kim, Kookjoo; Li, Huan; Yuan, Qi; Melville, Zephan; Zalk, Ran; des Georges, Amédée; Frank, Joachim; Hendrickson, Wayne A; Marks, Andrew R; Clarke, Oliver B

Targeting ryanodine receptors to treat human diseases

靶向兰尼碱受体治疗人类疾病

Marks, Andrew R

Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium 'leak' in tremor pathophysiology

小脑兰尼碱受体1型缺陷和内质网钙“泄漏”在震颤病理生理学中的作用

Martuscello, Regina T; Chen, Meng-Ling; Reiken, Steven; Sittenfeld, Leah R; Ruff, David S; Ni, Chun-Lun; Lin, Chih-Chun; Pan, Ming-Kai; Louis, Elan D; Marks, Andrew R; Kuo, Sheng-Han; Faust, Phyllis L